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The map label for this gene is hflK [H]

Identifier: 66043841

GI number: 66043841

Start: 652290

End: 653492

Strand: Direct

Name: hflK [H]

Synonym: Psyr_0574

Alternate gene names: 66043841

Gene position: 652290-653492 (Clockwise)

Preceding gene: 66043840

Following gene: 66043842

Centisome position: 10.7

GC content: 59.93

Gene sequence:

>1203_bases
ATGGCTTGGAATGAGCCGGGTGGCAACTCGAATAATCAAGATCCCTGGGGTGGCAAACGCCGTGGCGGCGACCGCAAGGG
ACCACCTGATCTCGACGAGGCCTTCCGTAAGCTGCAGGAAAGCCTGAAGGGGTTGTTCGGCGGCGGTAACAAACGCGGCA
GCGATGGCGGCAGCAGTGGCAGTGGTGGCGGTTCAGGCAAGGGCGGTGGCTTCGGTCTGCTCGGCATCGGGCTTGTCGTA
CTCGTCGCTTTCTGGCTGTATAGCGCTATCTATGTGGTCGACGAGCAAGAGCAGGCTGTCGTGCTGCGTTTTGGTCAGTA
CCACGAGACCGTGGGCCCGGGCCTTAACATCTACTTCCCGCCGTTCGATCGCAAGTACATGGAGAACGTGACTCGCGAGC
GCGCCTACAGCAAGCAGGGCCAGATGCTCACCGAAGACGAGAACATCGTCGAAGTGCCGCTGACCGTGCAGTACAAGATC
AGCGATCTTCAGGCGTTCGTGCTGAACGTCGATCAGCCTGAAATCAGCCTGCAGCACGCGACTGAAAGTGCGTTGCGTCA
TGTCGTGGGTTCCACGGCGATGGATCAGGTCCTGACTGAAGGCCGCGAACTGATGGCCAGCGAAATCAAGGAGCGTCTGC
AACGCTTCCTCGATACCTACCGCACCGGTATCACCGTGACCCAGGTGAACGTGCAGAGCGCCGCCGCGCCGCGTGAAGTG
CAGGAAGCCTTTGATGACGTGATTCGCGCCCGTGAAGACGAGCAGCGTGCACGTAACCAGGCTGAAAGCTACGCCAATGG
TGTGATCCCGGAAGCCCGTGGTCAGGCTCAGCGTATTCTTGAAGATGCCAACGGTTATCGCGATGAAGTGGTTTCGCGCG
CCAAGGGTGAGGCGGATCGCTTTACCAAACTGGTTGCCGAGTACCGCAAGGCACCTGAAGTCACCCGCCAGCGTCTGTAT
CTGGACACCATGCAGGAAGTCTTCAGCAACACCAGCAAGGTGCTCGTGACCGGCGACAAGGGGCAGAACAACCTGCTTTA
CCTGCCGCTCGACAAGATGATCGAAAGCAGCCGCAGCGGTACCGGCAATGGCTCCAATTCAGGTACGCCATCGCAGTCAG
CCAATGATGCTGCCGCTGCTGCCGCCGCCCGGGCGACTGAGGCTCAGCAGCGTGGTGAAGTACGTACCAGGGAGACTCGC
TGA

Upstream 100 bases:

>100_bases
ATAAAAGCACGAGAAAGCCGTTGTACGGCTTTCCCGAGCATTCTGTAGCATTGGTCGGCGCGCCGCGGGCGCGTCTTTGC
TTTATCAGATGGAGAGCGCT

Downstream 100 bases:

>100_bases
TGAGTAACAAATCACTGATCACCCTTATTGTCGGCGTGGTACTGGCGGTCATTGCCTGGAACAGCTTCTACATAGTGTCC
CAGACCGAACGCGCTGTTCT

Product: HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MAWNEPGGNSNNQDPWGGKRRGGDRKGPPDLDEAFRKLQESLKGLFGGGNKRGSDGGSSGSGGGSGKGGGFGLLGIGLVV
LVAFWLYSAIYVVDEQEQAVVLRFGQYHETVGPGLNIYFPPFDRKYMENVTRERAYSKQGQMLTEDENIVEVPLTVQYKI
SDLQAFVLNVDQPEISLQHATESALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREV
QEAFDDVIRAREDEQRARNQAESYANGVIPEARGQAQRILEDANGYRDEVVSRAKGEADRFTKLVAEYRKAPEVTRQRLY
LDTMQEVFSNTSKVLVTGDKGQNNLLYLPLDKMIESSRSGTGNGSNSGTPSQSANDAAAAAAARATEAQQRGEVRTRETR

Sequences:

>Translated_400_residues
MAWNEPGGNSNNQDPWGGKRRGGDRKGPPDLDEAFRKLQESLKGLFGGGNKRGSDGGSSGSGGGSGKGGGFGLLGIGLVV
LVAFWLYSAIYVVDEQEQAVVLRFGQYHETVGPGLNIYFPPFDRKYMENVTRERAYSKQGQMLTEDENIVEVPLTVQYKI
SDLQAFVLNVDQPEISLQHATESALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREV
QEAFDDVIRAREDEQRARNQAESYANGVIPEARGQAQRILEDANGYRDEVVSRAKGEADRFTKLVAEYRKAPEVTRQRLY
LDTMQEVFSNTSKVLVTGDKGQNNLLYLPLDKMIESSRSGTGNGSNSGTPSQSANDAAAAAAARATEAQQRGEVRTRETR
>Mature_399_residues
AWNEPGGNSNNQDPWGGKRRGGDRKGPPDLDEAFRKLQESLKGLFGGGNKRGSDGGSSGSGGGSGKGGGFGLLGIGLVVL
VAFWLYSAIYVVDEQEQAVVLRFGQYHETVGPGLNIYFPPFDRKYMENVTRERAYSKQGQMLTEDENIVEVPLTVQYKIS
DLQAFVLNVDQPEISLQHATESALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREVQ
EAFDDVIRAREDEQRARNQAESYANGVIPEARGQAQRILEDANGYRDEVVSRAKGEADRFTKLVAEYRKAPEVTRQRLYL
DTMQEVFSNTSKVLVTGDKGQNNLLYLPLDKMIESSRSGTGNGSNSGTPSQSANDAAAAAAARATEAQQRGEVRTRETR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=380, Percent_Identity=42.3684210526316, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786697, Length=256, Percent_Identity=26.5625, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281365664, Length=185, Percent_Identity=27.5675675675676, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484274, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484448, Length=185, Percent_Identity=27.5675675675676, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24657857, Length=185, Percent_Identity=27.5675675675676, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 43876; Mature: 43745

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGGNSNNQDPWGGKRRGGDRKGPPDLDEAFRKLQESLKGLFGGGNKRGSDGGSSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SGGGSGKGGGFGLLGIGLVVLVAFWLYSAIYVVDEQEQAVVLRFGQYHETVGPGLNIYFP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHHCCCCEEEEC
PFDRKYMENVTRERAYSKQGQMLTEDENIVEVPLTVQYKISDLQAFVLNVDQPEISLQHA
CCCHHHHHHHHHHHHHHHCCCEEECCCCEEEECEEEEEEHHHHHHHHEECCCCCHHHHHH
TESALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCHHHH
QEAFDDVIRAREDEQRARNQAESYANGVIPEARGQAQRILEDANGYRDEVVSRAKGEADR
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHH
FTKLVAEYRKAPEVTRQRLYLDTMQEVFSNTSKVLVTGDKGQNNLLYLPLDKMIESSRSG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHCCCC
TGNGSNSGTPSQSANDAAAAAAARATEAQQRGEVRTRETR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AWNEPGGNSNNQDPWGGKRRGGDRKGPPDLDEAFRKLQESLKGLFGGGNKRGSDGGSSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SGGGSGKGGGFGLLGIGLVVLVAFWLYSAIYVVDEQEQAVVLRFGQYHETVGPGLNIYFP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHHCCCCEEEEC
PFDRKYMENVTRERAYSKQGQMLTEDENIVEVPLTVQYKISDLQAFVLNVDQPEISLQHA
CCCHHHHHHHHHHHHHHHCCCEEECCCCEEEECEEEEEEHHHHHHHHEECCCCCHHHHHH
TESALRHVVGSTAMDQVLTEGRELMASEIKERLQRFLDTYRTGITVTQVNVQSAAAPREV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCHHHH
QEAFDDVIRAREDEQRARNQAESYANGVIPEARGQAQRILEDANGYRDEVVSRAKGEADR
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHH
FTKLVAEYRKAPEVTRQRLYLDTMQEVFSNTSKVLVTGDKGQNNLLYLPLDKMIESSRSG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHCCCC
TGNGSNSGTPSQSANDAAAAAAARATEAQQRGEVRTRETR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]