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The map label for this gene is thrS [H]

Identifier: 66045402

GI number: 66045402

Start: 2515735

End: 2517657

Strand: Direct

Name: thrS [H]

Synonym: Psyr_2162

Alternate gene names: 66045402

Gene position: 2515735-2517657 (Clockwise)

Preceding gene: 66045399

Following gene: 66045403

Centisome position: 41.28

GC content: 57.36

Gene sequence:

>1923_bases
ATGCCAACTATTACTCTTCCCGACGGCAGTCAACGTTCATTCGATCAGGCGGTTTCCGTAGCCGATGTCGCGCTTTCAAT
CGGTGCCGGTCTGGCCAAGGCCACCGTCGCCGGCAAGGTCGACGGCAAGCTCGTCGACGCCTGCGACCTGATCGAAAACG
ATGCCAGCCTGCAGATCATCACCCCCAAGGATCAGGAAGGACTGGAAATCATCCGTCACTCCTGCGCGCACCTGGTAGGG
CACGCGGTCAAGCAGTTGTATCCGACTGCAAAAATGGTCATCGGCCCGGTGATCGACGACGGCTTCTATTACGATATCGC
CTACGAGCGCCCGTTCACGCCTGACGATATGGCGGCGATCGAACAGCGCATGCAGCAGTTGATCGAAAAAGATTACGACG
TCATCAAGAAAGTCACGCCGCGCGCTGAAGTGATCGAGGTGTTCACCGCCCGTCACGAAGATTACAAGCTGCGTCTGGTC
GAAGACATGCCGAGCGAGCAGGCCATGGGCCTGTATTACCACGAAGAATACGTCGACATGTGCCGCGGTCCACACGTGCC
GAACACTCGCTTCCTGAAGTCATTCAAGTTGACCAAGCTGTCCGGTGCCTACTGGCGTGGCGACGCCAAGAACGAGCAAT
TGCAGCGCGTCTACGGCACTGCCTGGGCCGACAAGAAACAACTGGCAGCCTACATCCAGCGCATCGAAGAAGCCGAAAAA
CGCGACCATCGCAAGATCGGCAAGCGTCTCGGCCTGTTCCATACCCAGGAAGAAGCGCCGGGCATGGTTTTCTGGCACCC
GCAGGGCTGGACCCTGTATCAGGTGCTTGAGCAGTACATGCGTAAAGTGCAGCGTGAGAATGGCTACCTCGAGATCAAGA
CCCCGCAAGTGGTCGATCGCTCGCTCTGGGAAAAATCCGGGCACTGGGCCAACTACGCCGACAACATGTTCACCACCGAG
TCCGAAAGCCGCGACTACGCGATCAAGCCGATGAACTGCCCTTGCCACGTGCAGGTGTTCAATCAGGGCCTGAAAAGCTA
CCGCGAGCTGCCGATGCGTCTGGCCGAGTTCGGTGCCTGTCACCGTAACGAGCCGTCGGGTGCCTTGCACGGCATCATGC
GCGTGCGTGGCTTCACCCAGGACGATGCGCACATCTTCTGTACCGAAGACCAGATGCAGGCCGAGTCCGCCGCGTTCATC
AAGCTGACGCTGGATGTCTACGCCGATTTCGGTTTCAAGGATATCGAACTCAAATTGTCCACTCGCCCTGAAAAGCGTGT
AGGCTCCGACGAGCTTTGGGACCGTGCCGAATCGGCGCTGGCTTCCGCACTCGACAGCGCTGGTCTGCCTTACGACCTGC
AGCCGGGCGAGGGCGCGTTCTACGGTCCGAAAATCGAGTTCTCCCTCAAGGATTGTCTCGGTCGGGTATGGCAGTGCGGC
ACCTTGCAGCTGGACTTCAATCTGCCGATCCGCTTGAGTGCCGAGTACGTTTCGGAAGACAACAGTCGCAAGAATCCGGT
CATGTTGCACCGCGCAATCCTTGGGTCTTTCGAGCGTTTCATCGGAATTCTGATCGAGCATTACGAAGGGGCGTTTCCGG
CCTGGCTGGCGCCTACCCAGGCAGTGATCATGAATATCACTGACAAACAGGCCGATTTTGCCCTCGAAGTGGAAAAAACT
CTGGCCGAAAGCGGGTTTCGTGCCAAGTCCGACTTGAGAAATGAAAAGATCGGCTTTAAAATCCGTGAGCATACTTTGCT
CAAGGTTCCTTATCTCCTCGTGATTGGAGATCGGGAGGTTGAAATGCAAACTGTCGCTGTGCGTACACGTGAAGGCGCTG
ACCTTGGCTCGATGCCGGTCGCCCAATTCGCTGAATTCCTCGCACAAGCGGTTTCCCGGCGTGGTCGCCAAGATACGGAG
TAA

Upstream 100 bases:

>100_bases
GCTCCTGCCACTGTGAGGCAGGCATACCACCGGATCACGTACTGGCTCATCCCAACCCACGTGACCTTTGGTAGGGGTCA
CCACTAGGAGAGGAGGCGCC

Downstream 100 bases:

