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The map label for this gene is mntH1 [H]

Identifier: 66045545

GI number: 66045545

Start: 2680305

End: 2681624

Strand: Direct

Name: mntH1 [H]

Synonym: Psyr_2305

Alternate gene names: 66045545

Gene position: 2680305-2681624 (Clockwise)

Preceding gene: 66045538

Following gene: 66045546

Centisome position: 43.98

GC content: 61.59

Gene sequence:

>1320_bases
GTGACGTACAAACTGCCCACTACTGCCACCGCTCCTTTCTGCCCCTCGGCGACCACGGACAGTGTGGCCATTCCGCCGAA
CGCGTCCTTGCTGCGCAAGATGACGCTGTTTGTCGGGCCTGGCCTGCTGGTTTCCATCGGCTATATGGATCCTGGCAACT
GGGCGACCGCCATCGAGGCCGGGTCGCGCTTCGGCTATTCGCTGCTGTTCGTGGTGGTCCTGGCCAGCCTCTCGGGCATG
GTCTTGCAGAACCTTTGTTCGCGGCTGGGCATCGCGACCGGCCGTGACCTGGCGCAACTGTCCGCCGCACGCTACAGCCG
CAAGGTCGCCAAGGGCCAGTGGTTGCTGGCAGAACTGTCGATCATTGCCACCGATCTGGCGGAAGTGCTGGGCGCTGCGC
TGGCGTTTCATCTGTTGCTCGGCGTTTCCATCACCACCGGTGTGGCGCTGACCGCTTTCGATACGCTGATTGTGCTGGCC
TTGCAGGGCGCCAATTTTCGTCGTCTGGAAGCCATTGTACTGGGGCTGATTGCAACCATCGCCAGTTGCTTTGCCGTCGA
GTTGTTTCTGATCAAGCCATTCTGGCCGGATGTCGTCGCGGGTCTGAAGCCGAGCTGGGATGTGTTGAGCAGCCAGGAGC
CGCTGTACATCGCCATCGGCATTCTGGGCGCCACCGTCATGCCGCATAACCTTTATCTGCATTCGTCTGTGGTGCAGACG
CGGGTCAACGGTTCGGACCAGGCCAGCAAGGCCAGCGCCATTCGCTACGCGCGGCTGGACACCATCGGTTCGCTGAGCCT
GGCGCTGCTGATCAATGCGGCGATTCTGATCCTCGCTGCTGCAGCGTTTCACAAGACCGGGCATACCGAGGTGGTCGAGA
TTCAGGACGCCTATCACCTGCTTGATCCGCTGGTGGGTGGTGCGATCGCCAGCGTGCTGTTCGGTATTGCCTTGCTGGCG
GCGGGGCAGAGCTCGACCTTCACCGGCACCATTGCCGGGCAAGTGGTGCTCGAAGGTTTTCTGCAGGCAAAGATTCCGTG
CTGGCAGCGGCGCTTGATCACCCGTGCACTGGCACTGATTCCGGCGCTGATTGGCGTGATCTGGCTGGGTGACAGCTCGG
TGGGGCAGATGCTGGTGCTCAGTCAGGTCGTACTGAGCCTGCAACTGCCTTTCGCGCTCTGGCCGTTGATTCGTTTTACC
AGCGACCCACAACTGATGGGGCCGTTCGTCAACAGCCGGCTGGTGAAAACGGCGGCCTGGGGGCTGTTCGGACTGATCTC
GGCGGCCAATCTGACGTTACTGTGGTTCTGGATCAGCTGA

Upstream 100 bases:

>100_bases
AGGTACGCGAAAAACAGCAGGCATGAAGCCATCAATGATGTATCAACATGTGTCGCAAAACTTTAGGATTGGGCCTTAAC
TATCTGCATGCCGGGTTCCC

Downstream 100 bases:

>100_bases
ACTTGATCGGCTGCCGCGACTCTCACACCTGACACCAATGTCAGCCGTCAGGTAGCCGGACATGAGCACATCGAGCGACA
AAGGCACCGTCTTCGAAACC

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTYKLPTTATAPFCPSATTDSVAIPPNASLLRKMTLFVGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVVLASLSGM
VLQNLCSRLGIATGRDLAQLSAARYSRKVAKGQWLLAELSIIATDLAEVLGAALAFHLLLGVSITTGVALTAFDTLIVLA
LQGANFRRLEAIVLGLIATIASCFAVELFLIKPFWPDVVAGLKPSWDVLSSQEPLYIAIGILGATVMPHNLYLHSSVVQT
RVNGSDQASKASAIRYARLDTIGSLSLALLINAAILILAAAAFHKTGHTEVVEIQDAYHLLDPLVGGAIASVLFGIALLA
AGQSSTFTGTIAGQVVLEGFLQAKIPCWQRRLITRALALIPALIGVIWLGDSSVGQMLVLSQVVLSLQLPFALWPLIRFT
SDPQLMGPFVNSRLVKTAAWGLFGLISAANLTLLWFWIS

Sequences:

>Translated_439_residues
MTYKLPTTATAPFCPSATTDSVAIPPNASLLRKMTLFVGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVVLASLSGM
VLQNLCSRLGIATGRDLAQLSAARYSRKVAKGQWLLAELSIIATDLAEVLGAALAFHLLLGVSITTGVALTAFDTLIVLA
LQGANFRRLEAIVLGLIATIASCFAVELFLIKPFWPDVVAGLKPSWDVLSSQEPLYIAIGILGATVMPHNLYLHSSVVQT
RVNGSDQASKASAIRYARLDTIGSLSLALLINAAILILAAAAFHKTGHTEVVEIQDAYHLLDPLVGGAIASVLFGIALLA
AGQSSTFTGTIAGQVVLEGFLQAKIPCWQRRLITRALALIPALIGVIWLGDSSVGQMLVLSQVVLSLQLPFALWPLIRFT
SDPQLMGPFVNSRLVKTAAWGLFGLISAANLTLLWFWIS
>Mature_438_residues
TYKLPTTATAPFCPSATTDSVAIPPNASLLRKMTLFVGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVVLASLSGMV
LQNLCSRLGIATGRDLAQLSAARYSRKVAKGQWLLAELSIIATDLAEVLGAALAFHLLLGVSITTGVALTAFDTLIVLAL
QGANFRRLEAIVLGLIATIASCFAVELFLIKPFWPDVVAGLKPSWDVLSSQEPLYIAIGILGATVMPHNLYLHSSVVQTR
VNGSDQASKASAIRYARLDTIGSLSLALLINAAILILAAAAFHKTGHTEVVEIQDAYHLLDPLVGGAIASVLFGIALLAA
GQSSTFTGTIAGQVVLEGFLQAKIPCWQRRLITRALALIPALIGVIWLGDSSVGQMLVLSQVVLSLQLPFALWPLIRFTS
DPQLMGPFVNSRLVKTAAWGLFGLISAANLTLLWFWIS

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=451, Percent_Identity=34.589800443459, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI295293175, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293173, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI10835169, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293178, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293167, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293171, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI295293169, Length=443, Percent_Identity=34.5372460496614, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1788736, Length=405, Percent_Identity=44.1975308641975, Blast_Score=288, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI193210616, Length=445, Percent_Identity=34.3820224719101, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17569473, Length=374, Percent_Identity=35.8288770053476, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71999499, Length=441, Percent_Identity=32.1995464852608, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71993856, Length=230, Percent_Identity=35.2173913043478, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323062, Length=398, Percent_Identity=39.4472361809045, Blast_Score=253, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321841, Length=424, Percent_Identity=39.1509433962264, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324450, Length=422, Percent_Identity=34.5971563981043, Blast_Score=219, Evalue=9e-58,
Organism=Drosophila melanogaster, GI45553443, Length=445, Percent_Identity=34.6067415730337, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24648607, Length=445, Percent_Identity=34.6067415730337, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281362176, Length=445, Percent_Identity=34.6067415730337, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24648609, Length=445, Percent_Identity=34.6067415730337, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46590; Mature: 46458

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYKLPTTATAPFCPSATTDSVAIPPNASLLRKMTLFVGPGLLVSIGYMDPGNWATAIEA
CCEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHC
GSRFGYSLLFVVVLASLSGMVLQNLCSRLGIATGRDLAQLSAARYSRKVAKGQWLLAELS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
IIATDLAEVLGAALAFHLLLGVSITTGVALTAFDTLIVLALQGANFRRLEAIVLGLIATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASCFAVELFLIKPFWPDVVAGLKPSWDVLSSQEPLYIAIGILGATVMPHNLYLHSSVVQT
HHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCCCCEEEEEEHHHHHHCCCCEEEHHHHHHH
RVNGSDQASKASAIRYARLDTIGSLSLALLINAAILILAAAAFHKTGHTEVVEIQDAYHL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHH
LDPLVGGAIASVLFGIALLAAGQSSTFTGTIAGQVVLEGFLQAKIPCWQRRLITRALALI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
PALIGVIWLGDSSVGQMLVLSQVVLSLQLPFALWPLIRFTSDPQLMGPFVNSRLVKTAAW
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHH
GLFGLISAANLTLLWFWIS
HHHHHHHHCCEEEEEEEEC
>Mature Secondary Structure 
TYKLPTTATAPFCPSATTDSVAIPPNASLLRKMTLFVGPGLLVSIGYMDPGNWATAIEA
CEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHC
GSRFGYSLLFVVVLASLSGMVLQNLCSRLGIATGRDLAQLSAARYSRKVAKGQWLLAELS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
IIATDLAEVLGAALAFHLLLGVSITTGVALTAFDTLIVLALQGANFRRLEAIVLGLIATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ASCFAVELFLIKPFWPDVVAGLKPSWDVLSSQEPLYIAIGILGATVMPHNLYLHSSVVQT
HHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCCCCEEEEEEHHHHHHCCCCEEEHHHHHHH
RVNGSDQASKASAIRYARLDTIGSLSLALLINAAILILAAAAFHKTGHTEVVEIQDAYHL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHH
LDPLVGGAIASVLFGIALLAAGQSSTFTGTIAGQVVLEGFLQAKIPCWQRRLITRALALI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
PALIGVIWLGDSSVGQMLVLSQVVLSLQLPFALWPLIRFTSDPQLMGPFVNSRLVKTAAW
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHH
GLFGLISAANLTLLWFWIS
HHHHHHHHCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10844693; 10984043 [H]