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The map label for this gene is moeA [H]

Identifier: 66045377

GI number: 66045377

Start: 2495721

End: 2496932

Strand: Direct

Name: moeA [H]

Synonym: Psyr_2137

Alternate gene names: 66045377

Gene position: 2495721-2496932 (Clockwise)

Preceding gene: 66045376

Following gene: 66045378

Centisome position: 40.96

GC content: 65.59

Gene sequence:

>1212_bases
ATGAGCCACGAGCCGAAAACCCTGCTGCCTGTTGAAGATGCCATTGCACGGCTGCTGAAGATGGCCGAAGCCACGCCGAT
CACCGAGCGCCAACGCGTCTCGCTGGCCGATGCCGAGGGCCGGGTACTGGCAGTCGATCTGGTCTCCACGCTGGATCTGC
CGCCCTGGCCGAACAGCGCCATGGACGGTTATGCCTTGCGCGCGGCGGACTGGCGCGGCGAGCCGTTGAGCGTCAGTCAG
CGCATCTTCGCCGGTCAGGCCCCCGAGCCTCTGGCCCCTGGCACCTGTGCGCGTATCTTCACCGGCGCGCCGATGCCTGA
AGGCGCTGACTGCGTCGAGATGCAGGAAAACGCCGAGGTGCAGGCGGATCAGCGTGTGCGCTTCAACGAGCCGCTGGGCG
CCGGGCAGAATATTCGTCCGCAAGGCCAGGAAACCCGGGTCGGCGATACCGTGCTGGCCGCCGGCACGCGGCTGGGTCCG
ATCGAACTGGGTCTGGCGGCCTCGCTGGGCCTCGCCGAGCTGGAGGTCATTCGTCGCGTGCGGGTCGCGGTGCTGTCCAC
GGGCGACGAGTTGATTGAGCCCGGTCAGCCATTGGGGCCGGGGCAGATCTACAACAGCAACCGGGTGTTGCTGTGCAGCT
GGTTGAAGCGACTGGAATGCGAGGTCGTGGATGCAGGCATCCTGCCTGATGATCTGGACAAGACTCGCGCTGCACTGGCG
AATCTGCAGGGCGTCGATCTGATTCTCTCCACGGGCGGAGTGTCCGTGGGCGAAGCGGATTTCCTCGGCCACGCATTGCG
TGAAGAGGGCGAACTGACCCTCTGGAAGCTGGCGATCAAGCCTGGCAAGCCGCTGACCTTCGGGCATTTCCGGGGTGTGC
CGGTGATCGGTCTGCCTGGCAATCCGGCCTCTACGCTGGTCACCTTCGCCTTGCTGGCCAGGGCTTACCTGCTGCGTCGC
CAGGGCGTGATCGACGTCGCCCCCTTGCAGTTTCCGGTGCCTGCCGGGTTTGTCTGGACGCGTCCTGGCAATCGCCGCGA
GTACCTGCGCGGCCGTCTGGAGCAGGGGCGGGCCGTGGCTTATCGCAATCAGAGTTCGGGCGTATTGCGCAGCGCTGCAT
GGGCCGATGGTCTGATTGAAGTCCGCGAAGGCTCGACCGTGGCCGAAGGCGACTGGGTCAACTTCATTCCGTTGAGTGAA
GTGCTCGGCTGA

Upstream 100 bases:

>100_bases
CGGCATTCTTGCCCAGCAACTGGATTCGCGCTTCCGGCCTTGCAACTTTGTGCCTCACCTCAAGCAGGCCGAGCCCTGTG
CGACCCGTGGTTGAGTGCTC

Downstream 100 bases:

>100_bases
GTGCATTCGAATGGTGGGGCGGGTACGCATGAGCTACTCTCAACAACGCTGACACAGTGGGCAACCGGACTTCGCCCTGG
AGTATTGTTATGGCGCCATT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSHEPKTLLPVEDAIARLLKMAEATPITERQRVSLADAEGRVLAVDLVSTLDLPPWPNSAMDGYALRAADWRGEPLSVSQ
RIFAGQAPEPLAPGTCARIFTGAPMPEGADCVEMQENAEVQADQRVRFNEPLGAGQNIRPQGQETRVGDTVLAAGTRLGP
IELGLAASLGLAELEVIRRVRVAVLSTGDELIEPGQPLGPGQIYNSNRVLLCSWLKRLECEVVDAGILPDDLDKTRAALA
NLQGVDLILSTGGVSVGEADFLGHALREEGELTLWKLAIKPGKPLTFGHFRGVPVIGLPGNPASTLVTFALLARAYLLRR
QGVIDVAPLQFPVPAGFVWTRPGNRREYLRGRLEQGRAVAYRNQSSGVLRSAAWADGLIEVREGSTVAEGDWVNFIPLSE
VLG

Sequences:

>Translated_403_residues
MSHEPKTLLPVEDAIARLLKMAEATPITERQRVSLADAEGRVLAVDLVSTLDLPPWPNSAMDGYALRAADWRGEPLSVSQ
RIFAGQAPEPLAPGTCARIFTGAPMPEGADCVEMQENAEVQADQRVRFNEPLGAGQNIRPQGQETRVGDTVLAAGTRLGP
IELGLAASLGLAELEVIRRVRVAVLSTGDELIEPGQPLGPGQIYNSNRVLLCSWLKRLECEVVDAGILPDDLDKTRAALA
NLQGVDLILSTGGVSVGEADFLGHALREEGELTLWKLAIKPGKPLTFGHFRGVPVIGLPGNPASTLVTFALLARAYLLRR
QGVIDVAPLQFPVPAGFVWTRPGNRREYLRGRLEQGRAVAYRNQSSGVLRSAAWADGLIEVREGSTVAEGDWVNFIPLSE
VLG
>Mature_402_residues
SHEPKTLLPVEDAIARLLKMAEATPITERQRVSLADAEGRVLAVDLVSTLDLPPWPNSAMDGYALRAADWRGEPLSVSQR
IFAGQAPEPLAPGTCARIFTGAPMPEGADCVEMQENAEVQADQRVRFNEPLGAGQNIRPQGQETRVGDTVLAAGTRLGPI
ELGLAASLGLAELEVIRRVRVAVLSTGDELIEPGQPLGPGQIYNSNRVLLCSWLKRLECEVVDAGILPDDLDKTRAALAN
LQGVDLILSTGGVSVGEADFLGHALREEGELTLWKLAIKPGKPLTFGHFRGVPVIGLPGNPASTLVTFALLARAYLLRRQ
GVIDVAPLQFPVPAGFVWTRPGNRREYLRGRLEQGRAVAYRNQSSGVLRSAAWADGLIEVREGSTVAEGDWVNFIPLSEV
LG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=334, Percent_Identity=36.2275449101796, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI10880983, Length=334, Percent_Identity=36.2275449101796, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1787049, Length=377, Percent_Identity=45.6233421750663, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI25147659, Length=411, Percent_Identity=30.9002433090024, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=406, Percent_Identity=24.1379310344828, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136978, Length=322, Percent_Identity=30.7453416149068, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24638841, Length=322, Percent_Identity=30.7453416149068, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43313; Mature: 43182

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEPKTLLPVEDAIARLLKMAEATPITERQRVSLADAEGRVLAVDLVSTLDLPPWPNSA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCEEEEEEHHHCCCCCCCCCC
MDGYALRAADWRGEPLSVSQRIFAGQAPEPLAPGTCARIFTGAPMPEGADCVEMQENAEV
CCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCCC
QADQRVRFNEPLGAGQNIRPQGQETRVGDTVLAAGTRLGPIELGLAASLGLAELEVIRRV
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECHHHHCCHHHHHHHHHH
RVAVLSTGDELIEPGQPLGPGQIYNSNRVLLCSWLKRLECEVVDAGILPDDLDKTRAALA
HHHHHCCCHHHHCCCCCCCCCEEECCCCEEHHHHHHHHCEEEEECCCCCCHHHHHHHHHH
NLQGVDLILSTGGVSVGEADFLGHALREEGELTLWKLAIKPGKPLTFGHFRGVPVIGLPG
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCCEEEEECCC
NPASTLVTFALLARAYLLRRQGVIDVAPLQFPVPAGFVWTRPGNRREYLRGRLEQGRAVA
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEE
YRNQSSGVLRSAAWADGLIEVREGSTVAEGDWVNFIPLSEVLG
EECCCCCHHHHHHHHCCCEEECCCCEEECCCCEEEEEHHHHCC
>Mature Secondary Structure 
SHEPKTLLPVEDAIARLLKMAEATPITERQRVSLADAEGRVLAVDLVSTLDLPPWPNSA
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCEEEEEEHHHCCCCCCCCCC
MDGYALRAADWRGEPLSVSQRIFAGQAPEPLAPGTCARIFTGAPMPEGADCVEMQENAEV
CCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCCCC
QADQRVRFNEPLGAGQNIRPQGQETRVGDTVLAAGTRLGPIELGLAASLGLAELEVIRRV
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECHHHHCCHHHHHHHHHH
RVAVLSTGDELIEPGQPLGPGQIYNSNRVLLCSWLKRLECEVVDAGILPDDLDKTRAALA
HHHHHCCCHHHHCCCCCCCCCEEECCCCEEHHHHHHHHCEEEEECCCCCCHHHHHHHHHH
NLQGVDLILSTGGVSVGEADFLGHALREEGELTLWKLAIKPGKPLTFGHFRGVPVIGLPG
CCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCCEEEEECCC
NPASTLVTFALLARAYLLRRQGVIDVAPLQFPVPAGFVWTRPGNRREYLRGRLEQGRAVA
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEE
YRNQSSGVLRSAAWADGLIEVREGSTVAEGDWVNFIPLSEVLG
EECCCCCHHHHHHHHCCCEEECCCCEEECCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]