Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 66044567

GI number: 66044567

Start: 1498072

End: 1498719

Strand: Direct

Name: adk [H]

Synonym: Psyr_1319

Alternate gene names: 66044567

Gene position: 1498072-1498719 (Clockwise)

Preceding gene: 66044566

Following gene: 66044568

Centisome position: 24.58

GC content: 59.1

Gene sequence:

>648_bases
ATGCGCGTGATTCTGCTGGGAGCTCCCGGGGCCGGTAAAGGTACTCAGGCAAAATTCATCACTGAAAAGTTCGGCATCCC
GCAGGTTTCGACAGGCGACATGCTGCGCGCTGCAGTCAAGGCTGAAACCGAGCTGGGCCTGAAGGCCAAGAGCGTCATGG
ACTCAGGCGGTCTGGTTTCCGATGACCTGATCATCGGCCTGATCAAGGACCGTCTGGCCGAGCCGGACTGCGCGAACGGC
GTGCTGTTCGATGGCTTCCCGCGCACCATTCCACAGGCCGAAGCCCTGTTGAACGCCGGTCTGGAAATCGACCATGTGCT
GGAAATCGCGGTCGATGACGAAGAAATCGTCAAGCGCATGTCCGGCCGCCGGGTTCACGAAGGTTCCGGGCGCATCTACC
ACACTATCTTCAATCCGCCGAAGGTCGAAGGTATCGATGATGTGACCGGCGAACCGCTGTTGCAGCGCAAGGACGACGTC
GAAGAAACCGTGCGTCATCGCCTGTCCGTGTACCACGCGCAGACCAAGCCGCTGGTCGAGTTTTACAGCAAGCTGGAAGC
GAAGAACGGCAAGCCCAAGTGCAGCCATATCCCGGGCGTCGGCTCGGTTGAGGACATCACTGCAAAAGTACTGAAAGCCT
TGAGCTGA

Upstream 100 bases:

>100_bases
TCTTGATCAGCCTTTCGGCCTATTGGCCTGATTCATTTTTTAGATTGGCCCCCGAGGCGAATCCGATGATTTCACTATAA
AAAATTTGAGGAGCATGACG

Downstream 100 bases:

>100_bases
GGCTCGCAGGCTGAACAATAAATGGCCCGCTTGCGGGCCATTTGTCATTTATACTGCTGCACTTTTTCACATTGACCACG
ACGGAAACACCGATGACCAC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQVSTGDMLRAAVKAETELGLKAKSVMDSGGLVSDDLIIGLIKDRLAEPDCANG
VLFDGFPRTIPQAEALLNAGLEIDHVLEIAVDDEEIVKRMSGRRVHEGSGRIYHTIFNPPKVEGIDDVTGEPLLQRKDDV
EETVRHRLSVYHAQTKPLVEFYSKLEAKNGKPKCSHIPGVGSVEDITAKVLKALS

Sequences:

>Translated_215_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQVSTGDMLRAAVKAETELGLKAKSVMDSGGLVSDDLIIGLIKDRLAEPDCANG
VLFDGFPRTIPQAEALLNAGLEIDHVLEIAVDDEEIVKRMSGRRVHEGSGRIYHTIFNPPKVEGIDDVTGEPLLQRKDDV
EETVRHRLSVYHAQTKPLVEFYSKLEAKNGKPKCSHIPGVGSVEDITAKVLKALS
>Mature_215_residues
MRVILLGAPGAGKGTQAKFITEKFGIPQVSTGDMLRAAVKAETELGLKAKSVMDSGGLVSDDLIIGLIKDRLAEPDCANG
VLFDGFPRTIPQAEALLNAGLEIDHVLEIAVDDEEIVKRMSGRRVHEGSGRIYHTIFNPPKVEGIDDVTGEPLLQRKDDV
EETVRHRLSVYHAQTKPLVEFYSKLEAKNGKPKCSHIPGVGSVEDITAKVLKALS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=189, Percent_Identity=49.7354497354497, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI4502013, Length=189, Percent_Identity=49.7354497354497, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=46.8085106382979, Blast_Score=170, Evalue=9e-43,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=44.5054945054945, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=44.5054945054945, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=44.5054945054945, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=44.5054945054945, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=30.0546448087432, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22749187, Length=190, Percent_Identity=29.4736842105263, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI21450759, Length=138, Percent_Identity=31.8840579710145, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=31.8840579710145, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI28144899, Length=222, Percent_Identity=26.1261261261261, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144897, Length=222, Percent_Identity=26.1261261261261, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7706497, Length=191, Percent_Identity=26.1780104712042, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=62.1495327102804, Blast_Score=270, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17552384, Length=189, Percent_Identity=47.6190476190476, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=205, Percent_Identity=35.609756097561, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=30.5164319248826, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=52.9100529100529, Blast_Score=211, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=192, Percent_Identity=42.7083333333333, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=24.1860465116279, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI22026816, Length=186, Percent_Identity=51.6129032258064, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=42.9347826086957, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=42.9347826086957, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=29.5774647887324, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=29.5774647887324, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23261; Mature: 23261

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILLGAPGAGKGTQAKFITEKFGIPQVSTGDMLRAAVKAETELGLKAKSVMDSGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCC
DDLIIGLIKDRLAEPDCANGVLFDGFPRTIPQAEALLNAGLEIDHVLEIAVDDEEIVKRM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCHHHEEEEEECHHHHHHHH
SGRRVHEGSGRIYHTIFNPPKVEGIDDVTGEPLLQRKDDVEETVRHRLSVYHAQTKPLVE
CCCEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FYSKLEAKNGKPKCSHIPGVGSVEDITAKVLKALS
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRVILLGAPGAGKGTQAKFITEKFGIPQVSTGDMLRAAVKAETELGLKAKSVMDSGGLVS
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCC
DDLIIGLIKDRLAEPDCANGVLFDGFPRTIPQAEALLNAGLEIDHVLEIAVDDEEIVKRM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCHHHEEEEEECHHHHHHHH
SGRRVHEGSGRIYHTIFNPPKVEGIDDVTGEPLLQRKDDVEETVRHRLSVYHAQTKPLVE
CCCEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHH
FYSKLEAKNGKPKCSHIPGVGSVEDITAKVLKALS
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA