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The map label for this gene is hflC [H]

Identifier: 66043842

GI number: 66043842

Start: 653492

End: 654361

Strand: Direct

Name: hflC [H]

Synonym: Psyr_0575

Alternate gene names: 66043842

Gene position: 653492-654361 (Clockwise)

Preceding gene: 66043841

Following gene: 66043843

Centisome position: 10.72

GC content: 58.05

Gene sequence:

>870_bases
ATGAGTAACAAATCACTGATCACCCTTATTGTCGGCGTGGTACTGGCGGTCATTGCCTGGAACAGCTTCTACATAGTGTC
CCAGACCGAACGCGCTGTTCTGCTGCAATTCGGTCGTGTGGTCCAGGCTGACGTTCAGCCGGGTCTGCATGTGAAGGTTC
CTTACGTGAACCAGGTGCGCAAGTTCGACGGTCGTTTGCTGACCCTCGATGCACCGACCCAGCGCTTCCTGACACTGGAA
AAGAAAGCGGTCATGGTCGATGCCTACGCCAAGTGGCGTGTGAAGGATGCGGAGCGTTTCTACACCGCGACTTCCGGCCT
CAAGCAGATCGCCGACGAGCGTCTTTCGCGTCGTCTGGAATCCGGCCTGCGTGACCAGTTCGGTAAGCGCACCCTGCACG
AAGTCGTGTCGGGTGAGCGAGACGCGCTGATGGCGGATATCACCGGTTCGCTGAACCGCATGGCCGAGAAAGAGCTGGGT
ATCGAAGTCGTCGATGTCCGGGTCAAGGCCATCGATCTGCCGAAGGAAGTGAATCGCAGCGTTTTCGAACGTATGAGCAC
CGAGCGTGAGCGTGAAGCGCGCGAGCACCGTGCCAAGGGTAACGAGCTGGCTGAAGGCATCCGTGCCGACGCCGATCGTC
AGCGTCGTGTGCTGCTGGCCGAAGCCTATCGCGAGTCAGAAGAAGCGCGTGGTGATGGTGATGCCCAGGCTGCCGCGATC
TATTCCAAGGCGTATGGTCAGGACCAGGAGTTCTACGCGTTCTATCGCAGCCTGCGTGCCTACCGCGAAAGCTTTGCGAA
CAAGAGCGACGTGATGGTGCTTGATCCGAACAGCGAATTTTTTCGCTACATGGAAAAAGCCAAGCCGTAA

Upstream 100 bases:

>100_bases
GTACGCCATCGCAGTCAGCCAATGATGCTGCCGCTGCTGCCGCCGCCCGGGCGACTGAGGCTCAGCAGCGTGGTGAAGTA
CGTACCAGGGAGACTCGCTG

Downstream 100 bases:

>100_bases
TTAATCATCCGCCGGGCGGCAAAACCGCCCGGTGGGGTGAACGTACGGTGAAACGTGTGTATCATGCGGCAGCCGGGAAA
TTCCCGGCTTTTTTGCGTCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSNKSLITLIVGVVLAVIAWNSFYIVSQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDGRLLTLDAPTQRFLTLE
KKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITGSLNRMAEKELG
IEVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEARGDGDAQAAAI
YSKAYGQDQEFYAFYRSLRAYRESFANKSDVMVLDPNSEFFRYMEKAKP

Sequences:

>Translated_289_residues
MSNKSLITLIVGVVLAVIAWNSFYIVSQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDGRLLTLDAPTQRFLTLE
KKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITGSLNRMAEKELG
IEVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEARGDGDAQAAAI
YSKAYGQDQEFYAFYRSLRAYRESFANKSDVMVLDPNSEFFRYMEKAKP
>Mature_288_residues
SNKSLITLIVGVVLAVIAWNSFYIVSQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVRKFDGRLLTLDAPTQRFLTLEK
KAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLESGLRDQFGKRTLHEVVSGERDALMADITGSLNRMAEKELGI
EVVDVRVKAIDLPKEVNRSVFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEARGDGDAQAAAIY
SKAYGQDQEFYAFYRSLRAYRESFANKSDVMVLDPNSEFFRYMEKAKP

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI21686995, Length=181, Percent_Identity=28.7292817679558, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI221316744, Length=181, Percent_Identity=28.7292817679558, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI38016911, Length=172, Percent_Identity=26.1627906976744, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=38.7820512820513, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1786697, Length=249, Percent_Identity=28.1124497991968, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790616, Length=209, Percent_Identity=28.2296650717703, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569497, Length=198, Percent_Identity=28.2828282828283, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17569499, Length=206, Percent_Identity=29.126213592233, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987612, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25153583, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71989948, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71989955, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71987621, Length=172, Percent_Identity=29.0697674418605, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193209764, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566490, Length=156, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18860517, Length=173, Percent_Identity=29.4797687861272, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24657857, Length=182, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62484448, Length=240, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62484274, Length=240, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281365664, Length=182, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33023; Mature: 32892

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKSLITLIVGVVLAVIAWNSFYIVSQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVR
CCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
KFDGRLLTLDAPTQRFLTLEKKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLE
HHCCEEEEECCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLRDQFGKRTLHEVVSGERDALMADITGSLNRMAEKELGIEVVDVRVKAIDLPKEVNRS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
VFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEARGDGDAQAAAI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSKAYGQDQEFYAFYRSLRAYRESFANKSDVMVLDPNSEFFRYMEKAKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCC
>Mature Secondary Structure 
SNKSLITLIVGVVLAVIAWNSFYIVSQTERAVLLQFGRVVQADVQPGLHVKVPYVNQVR
CCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHH
KFDGRLLTLDAPTQRFLTLEKKAVMVDAYAKWRVKDAERFYTATSGLKQIADERLSRRLE
HHCCEEEEECCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLRDQFGKRTLHEVVSGERDALMADITGSLNRMAEKELGIEVVDVRVKAIDLPKEVNRS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
VFERMSTEREREAREHRAKGNELAEGIRADADRQRRVLLAEAYRESEEARGDGDAQAAAI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YSKAYGQDQEFYAFYRSLRAYRESFANKSDVMVLDPNSEFFRYMEKAKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]