>100_bases
TTATTATTAAGCGTGAAATGAGACAAGATAAACGAGCTGCACCCAAGGCCCCGATCAATGAAAATATCTCGGCCCGCGAG
GTTCGTTTAATTGGCGCTGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MPTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQIITPKDQEGLEIIRHSCAHLVG
HAVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAIEQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLV
EDMPSEQAMGLYYHEEYVDMCRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEK
RDHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDRSLWEKSGHWANYADNMFTTE
SESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGACHRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFI
KLTLDVYADFGFKDIELKLSTRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCG
TLQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQAVIMNITDKQADFALEVEKT
LAESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREVEMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE

Sequences:

>Translated_640_residues
MPTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQIITPKDQEGLEIIRHSCAHLVG
HAVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAIEQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLV
EDMPSEQAMGLYYHEEYVDMCRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEK
RDHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDRSLWEKSGHWANYADNMFTTE
SESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGACHRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFI
KLTLDVYADFGFKDIELKLSTRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCG
TLQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQAVIMNITDKQADFALEVEKT
LAESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREVEMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE
>Mature_639_residues
PTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQIITPKDQEGLEIIRHSCAHLVGH
AVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAIEQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLVE
DMPSEQAMGLYYHEEYVDMCRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEKR
DHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDRSLWEKSGHWANYADNMFTTES
ESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGACHRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFIK
LTLDVYADFGFKDIELKLSTRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCGT
LQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQAVIMNITDKQADFALEVEKTL
AESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREVEMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=641, Percent_Identity=38.6895475819033, Blast_Score=471, Evalue=1e-132,
Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=39.8671096345515, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI20070344, Length=652, Percent_Identity=36.0429447852761, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI1788013, Length=641, Percent_Identity=65.6786271450858, Blast_Score=907, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=158, Percent_Identity=25.9493670886076, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984184, Length=641, Percent_Identity=39.6255850234009, Blast_Score=478, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71984192, Length=641, Percent_Identity=39.6255850234009, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=40.1273885350318, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=39.7984886649874, Blast_Score=313, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24583842, Length=623, Percent_Identity=39.9678972712681, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI28574141, Length=623, Percent_Identity=39.9678972712681, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24583839, Length=623, Percent_Identity=39.9678972712681, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72613; Mature: 72482

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQII
CCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEE
TPKDQEGLEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCEEEEEEECCCCCCHHHHHH
EQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLVEDMPSEQAMGLYYHEEYVDM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEHHHHHHH
CRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEK
HCCCCCCCHHHHHHHHHEECCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDR
HHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
SLWEKSGHWANYADNMFTTESESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGAC
HHHHCCCCCCCCCCCCEECCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFIKLTLDVYADFGFKDIELKLS
CCCCCCHHHHHHHHHCCCCCCCCEEEEECHHHCCCCEEEEEEEEEEHHCCCCEEEEEEEC
TRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHCCC
TLQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQ
EEEEECCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
AVIMNITDKQADFALEVEKTLAESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREV
EEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCEEEECCEEEEECCCCE
EMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PTITLPDGSQRSFDQAVSVADVALSIGAGLAKATVAGKVDGKLVDACDLIENDASLQII
CEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHCCCCCEEEE
TPKDQEGLEIIRHSCAHLVGHAVKQLYPTAKMVIGPVIDDGFYYDIAYERPFTPDDMAAI
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCEEEEEEECCCCCCHHHHHH
EQRMQQLIEKDYDVIKKVTPRAEVIEVFTARHEDYKLRLVEDMPSEQAMGLYYHEEYVDM
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEHHHHHHH
CRGPHVPNTRFLKSFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEK
HCCCCCCCHHHHHHHHHEECCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKIGKRLGLFHTQEEAPGMVFWHPQGWTLYQVLEQYMRKVQRENGYLEIKTPQVVDR
HHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHH
SLWEKSGHWANYADNMFTTESESRDYAIKPMNCPCHVQVFNQGLKSYRELPMRLAEFGAC
HHHHCCCCCCCCCCCCEECCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HRNEPSGALHGIMRVRGFTQDDAHIFCTEDQMQAESAAFIKLTLDVYADFGFKDIELKLS
CCCCCCHHHHHHHHHCCCCCCCCEEEEECHHHCCCCEEEEEEEEEEHHCCCCEEEEEEEC
TRPEKRVGSDELWDRAESALASALDSAGLPYDLQPGEGAFYGPKIEFSLKDCLGRVWQCG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHCCC
TLQLDFNLPIRLSAEYVSEDNSRKNPVMLHRAILGSFERFIGILIEHYEGAFPAWLAPTQ
EEEEECCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
AVIMNITDKQADFALEVEKTLAESGFRAKSDLRNEKIGFKIREHTLLKVPYLLVIGDREV
EEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCEEEECCEEEEECCCCE
EMQTVAVRTREGADLGSMPVAQFAEFLAQAVSRRGRQDTE
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA