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The map label for this gene is hlyB [H]

Identifier: 66043845

GI number: 66043845

Start: 657338

End: 659272

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_0578

Alternate gene names: 66043845

Gene position: 657338-659272 (Clockwise)

Preceding gene: 66043844

Following gene: 66043846

Centisome position: 10.79

GC content: 62.95

Gene sequence:

>1935_bases
GTGTCTGCTGTCTTATCTCTGTTGCAAAGTCGTTTGCTGCGCCCGGTCTTCATCGCGCTGGGCATCGCTCTTTTGGTGCA
GGTCGTGGTGGCGGTTGCGCTTACCCGGAGCACGGTCACCGCGCTTGAGGCTGATCTCGCCAGTCGTCTCGGGGTAGATT
CGCAACATCTTTCCTCAGAGCTGGAGTCGGCGAGTAGCGAAGTGACGTCGAGCCTCGATGCGTTGTCAGCCAGCACTCGT
CAGCGCCTGAGTGTCGGGCTCTCTACCCGTCTGAAGGACGAGCAGGCTCAACTGCGTGCCACGCTGGAGAAAGACCTTCG
CGAGTCCGCGACCGACATGGCTGAACTGCTCGCCGCCGTCGCTCCACGCGCCATGTGGGACAACGACACACCAACGCTTT
CCGAATTCGCACGCCGTGCCCAGCGCAATCCCAATGTACTGTTCGTGGTTTATGACGACGCCGCAGGTGAGCACCTTACG
CGTTACATGAACCGCGACAATCCGCTGGTCAAGGCCTTGCTGGCCAAGGGCGAAGGCGATCGGGCGATGGACAAGGTCCT
CAATGCGGCGAAAAACGATCCTTCCGTGTATTACGTCGAGGCATCCATCAGCCCTAACGGTGTGGAGATCGGCAAGGTGC
GCATGGGTGTATCCACGGCGACGGTCGAAGAGAATCTTGCCGCCCTGGACAAGCGTTTCGCGACCCTGATCACCAGTGGT
GAGCAGTTGGTGTCTGACAGCCTTGCCAGCGCCTCGAAAGACAGTTCGACCGCCTTGCGCACGCGTCTGCAATCCGCTCA
GTCGGCAGCGACTGCAATGACCGGCAATACGCGTGTCGCTGTTCAGGAGGCTGCCGAAACGCTGCGCTGGAGAATCGGCA
CGGGCCTGGCCCTGGTCGGCCTGGGCGTATTGCTGTTACTGGCGGTGGTGCTCGGACGCCGGGTTGTCAGCAAGCTGCAT
CTGCTGATCGCGGCACTCAATGACCTGGCGGCGGGCGAGGGCGATCTGACCAAGCGCGTCAAGCTGGACAGTAACGACGA
GATTGGTGATATGTCGGCCGCGGTCAACCGCTTCATCGACAAGCTGCAACCTATCGTCCGCGAGGCAGGCGAAGTGGCGC
AGCGCACCGGGCAGGAAATCGGTGTCATGAGCGAGCGTAACGCCGGCGCCGATGCGGCGGCCGAATTGCAGCGGGACGAA
GTAGCGGCCAGCCTCAAAGCGCTGGAGCAGATGGCCGACGAGGCGCAGTCGGAAAGCCACGCGATGCAGGCGGCTTTGCG
TCAGGTTATCGACATCAAGCAGGCGACCGACGAAAACACCCGTACGTCCAGTCAGGTTGGCGGGCTGATCGAAGCGCTGG
CCGGGCAGGTCGAGACCGGTGCGCAAGTCATCGAGCGTCTGGCGCAGCAAAGTCAGCAGATCGAGGTGGTGCTGGAAGTC
ATTCATGGTATTGCCGAACAAACCAACCTGCTCGCGTTGAACGCAGCTATCGAAGCGGCCCGTGCAGGGGAGACGGGCAG
GGGCTTTGCCGTGGTGGCTGACGAGGTGCGGGCGCTGGCCAGCAAGACGCAGAGTTCGACGGGTGATATTCAGGCGCACA
TCGTGGCCCTGCAGCGCGGCGCGAAAGAGGCGGTCGCTGCCATCGGCATCGCCGGGCGCCAGGCCAAGGAGGGGCTGGAG
GTATTGCGCGACAGCGCCAAGCGCCAGCAGACGGTGCAGGCCTCGGTGGAGCAGGTGCATGCGGCCATTGGTCTGGCGAC
CAAGGCGGCCGTTCATCAGGCTGAAGGTGCCCAGGCGGTGCGTGGTCGGGTAGAGGTGATCCATGCTCAGGCCGAGCGTG
CTGCGAAGGCTGTGGTGGAGACGACCGCCAGCGGCAAAGTGCTCGATGGACTGGCTGCACAGTTGAAGGCGAGCCTGGGG
CAGTTTCGGGCATGA

Upstream 100 bases:

>100_bases
GCGCACAAAAGTGAGACTTGTGTCACGGCACGGCGCTTGCTACAAAGATGACAGAAAAGTGCCATCATTTTAATGGCGCT
GAGGGTGGAGGGATTCTCCT

Downstream 100 bases:

>100_bases
GCGCCAGGTGCAGCGCTGCAAGTGTGGTGCTGCACTGTCTGCAGGAGGGAGGGCTTTTCGAGTGCCAAACGCAAAAAACC
GAGCCATTGGCTCGGTTTTT

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MSAVLSLLQSRLLRPVFIALGIALLVQVVVAVALTRSTVTALEADLASRLGVDSQHLSSELESASSEVTSSLDALSASTR
QRLSVGLSTRLKDEQAQLRATLEKDLRESATDMAELLAAVAPRAMWDNDTPTLSEFARRAQRNPNVLFVVYDDAAGEHLT
RYMNRDNPLVKALLAKGEGDRAMDKVLNAAKNDPSVYYVEASISPNGVEIGKVRMGVSTATVEENLAALDKRFATLITSG
EQLVSDSLASASKDSSTALRTRLQSAQSAATAMTGNTRVAVQEAAETLRWRIGTGLALVGLGVLLLLAVVLGRRVVSKLH
LLIAALNDLAAGEGDLTKRVKLDSNDEIGDMSAAVNRFIDKLQPIVREAGEVAQRTGQEIGVMSERNAGADAAAELQRDE
VAASLKALEQMADEAQSESHAMQAALRQVIDIKQATDENTRTSSQVGGLIEALAGQVETGAQVIERLAQQSQQIEVVLEV
IHGIAEQTNLLALNAAIEAARAGETGRGFAVVADEVRALASKTQSSTGDIQAHIVALQRGAKEAVAAIGIAGRQAKEGLE
VLRDSAKRQQTVQASVEQVHAAIGLATKAAVHQAEGAQAVRGRVEVIHAQAERAAKAVVETTASGKVLDGLAAQLKASLG
QFRA

Sequences:

>Translated_644_residues
MSAVLSLLQSRLLRPVFIALGIALLVQVVVAVALTRSTVTALEADLASRLGVDSQHLSSELESASSEVTSSLDALSASTR
QRLSVGLSTRLKDEQAQLRATLEKDLRESATDMAELLAAVAPRAMWDNDTPTLSEFARRAQRNPNVLFVVYDDAAGEHLT
RYMNRDNPLVKALLAKGEGDRAMDKVLNAAKNDPSVYYVEASISPNGVEIGKVRMGVSTATVEENLAALDKRFATLITSG
EQLVSDSLASASKDSSTALRTRLQSAQSAATAMTGNTRVAVQEAAETLRWRIGTGLALVGLGVLLLLAVVLGRRVVSKLH
LLIAALNDLAAGEGDLTKRVKLDSNDEIGDMSAAVNRFIDKLQPIVREAGEVAQRTGQEIGVMSERNAGADAAAELQRDE
VAASLKALEQMADEAQSESHAMQAALRQVIDIKQATDENTRTSSQVGGLIEALAGQVETGAQVIERLAQQSQQIEVVLEV
IHGIAEQTNLLALNAAIEAARAGETGRGFAVVADEVRALASKTQSSTGDIQAHIVALQRGAKEAVAAIGIAGRQAKEGLE
VLRDSAKRQQTVQASVEQVHAAIGLATKAAVHQAEGAQAVRGRVEVIHAQAERAAKAVVETTASGKVLDGLAAQLKASLG
QFRA
>Mature_643_residues
SAVLSLLQSRLLRPVFIALGIALLVQVVVAVALTRSTVTALEADLASRLGVDSQHLSSELESASSEVTSSLDALSASTRQ
RLSVGLSTRLKDEQAQLRATLEKDLRESATDMAELLAAVAPRAMWDNDTPTLSEFARRAQRNPNVLFVVYDDAAGEHLTR
YMNRDNPLVKALLAKGEGDRAMDKVLNAAKNDPSVYYVEASISPNGVEIGKVRMGVSTATVEENLAALDKRFATLITSGE
QLVSDSLASASKDSSTALRTRLQSAQSAATAMTGNTRVAVQEAAETLRWRIGTGLALVGLGVLLLLAVVLGRRVVSKLHL
LIAALNDLAAGEGDLTKRVKLDSNDEIGDMSAAVNRFIDKLQPIVREAGEVAQRTGQEIGVMSERNAGADAAAELQRDEV
AASLKALEQMADEAQSESHAMQAALRQVIDIKQATDENTRTSSQVGGLIEALAGQVETGAQVIERLAQQSQQIEVVLEVI
HGIAEQTNLLALNAAIEAARAGETGRGFAVVADEVRALASKTQSSTGDIQAHIVALQRGAKEAVAAIGIAGRQAKEGLEV
LRDSAKRQQTVQASVEQVHAAIGLATKAAVHQAEGAQAVRGRVEVIHAQAERAAKAVVETTASGKVLDGLAAQLKASLGQ
FRA

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=233, Percent_Identity=34.7639484978541, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788194, Length=258, Percent_Identity=31.0077519379845, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI2367378, Length=258, Percent_Identity=32.1705426356589, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787690, Length=267, Percent_Identity=35.5805243445693, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1789453, Length=133, Percent_Identity=41.3533834586466, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 67934; Mature: 67803

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLSLLQSRLLRPVFIALGIALLVQVVVAVALTRSTVTALEADLASRLGVDSQHLSSE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LESASSEVTSSLDALSASTRQRLSVGLSTRLKDEQAQLRATLEKDLRESATDMAELLAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APRAMWDNDTPTLSEFARRAQRNPNVLFVVYDDAAGEHLTRYMNRDNPLVKALLAKGEGD
CCHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCH
RAMDKVLNAAKNDPSVYYVEASISPNGVEIGKVRMGVSTATVEENLAALDKRFATLITSG
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHEEECCHHHHHHHHHHHHHHHHHHHHHCH
EQLVSDSLASASKDSSTALRTRLQSAQSAATAMTGNTRVAVQEAAETLRWRIGTGLALVG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHH
LGVLLLLAVVLGRRVVSKLHLLIAALNDLAAGEGDLTKRVKLDSNDEIGDMSAAVNRFID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KLQPIVREAGEVAQRTGQEIGVMSERNAGADAAAELQRDEVAASLKALEQMADEAQSESH
HHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMQAALRQVIDIKQATDENTRTSSQVGGLIEALAGQVETGAQVIERLAQQSQQIEVVLEV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IHGIAEQTNLLALNAAIEAARAGETGRGFAVVADEVRALASKTQSSTGDIQAHIVALQRG
HHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
AKEAVAAIGIAGRQAKEGLEVLRDSAKRQQTVQASVEQVHAAIGLATKAAVHQAEGAQAV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RGRVEVIHAQAERAAKAVVETTASGKVLDGLAAQLKASLGQFRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAVLSLLQSRLLRPVFIALGIALLVQVVVAVALTRSTVTALEADLASRLGVDSQHLSSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LESASSEVTSSLDALSASTRQRLSVGLSTRLKDEQAQLRATLEKDLRESATDMAELLAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APRAMWDNDTPTLSEFARRAQRNPNVLFVVYDDAAGEHLTRYMNRDNPLVKALLAKGEGD
CCHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHCCCCH
RAMDKVLNAAKNDPSVYYVEASISPNGVEIGKVRMGVSTATVEENLAALDKRFATLITSG
HHHHHHHHHCCCCCCEEEEEECCCCCCCEEEHEEECCHHHHHHHHHHHHHHHHHHHHHCH
EQLVSDSLASASKDSSTALRTRLQSAQSAATAMTGNTRVAVQEAAETLRWRIGTGLALVG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHH
LGVLLLLAVVLGRRVVSKLHLLIAALNDLAAGEGDLTKRVKLDSNDEIGDMSAAVNRFID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KLQPIVREAGEVAQRTGQEIGVMSERNAGADAAAELQRDEVAASLKALEQMADEAQSESH
HHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMQAALRQVIDIKQATDENTRTSSQVGGLIEALAGQVETGAQVIERLAQQSQQIEVVLEV
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IHGIAEQTNLLALNAAIEAARAGETGRGFAVVADEVRALASKTQSSTGDIQAHIVALQRG
HHHHHHHCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
AKEAVAAIGIAGRQAKEGLEVLRDSAKRQQTVQASVEQVHAAIGLATKAAVHQAEGAQAV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RGRVEVIHAQAERAAKAVVETTASGKVLDGLAAQLKASLGQFRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]