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The map label for this gene is hlyB [H]

Identifier: 66045870

GI number: 66045870

Start: 3199820

End: 3201448

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_2634

Alternate gene names: 66045870

Gene position: 3199820-3201448 (Clockwise)

Preceding gene: 66045858

Following gene: 66045871

Centisome position: 52.51

GC content: 57.83

Gene sequence:

>1629_bases
ATGAACATGATAAATCGCACCAGTTTCGCTAAAAAACTCATGGCCGCGTTCATCGTTTGCGCCATGATCACATTGGCTGT
GGGTGGTTTGGGGATGCTCGGTATCAACCGGCTTTCCGATGCCCTTGAGCTGACATTCTCGAATAACCTGGTTTCAGTGG
CCAACACCAACGAGACGATGACCGCCCTGACCACTCATAACCGCGGGCTTTACCGTTTGCTTGATGCCAAGGATAAGGCC
ACGGCTGAGAAAATGCGCCAAAGCATCAACGGCGAGCTGGAGCGTGCGCAGAAAGTCTATGCCATCTACCGCGCGACTCC
GTTGGAGGACGATGAACGCGCAGCGGGTGACCAGTACGACGCCTTGATGCCGGCCTACATGTCTGCTTCCCAGAACATCT
TTGACCTGCAGCAGGCAGGCAAACTGGAAGACGCGCGCAATCGCCTCAACGCACTGGCGGAAGGAGAGTTCAACAAGGCT
CGCGGCTATCTACAGATCATGATCGACTCCAACAAGCGCCAGATCAAAGAGGGGGCAGAGGCCGCTGACAGGTTGCAAAG
CACCTCGGTATTCATGCTGACCGCGGGTATTGTCATCGCGTTTGTGGTGGCAATCATGTTGGGTATTTTGATCACTCGCA
TGATTACCAGACCACTGAGAAGCGCTATCGAAGTTGCACAACGTATTGCATCGGGTGACCTGACCCAGAGCGTTTCCAGC
ACCCGAGGCGATGAAGCGGGGCACCTGCTGAATGCGATCGGCACGATGCAGGGCAATTTGAAACGAACGATTCAGGAGAT
TTCCAGCGCGTCCGATCAGCTTGCCTCCGCTGCCGAAGAGCTTGGTGCGGTCACTGAAGAAAGCACCCGCGGTCTTACTC
GGCAAAATGACGAGATTCAACAGGCTGCAACGGCAGTGAACGAAATGACAGCGGCTGTTGAAGAGGTAGCCCGCAATGCG
GTGTCTACGTCGGAGGAGTCGAAATCACTGGCAACCGACGCCGCTAACGGGCGGGGCCAGGTGGATAACACCGTCAAGGG
CATAGGCACGATGGTCAGCGAGATTACCGAGTCGACGGGGTCTGTCACTACGCTTGCTGGCCACGTCCGGGATATCAGCA
AAGTGCTCGAGGTCATCCGCAGCATCGCCGAACAGACCAACCTGCTTGCGCTGAACGCCGCCATCGAGGCAGCACGCGCC
GGTGAGCAAGGCAGAGGGTTTGCCGTAGTAGCCGACGAAGTGCGCGCGCTTGCACACCGCACTCAGGCTTCAACGGTGGA
AATCGAAGGCATGATCGGTACCGTGCAGTCCGGCGCCGACGGTGCGGTCGCGGCCATGAGCAAAAGCCTGGCAACGGCCA
CCAACACCCAGGAACTCGCGCAGCGCGCCGGCAGTGCGCTGGAAAAAATCACCAGCGGCGTGGGGATGATCAACGAGCGC
AACATGGTGATTGCCTCGGCGTCCGAAGAGCAGGCCCAGGTCGCACGCGAAGTGGATCGCAACCTGGTCAACATTCAGGA
GCTGAGTGCCCAGTCGGCGGCAGGCGCCAATCAAACGAGCGCATCCAGTCAGGAACTGTCACGGCTGGCGACTTCGTTCA
ACACCATGGTTGCGCAGTTCAAGCTTTAA

Upstream 100 bases:

>100_bases
TTATAGCAGCAGCGCGCAGAACCCTCTTGCTAATGCTCACATGAGCACCGCTGGGCTTGCGGGCAGTTACAGCCATTTAC
TTAACGATGATGGATAATCA

Downstream 100 bases:

>100_bases
CGGGCTTGTGTAGGTGTATTCCCGGTCTGGTCGTCTGGACCATTTGGGCCGGGAATACACGCTGCTTTCCTTTGCTTTTC
TCTTGTTTCAGGGTTGACCT

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MNMINRTSFAKKLMAAFIVCAMITLAVGGLGMLGINRLSDALELTFSNNLVSVANTNETMTALTTHNRGLYRLLDAKDKA
TAEKMRQSINGELERAQKVYAIYRATPLEDDERAAGDQYDALMPAYMSASQNIFDLQQAGKLEDARNRLNALAEGEFNKA
RGYLQIMIDSNKRQIKEGAEAADRLQSTSVFMLTAGIVIAFVVAIMLGILITRMITRPLRSAIEVAQRIASGDLTQSVSS
TRGDEAGHLLNAIGTMQGNLKRTIQEISSASDQLASAAEELGAVTEESTRGLTRQNDEIQQAATAVNEMTAAVEEVARNA
VSTSEESKSLATDAANGRGQVDNTVKGIGTMVSEITESTGSVTTLAGHVRDISKVLEVIRSIAEQTNLLALNAAIEAARA
GEQGRGFAVVADEVRALAHRTQASTVEIEGMIGTVQSGADGAVAAMSKSLATATNTQELAQRAGSALEKITSGVGMINER
NMVIASASEEQAQVAREVDRNLVNIQELSAQSAAGANQTSASSQELSRLATSFNTMVAQFKL

Sequences:

>Translated_542_residues
MNMINRTSFAKKLMAAFIVCAMITLAVGGLGMLGINRLSDALELTFSNNLVSVANTNETMTALTTHNRGLYRLLDAKDKA
TAEKMRQSINGELERAQKVYAIYRATPLEDDERAAGDQYDALMPAYMSASQNIFDLQQAGKLEDARNRLNALAEGEFNKA
RGYLQIMIDSNKRQIKEGAEAADRLQSTSVFMLTAGIVIAFVVAIMLGILITRMITRPLRSAIEVAQRIASGDLTQSVSS
TRGDEAGHLLNAIGTMQGNLKRTIQEISSASDQLASAAEELGAVTEESTRGLTRQNDEIQQAATAVNEMTAAVEEVARNA
VSTSEESKSLATDAANGRGQVDNTVKGIGTMVSEITESTGSVTTLAGHVRDISKVLEVIRSIAEQTNLLALNAAIEAARA
GEQGRGFAVVADEVRALAHRTQASTVEIEGMIGTVQSGADGAVAAMSKSLATATNTQELAQRAGSALEKITSGVGMINER
NMVIASASEEQAQVAREVDRNLVNIQELSAQSAAGANQTSASSQELSRLATSFNTMVAQFKL
>Mature_542_residues
MNMINRTSFAKKLMAAFIVCAMITLAVGGLGMLGINRLSDALELTFSNNLVSVANTNETMTALTTHNRGLYRLLDAKDKA
TAEKMRQSINGELERAQKVYAIYRATPLEDDERAAGDQYDALMPAYMSASQNIFDLQQAGKLEDARNRLNALAEGEFNKA
RGYLQIMIDSNKRQIKEGAEAADRLQSTSVFMLTAGIVIAFVVAIMLGILITRMITRPLRSAIEVAQRIASGDLTQSVSS
TRGDEAGHLLNAIGTMQGNLKRTIQEISSASDQLASAAEELGAVTEESTRGLTRQNDEIQQAATAVNEMTAAVEEVARNA
VSTSEESKSLATDAANGRGQVDNTVKGIGTMVSEITESTGSVTTLAGHVRDISKVLEVIRSIAEQTNLLALNAAIEAARA
GEQGRGFAVVADEVRALAHRTQASTVEIEGMIGTVQSGADGAVAAMSKSLATATNTQELAQRAGSALEKITSGVGMINER
NMVIASASEEQAQVAREVDRNLVNIQELSAQSAAGANQTSASSQELSRLATSFNTMVAQFKL

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=479, Percent_Identity=29.2275574112735, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI2367378, Length=514, Percent_Identity=27.2373540856031, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1788194, Length=489, Percent_Identity=28.8343558282209, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788195, Length=298, Percent_Identity=34.2281879194631, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789453, Length=327, Percent_Identity=32.1100917431193, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57616; Mature: 57616

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMINRTSFAKKLMAAFIVCAMITLAVGGLGMLGINRLSDALELTFSNNLVSVANTNETM
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCEEEEECCCCCE
TALTTHNRGLYRLLDAKDKATAEKMRQSINGELERAQKVYAIYRATPLEDDERAAGDQYD
EEEEECCCCHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHH
ALMPAYMSASQNIFDLQQAGKLEDARNRLNALAEGEFNKARGYLQIMIDSNKRQIKEGAE
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHCCCEEEEEECCCHHHHHHHHH
AADRLQSTSVFMLTAGIVIAFVVAIMLGILITRMITRPLRSAIEVAQRIASGDLTQSVSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TRGDEAGHLLNAIGTMQGNLKRTIQEISSASDQLASAAEELGAVTEESTRGLTRQNDEIQ
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHH
QAATAVNEMTAAVEEVARNAVSTSEESKSLATDAANGRGQVDNTVKGIGTMVSEITESTG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
SVTTLAGHVRDISKVLEVIRSIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHR
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
TQASTVEIEGMIGTVQSGADGAVAAMSKSLATATNTQELAQRAGSALEKITSGVGMINER
HCCCEEEEECHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
NMVIASASEEQAQVAREVDRNLVNIQELSAQSAAGANQTSASSQELSRLATSFNTMVAQF
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KL
CC
>Mature Secondary Structure
MNMINRTSFAKKLMAAFIVCAMITLAVGGLGMLGINRLSDALELTFSNNLVSVANTNETM
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCEEEEECCCCCE
TALTTHNRGLYRLLDAKDKATAEKMRQSINGELERAQKVYAIYRATPLEDDERAAGDQYD
EEEEECCCCHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHH
ALMPAYMSASQNIFDLQQAGKLEDARNRLNALAEGEFNKARGYLQIMIDSNKRQIKEGAE
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHCCCEEEEEECCCHHHHHHHHH
AADRLQSTSVFMLTAGIVIAFVVAIMLGILITRMITRPLRSAIEVAQRIASGDLTQSVSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TRGDEAGHLLNAIGTMQGNLKRTIQEISSASDQLASAAEELGAVTEESTRGLTRQNDEIQ
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHH
QAATAVNEMTAAVEEVARNAVSTSEESKSLATDAANGRGQVDNTVKGIGTMVSEITESTG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
SVTTLAGHVRDISKVLEVIRSIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHR
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHH
TQASTVEIEGMIGTVQSGADGAVAAMSKSLATATNTQELAQRAGSALEKITSGVGMINER
HCCCEEEEECHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
NMVIASASEEQAQVAREVDRNLVNIQELSAQSAAGANQTSASSQELSRLATSFNTMVAQF
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]