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The map label for this gene is aroP

Identifier: 62389997

GI number: 62389997

Start: 1154760

End: 1156151

Strand: Reverse

Name: aroP

Synonym: cg1257

Alternate gene names: 62389997

Gene position: 1156151-1154760 (Counterclockwise)

Preceding gene: 62389998

Following gene: 62389996

Centisome position: 35.22

GC content: 54.02

Gene sequence:

>1392_bases
ATGGCTAAATCTAATGAAGGGCTGGGAACCGGACTTCGGACCCGCCACCTCACAATGATGGGACTCGGCTCCGCAATTGG
TGCCGGACTGTTCCTCGGCACCGGCGTTGGTATCCGCGCAGCCGGCCCCGCAGTGCTCCTGGCGTACATCATCGCCGGAG
CCATCGTTGTGCTTGTTATGCAAATGCTCGGCGAGATGGCTGCTGCCCGTCCCGCCTCCGGATCGTTTTCACGTTACGGC
GAGGATGCTTTCGGCCACTGGGCTGGTTTCTCCCTCGGTTGGTTGTACTGGTTCATGCTGATTATGGTGATGGGCGCCGA
AATGACTGGCGCTGCTGCCATCATGGGTGCATGGTTCGGCGTCGAACCGTGGATTCCTTCGCTTGTCTGCGTGGTCTTCT
TCGCTGTGGTGAACCTCGTCGCGGTTCGCGGTTTCGGTGAATTCGAGTACTGGTTCGCATTCATTAAGGTCGCGGTGATC
ATCGCTTTCCTCATCATTGGTATTGCTCTTATTTTCGGATGGCTTCCCGGATCCACCTTTGTTGGAACCTCAAACTTCAT
CGGTGATCACGGATTCATGCCCAATGGTATTTCTGGTGTTGCTGCTGGTTTGCTCGCGGTGGCTTTTGCCTTTGGTGGCA
TTGAAATTGTCACCATTGCAGCTGCAGAGTCCGATAAGCCACGTGAAGCTATTTCCCTGGCGGTGCGTGCCGTGATTTGG
CGTATTTCAGTCTTTTACTTGGGCTCTGTTTTGGTCATCACTTTCCTCATGCCTTATGAGTCGATCAATGGTGCCGACAC
CGCTGCGGAATCCCCCTTCACCCAAATCCTGGCGATGGCAAACATCCCTGGCACGGTTGGTTTCATGGAAGCGATCATCG
TTCTAGCACTGCTTTCCGCTTTCAACGCCCAAATCTATGCCACTTCTCGTTTGGTATTTTCCATGGCGAATCGACAAGAC
GCTCCGCGAGTTTTCAGTAAGCTCAGCACCAGCCACGTCCCCACCAATGCGGTGCTGTTGTCCATGTTCTTCGCCTTCGT
TTCAGTTGGTTTGCAGTACTGGAATCCAGCCGGTCTGCTTGATTTCCTCCTCAACGCTGTTGGCGGTTGTTTGATTGTGG
TGTGGGCAATGATCACTTTGTCACAGTTGAAACTCCGCAAAGAACTGCAAGCAAACGATGAAATCTCCACGGTTCGCATG
TGGGCGCACCCATGGTTAGGCATCCTCACCTTGGTTTTGTTGGCAGGACTCGTTGCTCTCATGCTCGGCGACGCAGCCTC
CCGCAGCCAGGTTTACTCAGTGGCAATTGTGTACGGATTCTTGGTTCTTTTGTCCTTCGTCACAGTTAACAGCCCATTGC
GCGGAGGTCGCACCCCTTCCGACTTGAACTGA

Upstream 100 bases:

>100_bases
TTGGTCAATCAAGCGTGAATCCGGCTTCCATGAGCCAGTTGCCCGCCTCAAAGCTTGACCCATTTTCATAACCAGTGCCA
TGTGGGTTTACGGTTGATAC

Downstream 100 bases:

>100_bases
TAGGCCGATAGAAATTATTCTGGACGTCATGACTACTGCTTCCGCAACCGGAATTGCAACACTGACCTCCACCGGCGACG
TCCTGGACGTGTGGTATCCA

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAKSNEGLGTGLRTRHLTMMGLGSAIGAGLFLGTGVGIRAAGPAVLLAYIIAGAIVVLVMQMLGEMAAARPASGSFSRYG
EDAFGHWAGFSLGWLYWFMLIMVMGAEMTGAAAIMGAWFGVEPWIPSLVCVVFFAVVNLVAVRGFGEFEYWFAFIKVAVI
IAFLIIGIALIFGWLPGSTFVGTSNFIGDHGFMPNGISGVAAGLLAVAFAFGGIEIVTIAAAESDKPREAISLAVRAVIW
RISVFYLGSVLVITFLMPYESINGADTAAESPFTQILAMANIPGTVGFMEAIIVLALLSAFNAQIYATSRLVFSMANRQD
APRVFSKLSTSHVPTNAVLLSMFFAFVSVGLQYWNPAGLLDFLLNAVGGCLIVVWAMITLSQLKLRKELQANDEISTVRM
WAHPWLGILTLVLLAGLVALMLGDAASRSQVYSVAIVYGFLVLLSFVTVNSPLRGGRTPSDLN

Sequences:

>Translated_463_residues
MAKSNEGLGTGLRTRHLTMMGLGSAIGAGLFLGTGVGIRAAGPAVLLAYIIAGAIVVLVMQMLGEMAAARPASGSFSRYG
EDAFGHWAGFSLGWLYWFMLIMVMGAEMTGAAAIMGAWFGVEPWIPSLVCVVFFAVVNLVAVRGFGEFEYWFAFIKVAVI
IAFLIIGIALIFGWLPGSTFVGTSNFIGDHGFMPNGISGVAAGLLAVAFAFGGIEIVTIAAAESDKPREAISLAVRAVIW
RISVFYLGSVLVITFLMPYESINGADTAAESPFTQILAMANIPGTVGFMEAIIVLALLSAFNAQIYATSRLVFSMANRQD
APRVFSKLSTSHVPTNAVLLSMFFAFVSVGLQYWNPAGLLDFLLNAVGGCLIVVWAMITLSQLKLRKELQANDEISTVRM
WAHPWLGILTLVLLAGLVALMLGDAASRSQVYSVAIVYGFLVLLSFVTVNSPLRGGRTPSDLN
>Mature_462_residues
AKSNEGLGTGLRTRHLTMMGLGSAIGAGLFLGTGVGIRAAGPAVLLAYIIAGAIVVLVMQMLGEMAAARPASGSFSRYGE
DAFGHWAGFSLGWLYWFMLIMVMGAEMTGAAAIMGAWFGVEPWIPSLVCVVFFAVVNLVAVRGFGEFEYWFAFIKVAVII
AFLIIGIALIFGWLPGSTFVGTSNFIGDHGFMPNGISGVAAGLLAVAFAFGGIEIVTIAAAESDKPREAISLAVRAVIWR
ISVFYLGSVLVITFLMPYESINGADTAAESPFTQILAMANIPGTVGFMEAIIVLALLSAFNAQIYATSRLVFSMANRQDA
PRVFSKLSTSHVPTNAVLLSMFFAFVSVGLQYWNPAGLLDFLLNAVGGCLIVVWAMITLSQLKLRKELQANDEISTVRMW
AHPWLGILTLVLLAGLVALMLGDAASRSQVYSVAIVYGFLVLLSFVTVNSPLRGGRTPSDLN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family

Homologues:

Organism=Homo sapiens, GI110347453, Length=304, Percent_Identity=26.6447368421053, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789017, Length=440, Percent_Identity=41.1363636363636, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1786302, Length=439, Percent_Identity=34.1685649202733, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788480, Length=401, Percent_Identity=36.1596009975062, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1786789, Length=443, Percent_Identity=34.3115124153499, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87081708, Length=453, Percent_Identity=35.0993377483444, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI87081915, Length=391, Percent_Identity=34.0153452685422, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786602, Length=393, Percent_Identity=37.4045801526718, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1790653, Length=404, Percent_Identity=31.6831683168317, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI48994972, Length=436, Percent_Identity=33.0275229357798, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082250, Length=342, Percent_Identity=24.5614035087719, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=366, Percent_Identity=25.9562841530055, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324553, Length=427, Percent_Identity=29.03981264637, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=29.6019900497512, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=30.8433734939759, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320772, Length=417, Percent_Identity=29.4964028776978, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=415, Percent_Identity=28.433734939759, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6324990, Length=414, Percent_Identity=28.9855072463768, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=28.287841191067, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324924, Length=465, Percent_Identity=28.1720430107527, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=417, Percent_Identity=27.5779376498801, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324061, Length=413, Percent_Identity=27.1186440677966, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6319542, Length=402, Percent_Identity=26.3681592039801, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=395, Percent_Identity=25.8227848101266, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=437, Percent_Identity=27.9176201372998, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=411, Percent_Identity=24.330900243309, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324981, Length=426, Percent_Identity=31.6901408450704, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324059, Length=413, Percent_Identity=27.3607748184019, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=435, Percent_Identity=25.2873563218391, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=25.4509018036072, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667468, Length=358, Percent_Identity=24.3016759776536, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221512776, Length=354, Percent_Identity=24.8587570621469, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666159, Length=354, Percent_Identity=24.8587570621469, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROP_CORGL (Q46065)

Other databases:

- EMBL:   X85965
- EMBL:   BA000036
- EMBL:   BX927151
- PIR:   S52754
- RefSeq:   NP_600335.2
- RefSeq:   YP_225399.1
- GeneID:   1019092
- GeneID:   3343787
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1257
- KEGG:   cgl:NCgl1062
- HOGENOM:   HBG492579
- OMA:   LSAFNAN
- PhylomeDB:   Q46065
- ProtClustDB:   CLSK638690
- BioCyc:   CGLU196627:CG1257-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 49269; Mature: 49138

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12bf8c58)-; HASH(0x13098198)-; HASH(0x12a8df94)-; HASH(0x12e5bccc)-; HASH(0x12a750dc)-; HASH(0x1162cecc)-; HASH(0xdc75be0)-; HASH(0x40415148)-; HASH(0x121391ac)-; HASH(0x131b7f50)-; HASH(0x131cecec)-; HASH(0x12e9af84)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure 
AKSNEGLGTGLRTRHLTMMGLGSAIGAGLFLGTGVGIRAAGPAVLLAYIIAGAIVVLVM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QMLGEMAAARPASGSFSRYGEDAFGHWAGFSLGWLYWFMLIMVMGAEMTGAAAIMGAWFG
HHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
VEPWIPSLVCVVFFAVVNLVAVRGFGEFEYWFAFIKVAVIIAFLIIGIALIFGWLPGSTF
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGTSNFIGDHGFMPNGISGVAAGLLAVAFAFGGIEIVTIAAAESDKPREAISLAVRAVIW
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RISVFYLGSVLVITFLMPYESINGADTAAESPFTQILAMANIPGTVGFMEAIIVLALLSA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FNAQIYATSRLVFSMANRQDAPRVFSKLSTSHVPTNAVLLSMFFAFVSVGLQYWNPAGLL
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
DFLLNAVGGCLIVVWAMITLSQLKLRKELQANDEISTVRMWAHPWLGILTLVLLAGLVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGDAASRSQVYSVAIVYGFLVLLSFVTVNSPLRGGRTPSDLN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592354; 12948626