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The map label for this gene is hldE [H]

Identifier: 66043804

GI number: 66043804

Start: 606836

End: 608260

Strand: Direct

Name: hldE [H]

Synonym: Psyr_0537

Alternate gene names: 66043804

Gene position: 606836-608260 (Clockwise)

Preceding gene: 66043803

Following gene: 66043809

Centisome position: 9.96

GC content: 63.23

Gene sequence:

>1425_bases
ATGAAGCTATCCATGCCGCGCTTTGATCAGGCCCCTGTCCTGGTGGTGGGCGATGTCATGCTCGACAGATATTGGCATGG
TGGTACCTCGCGTATTTCCCCTGAAGCGCCAGTGCCTGTGGTCAAGGTCGATCAGATCGAGGACCGTCCGGGTGGCGCTG
CCAACGTGGCCTTGAACATCGCTGCGCTGGGCGCACCGGCTTCGCTGGTCGGTGTGACGGGGGATGACGAAGCTGCCGAG
AGTCTGACCAACAGCCTCAAGGCTGCTGGCGTGCTGGCGCGCTTTCAGCGCATCGCCGATCAGCCGACCATCGTCAAACT
GCGTGTCATGAGTCGCCACCAGCAACTGTTGCGCATCGATTTCGAAGAACCGTTCAGGACCGACCCGCTGGCCCTGAGCG
CAGAGGTCTATAGCTTGCTGGATGGCATCAAGGTGCTGGTCCTGTCGGATTACGGCAAGGGCGCACTGAAAAACCATCAG
GCGCTGATCCAGGCCGCCCGCAAGCGCGGCATTCCGGTGCTGGCCGACCCCAAGGGCAAGGATTTCGCGATTTATCGCGG
TGCCAGCCTGATCACACCGAACCTCAGCGAATTCGAAGCCATCGTCGGCCATTGTGTCGATGAGGCACAACTGGTCACCA
AGGGGGCGCAGTTGATGCAGGAGCTCGATCTCGGCGCGCTGCTGGTGACCCGTGGCGAACATGGCATGACCTTGCTGCGT
CCTGATCAGCAGGCGCTGCACCTGCCGGCCCGTGCCCGCGAAGTGTTCGATGTGACCGGTGCTGGCGATACAGTGATTTC
TACCCTGGCTGCGGCGATCGCTGCCGGTGAGGAACTGCCGCATGCGGTAGCGCTGGCCAATCTGGCCGCGGGCATCGTGG
TCGGCAAGCTGGGCACCGCGGCCATCAGCGCCCCCGAGCTGCGCCGTGCCATTCAGCGCGAAGAGGGCTCCGAACGCGGC
GTGCTGGGGCTGGAGCAACTGCTGCTGGCGGTCGACGATGCGCGCGCGCACAAGGAAAGGATCGTTTTCACCAACGGCTG
TTTCGACATTCTCCACGCCGGTCATGTGACCTATCTGGAGCAGGCGCGCGCCTTGGGCGATCGCCTGATCGTTGCCGTCA
ACGACGATGCGTCCGTCAGCCGCCTGAAAGGGCCGGGCCGACCGATCAACAGCGTCGAACGGCGCATGGCGGTGCTGGCA
GGTCTGGGAGCCGTGGACTGGGTCATCAGCTTCCCGGAAGGAACCCCGGAAAACCTGCTGACTCACGTCAAGCCCGACGT
GCTGGTCAAGGGCGGTGATTACGGTGTCGATCAGGTGGTCGGTGCCGATATCGTTCAGGCGTACGGCGGCGAAGTGCGTG
TGCTGGGGCTGGTGGAAAACAGCTCCACCACCGCGATCGTCGAAAAGATTCGAGGGCAGGGGTAG

Upstream 100 bases:

>100_bases
GTCCGCCTGCCTTTTGAGTGGCGTGATTCAACAGCCTGTCGGTTGCAAACCCCTGTGCTAAGATTCCGCCCCTGTCCATT
TTTCAAGTACGGGTTGTTCC

Downstream 100 bases:

>100_bases
GGGTTAGTTGCAAGCTACAAGCTGCAAGCTACAAGCTACAAGCCACAGCAGATCAAATCAAAAGGCTTGAGGCTTGAGGC
TTGAGGCTTGAGGCTTGAGG

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNIAALGAPASLVGVTGDDEAAE
SLTNSLKAAGVLARFQRIADQPTIVKLRVMSRHQQLLRIDFEEPFRTDPLALSAEVYSLLDGIKVLVLSDYGKGALKNHQ
ALIQAARKRGIPVLADPKGKDFAIYRGASLITPNLSEFEAIVGHCVDEAQLVTKGAQLMQELDLGALLVTRGEHGMTLLR
PDQQALHLPARAREVFDVTGAGDTVISTLAAAIAAGEELPHAVALANLAAGIVVGKLGTAAISAPELRRAIQREEGSERG
VLGLEQLLLAVDDARAHKERIVFTNGCFDILHAGHVTYLEQARALGDRLIVAVNDDASVSRLKGPGRPINSVERRMAVLA
GLGAVDWVISFPEGTPENLLTHVKPDVLVKGGDYGVDQVVGADIVQAYGGEVRVLGLVENSSTTAIVEKIRGQG

Sequences:

>Translated_474_residues
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNIAALGAPASLVGVTGDDEAAE
SLTNSLKAAGVLARFQRIADQPTIVKLRVMSRHQQLLRIDFEEPFRTDPLALSAEVYSLLDGIKVLVLSDYGKGALKNHQ
ALIQAARKRGIPVLADPKGKDFAIYRGASLITPNLSEFEAIVGHCVDEAQLVTKGAQLMQELDLGALLVTRGEHGMTLLR
PDQQALHLPARAREVFDVTGAGDTVISTLAAAIAAGEELPHAVALANLAAGIVVGKLGTAAISAPELRRAIQREEGSERG
VLGLEQLLLAVDDARAHKERIVFTNGCFDILHAGHVTYLEQARALGDRLIVAVNDDASVSRLKGPGRPINSVERRMAVLA
GLGAVDWVISFPEGTPENLLTHVKPDVLVKGGDYGVDQVVGADIVQAYGGEVRVLGLVENSSTTAIVEKIRGQG
>Mature_474_residues
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNIAALGAPASLVGVTGDDEAAE
SLTNSLKAAGVLARFQRIADQPTIVKLRVMSRHQQLLRIDFEEPFRTDPLALSAEVYSLLDGIKVLVLSDYGKGALKNHQ
ALIQAARKRGIPVLADPKGKDFAIYRGASLITPNLSEFEAIVGHCVDEAQLVTKGAQLMQELDLGALLVTRGEHGMTLLR
PDQQALHLPARAREVFDVTGAGDTVISTLAAAIAAGEELPHAVALANLAAGIVVGKLGTAAISAPELRRAIQREEGSERG
VLGLEQLLLAVDDARAHKERIVFTNGCFDILHAGHVTYLEQARALGDRLIVAVNDDASVSRLKGPGRPINSVERRMAVLA
GLGAVDWVISFPEGTPENLLTHVKPDVLVKGGDYGVDQVVGADIVQAYGGEVRVLGLVENSSTTAIVEKIRGQG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=472, Percent_Identity=58.2627118644068, Blast_Score=540, Evalue=1e-155,
Organism=Drosophila melanogaster, GI19921220, Length=94, Percent_Identity=42.5531914893617, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550975, Length=94, Percent_Identity=42.5531914893617, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550973, Length=94, Percent_Identity=42.5531914893617, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550974, Length=94, Percent_Identity=42.5531914893617, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 50314; Mature: 50314

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNI
CCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGAPASLVGVTGDDEAAESLTNSLKAAGVLARFQRIADQPTIVKLRVMSRHQQLLRID
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHEEC
FEEPFRTDPLALSAEVYSLLDGIKVLVLSDYGKGALKNHQALIQAARKRGIPVLADPKGK
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCC
DFAIYRGASLITPNLSEFEAIVGHCVDEAQLVTKGAQLMQELDLGALLVTRGEHGMTLLR
EEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
PDQQALHLPARAREVFDVTGAGDTVISTLAAAIAAGEELPHAVALANLAAGIVVGKLGTA
CCHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHH
AISAPELRRAIQREEGSERGVLGLEQLLLAVDDARAHKERIVFTNGCFDILHAGHVTYLE
HCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHH
QARALGDRLIVAVNDDASVSRLKGPGRPINSVERRMAVLAGLGAVDWVISFPEGTPENLL
HHHHCCCEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCHHHHH
THVKPDVLVKGGDYGVDQVVGADIVQAYGGEVRVLGLVENSSTTAIVEKIRGQG
HHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCC
>Mature Secondary Structure
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNI
CCCCCCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGAPASLVGVTGDDEAAESLTNSLKAAGVLARFQRIADQPTIVKLRVMSRHQQLLRID
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHEEC
FEEPFRTDPLALSAEVYSLLDGIKVLVLSDYGKGALKNHQALIQAARKRGIPVLADPKGK
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCC
DFAIYRGASLITPNLSEFEAIVGHCVDEAQLVTKGAQLMQELDLGALLVTRGEHGMTLLR
EEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
PDQQALHLPARAREVFDVTGAGDTVISTLAAAIAAGEELPHAVALANLAAGIVVGKLGTA
CCHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHH
AISAPELRRAIQREEGSERGVLGLEQLLLAVDDARAHKERIVFTNGCFDILHAGHVTYLE
HCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCHHHHH
QARALGDRLIVAVNDDASVSRLKGPGRPINSVERRMAVLAGLGAVDWVISFPEGTPENLL
HHHHCCCEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHCCCHHHEEEECCCCCHHHHH
THVKPDVLVKGGDYGVDQVVGADIVQAYGGEVRVLGLVENSSTTAIVEKIRGQG
HHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA