Click here to switch to the map view.

The map label for this gene is moeA1 [H]

Identifier: 62389110

GI number: 62389110

Start: 227701

End: 228888

Strand: Reverse

Name: moeA1 [H]

Synonym: cg0261

Alternate gene names: 62389110

Gene position: 228888-227701 (Counterclockwise)

Preceding gene: 62389111

Following gene: 62389109

Centisome position: 6.97

GC content: 56.23

Gene sequence:

>1188_bases
TTGATGTCTCGTTCGCCGGAGCAACATTTGGCAGAAATTTCAGCGCTGCTTCCCCCACAAAAGTCCACGTTCGTGAATCT
GCGCGAAGCGTTGGGACGCCGCACGTTTTCAGCGGTCACTGCGCAGTGGGATTCGCCACGTTTTGATAATTCCCAAATGG
ATGGCTTCGCGCTTGGCCCCTCACATCTTAACGGTGGCACCTTCGCAGTCGGTCCAACCATTCCCGCTGGTCATGATCCT
GATCAGTGGTACCCACGAGGCATCGAAAAAGACATCGCGCCGATTATGACGGGTGCGCGCCTTCCTAAAAACACCGCCGC
GATCATTCCTGTGGAGAAAACCACACCGGGAAATTTCGACGCCCCACAGGTAGAAATCCCCGCCACCCCGCAAGGTCAGT
TCATACGGTTGCAGGGTTCGGATATTACTGCCGGCGACGAGATCATTCCAGCAGGTACGGAGCTTAACTCGGTGCACATC
GGGGTGTTGGCTAGTCAGTCGATCAAGAGCATTGAAGTCGCAGCAAAGCCACGTGTCCTCATCATCACCGGCGGGTCTGA
AATTTCAGAACAGCACGGACCCGCCACGATCCCTGATGCCAACGGCCCTCTGCTTCGTTCCCTGTGCGCCCGCAACAATA
TCGAGGTCATCGCGGGACTGCACACCAACGACGATCCTGAACGACTCCGCTTTGAACTGGAAAACGCCATTGACCAGTAT
CAACCGGATGTCATCATCACCTCTGGTGGTATCAGCCACGGTAAATTTGAGGTGTTTAGGCAGATCCTCGAAGGCACCCC
GAACTCCTGGTTTGGACATGTCGATCAGCAGCCTGGCGGTCCTCAAGGCATCTCCACTTTTGCTGAAACTCCTGTCATTT
CACTTCCCGGAAATCCGATTTCCACCTTGGTGAGTTTCACACTTTTCGTCGCGCCAGCGCTCAACCGCCAGCCGCTCCGC
CACCTCGATGCCCGCATCACCGCTCCGGTCCAGGGCTTGCAAGACAATCGCGAGCAATTCCTTCGCGGCACCATCAGTTA
CCGCAACGGCCACGTCCTCGCCACGCCTCTCCTGGGCACCAGTTCCCACCTGCTGGTTCAAGCTGCCACCGCAGACTGTC
TGATCAGGATCCCGGCGCGGACTACGGTGGAGGAAAACGACATCGTTAAGATTTACCCATTCAACTAA

Upstream 100 bases:

>100_bases
TAAAGCCTTGGGAGCGGTGATTATGCTTTTGGCTGTCTATGTCCTCATCATTGGAGCCATCGGAGCGTTACGATTGTTTT
CCAAGGTGAGAAAGGTTTAA

Downstream 100 bases:

>100_bases
CAGGAGTTAATTTAATGAGCGAGCTCACCCACGTTCGAGCAGACGGTTCCGCACATATGGTGGATGTGACGGGCAAAAAT
GAAACATCGAGAACTGCTGT

Product: molybdopterin CO-factor synthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MMSRSPEQHLAEISALLPPQKSTFVNLREALGRRTFSAVTAQWDSPRFDNSQMDGFALGPSHLNGGTFAVGPTIPAGHDP
DQWYPRGIEKDIAPIMTGARLPKNTAAIIPVEKTTPGNFDAPQVEIPATPQGQFIRLQGSDITAGDEIIPAGTELNSVHI
GVLASQSIKSIEVAAKPRVLIITGGSEISEQHGPATIPDANGPLLRSLCARNNIEVIAGLHTNDDPERLRFELENAIDQY
QPDVIITSGGISHGKFEVFRQILEGTPNSWFGHVDQQPGGPQGISTFAETPVISLPGNPISTLVSFTLFVAPALNRQPLR
HLDARITAPVQGLQDNREQFLRGTISYRNGHVLATPLLGTSSHLLVQAATADCLIRIPARTTVEENDIVKIYPFN

Sequences:

>Translated_395_residues
MMSRSPEQHLAEISALLPPQKSTFVNLREALGRRTFSAVTAQWDSPRFDNSQMDGFALGPSHLNGGTFAVGPTIPAGHDP
DQWYPRGIEKDIAPIMTGARLPKNTAAIIPVEKTTPGNFDAPQVEIPATPQGQFIRLQGSDITAGDEIIPAGTELNSVHI
GVLASQSIKSIEVAAKPRVLIITGGSEISEQHGPATIPDANGPLLRSLCARNNIEVIAGLHTNDDPERLRFELENAIDQY
QPDVIITSGGISHGKFEVFRQILEGTPNSWFGHVDQQPGGPQGISTFAETPVISLPGNPISTLVSFTLFVAPALNRQPLR
HLDARITAPVQGLQDNREQFLRGTISYRNGHVLATPLLGTSSHLLVQAATADCLIRIPARTTVEENDIVKIYPFN
>Mature_395_residues
MMSRSPEQHLAEISALLPPQKSTFVNLREALGRRTFSAVTAQWDSPRFDNSQMDGFALGPSHLNGGTFAVGPTIPAGHDP
DQWYPRGIEKDIAPIMTGARLPKNTAAIIPVEKTTPGNFDAPQVEIPATPQGQFIRLQGSDITAGDEIIPAGTELNSVHI
GVLASQSIKSIEVAAKPRVLIITGGSEISEQHGPATIPDANGPLLRSLCARNNIEVIAGLHTNDDPERLRFELENAIDQY
QPDVIITSGGISHGKFEVFRQILEGTPNSWFGHVDQQPGGPQGISTFAETPVISLPGNPISTLVSFTLFVAPALNRQPLR
HLDARITAPVQGLQDNREQFLRGTISYRNGHVLATPLLGTSSHLLVQAATADCLIRIPARTTVEENDIVKIYPFN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=357, Percent_Identity=28.0112044817927, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI10880983, Length=357, Percent_Identity=28.0112044817927, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1787049, Length=360, Percent_Identity=30.2777777777778, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25147659, Length=399, Percent_Identity=29.0726817042606, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17562606, Length=384, Percent_Identity=24.4791666666667, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136978, Length=355, Percent_Identity=28.4507042253521, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24638841, Length=355, Percent_Identity=28.4507042253521, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42627; Mature: 42627

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSRSPEQHLAEISALLPPQKSTFVNLREALGRRTFSAVTAQWDSPRFDNSQMDGFALGP
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCEEECC
SHLNGGTFAVGPTIPAGHDPDQWYPRGIEKDIAPIMTGARLPKNTAAIIPVEKTTPGNFD
CCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
APQVEIPATPQGQFIRLQGSDITAGDEIIPAGTELNSVHIGVLASQSIKSIEVAAKPRVL
CCEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCCEEEEEEEECCCCCEEEEECCCEEE
IITGGSEISEQHGPATIPDANGPLLRSLCARNNIEVIAGLHTNDDPERLRFELENAIDQY
EEECCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
QPDVIITSGGISHGKFEVFRQILEGTPNSWFGHVDQQPGGPQGISTFAETPVISLPGNPI
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCHH
STLVSFTLFVAPALNRQPLRHLDARITAPVQGLQDNREQFLRGTISYRNGHVLATPLLGT
HHHHHHHHHHHCCCCCCHHHHHHCEECCCHHCHHHHHHHHHHHHEEECCCEEEEEECCCC
SSHLLVQAATADCLIRIPARTTVEENDIVKIYPFN
CCCEEEEEECCCEEEECCCCCEECCCCEEEEEECC
>Mature Secondary Structure
MMSRSPEQHLAEISALLPPQKSTFVNLREALGRRTFSAVTAQWDSPRFDNSQMDGFALGP
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCEEECC
SHLNGGTFAVGPTIPAGHDPDQWYPRGIEKDIAPIMTGARLPKNTAAIIPVEKTTPGNFD
CCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCC
APQVEIPATPQGQFIRLQGSDITAGDEIIPAGTELNSVHIGVLASQSIKSIEVAAKPRVL
CCEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCCEEEEEEEECCCCCEEEEECCCEEE
IITGGSEISEQHGPATIPDANGPLLRSLCARNNIEVIAGLHTNDDPERLRFELENAIDQY
EEECCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
QPDVIITSGGISHGKFEVFRQILEGTPNSWFGHVDQQPGGPQGISTFAETPVISLPGNPI
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECCCCHH
STLVSFTLFVAPALNRQPLRHLDARITAPVQGLQDNREQFLRGTISYRNGHVLATPLLGT
HHHHHHHHHHHCCCCCCHHHHHHCEECCCHHCHHHHHHHHHHHHEEECCCEEEEEECCCC
SSHLLVQAATADCLIRIPARTTVEENDIVKIYPFN
CCCEEEEEECCCEEEECCCCCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]