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The map label for this gene is dprE1 [H]

Identifier: 62389087

GI number: 62389087

Start: 209990

End: 211456

Strand: Reverse

Name: dprE1 [H]

Synonym: cg0238

Alternate gene names: 62389087

Gene position: 211456-209990 (Counterclockwise)

Preceding gene: 62389088

Following gene: 62389086

Centisome position: 6.44

GC content: 57.4

Gene sequence:

>1467_bases
ATGAACAGTTCTCACGGCACGTCCAGCTCCGGCGCTTCGGCCGGTGCCCACGGAGCCCTTCCCCTAGAAGCTCAGAAACT
GAACGGTTGGGGCCGCACAGCCCCCACCACCGCTGAGGTACTTACCACCCCAGACCTAGACATCATTGTGGATGCAGTCC
GCCAAGTCGCTGAACAAAACGACTCCAAGCCGGACTACCTCAAGCGCGGCGTGATTGCCCGTGGCATGGGTCGTTCCTAT
GGTGACCCAGCCCAAAACGCCGGTGGCCTTGTCATTGACATGCAGCCACTGAACAAAATCCACTCGATTGATCCTGATTC
TGCGATCGTCGATGTAGATGGCGGCGTCACCCTCGATCAGCTCATGAAGGCTGCCCTGCCATATGGCCTCTGGGTTCCTG
TCCTTCCCGGCACCCGCCAAGTCACCATCGGTGGCGCAATCGGACCAGACATCCACGGTAAGAACCACCACTCTGCAGGT
TCCTTCGGCGACCACGTGGTCTCCATGGAACTCCTCGTTGCAGACGGACGCATCCTGCACCTCGAGCCAGAAGGCACCGC
CGAAGACCCACAGGGCGACCTGTTCTGGGCAACCGTTGGTGGCATGGGCCTGACCGGCATCATCGTCCGTGCACGCATCC
GCATGACCAAGACGGAAACCGCCTACTTCATTGCGGACACCGACCGCACCAACAACTTGGAAGAAACCGTTGCGTTCCAC
TCCGACGGATCAGAGCACAACTACACCTATTCTTCTGCGTGGTTCGATGTCATCAGCCCTGAGCCAAAGCTTGGCCGCTC
CACCATCTCCCGTGGTTCCCTGGCAACACTTGCTCAGCTGGAAGAATTGGCACCAAAGCTGGCCAAGGATCCACTGAAGT
TTAATGCTCCACAGCTGATGAAGGTTCCAGATATCTTCCCATCCTGGACTTTGAACAAGCTGACCCTTTCCGCAGTCGGT
GTGGCTTACTACGCCATGGGTGCACCAGCGAAAAACCAGGTGAAAAACCTCACCCAGTTCTACCAACCACTGGATTTGAT
CGGCGAATGGAACCGTGGCTACGGCTCCAAGGGCTTCCTGCAGTACCAGTTCGTGGTCCCCACAGAAGCTGTTGAGCCTT
TCAAGGACATCATCCGCGATATGCAAAAGTCCGGCCACTACTCCGCACTCAACGTGTTCAAACTGTTTGGCCCAGGCAAC
CGCGCACCACTGTCCTACCCAATGCCAGGCTGGAACGTCTGCGTTGACTTCCCTATCCGCCCAGGTCTGGGAGCTTTCTT
GGACGATCTGGACAAGCGCGTCATGGAATTCGGCGGCCGCCTCTACCTGGCCAAGGAATCCCGCACCTCCGCAGAGAACT
TCCACGCCATGTACCCAGGTATGGAAGGCTGGTTGAAGACTCGAAATGAGATCGACCCAACCGGAGTCTTTGCATCTGAC
ATGTCCCGCCGACTTGAGCTTTCTTAA

Upstream 100 bases:

>100_bases
ATTCGTGAACTCATGGATCTTTAGGCAATAAATGTGAGATTGGACGATTTCACGCTTGTCTTCACCACCTGAAAATTTTC
GGGGGTAACCTTTAAAGGCG

Downstream 100 bases:

>100_bases
GAAAGGGCTTGAACTAAACAATGCTTAACGCAGTGGGCAAAGCCCAAAACATTCTCCTTCTTGGTGGAACCTCTGAGATC
GGTATTTCCATTGTCTCCCG

Product: L-gulonolactone oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNSSHGTSSSGASAGAHGALPLEAQKLNGWGRTAPTTAEVLTTPDLDIIVDAVRQVAEQNDSKPDYLKRGVIARGMGRSY
GDPAQNAGGLVIDMQPLNKIHSIDPDSAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAG
SFGDHVVSMELLVADGRILHLEPEGTAEDPQGDLFWATVGGMGLTGIIVRARIRMTKTETAYFIADTDRTNNLEETVAFH
SDGSEHNYTYSSAWFDVISPEPKLGRSTISRGSLATLAQLEELAPKLAKDPLKFNAPQLMKVPDIFPSWTLNKLTLSAVG
VAYYAMGAPAKNQVKNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKDIIRDMQKSGHYSALNVFKLFGPGN
RAPLSYPMPGWNVCVDFPIRPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHAMYPGMEGWLKTRNEIDPTGVFASD
MSRRLELS

Sequences:

>Translated_488_residues
MNSSHGTSSSGASAGAHGALPLEAQKLNGWGRTAPTTAEVLTTPDLDIIVDAVRQVAEQNDSKPDYLKRGVIARGMGRSY
GDPAQNAGGLVIDMQPLNKIHSIDPDSAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAG
SFGDHVVSMELLVADGRILHLEPEGTAEDPQGDLFWATVGGMGLTGIIVRARIRMTKTETAYFIADTDRTNNLEETVAFH
SDGSEHNYTYSSAWFDVISPEPKLGRSTISRGSLATLAQLEELAPKLAKDPLKFNAPQLMKVPDIFPSWTLNKLTLSAVG
VAYYAMGAPAKNQVKNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKDIIRDMQKSGHYSALNVFKLFGPGN
RAPLSYPMPGWNVCVDFPIRPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHAMYPGMEGWLKTRNEIDPTGVFASD
MSRRLELS
>Mature_488_residues
MNSSHGTSSSGASAGAHGALPLEAQKLNGWGRTAPTTAEVLTTPDLDIIVDAVRQVAEQNDSKPDYLKRGVIARGMGRSY
GDPAQNAGGLVIDMQPLNKIHSIDPDSAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAG
SFGDHVVSMELLVADGRILHLEPEGTAEDPQGDLFWATVGGMGLTGIIVRARIRMTKTETAYFIADTDRTNNLEETVAFH
SDGSEHNYTYSSAWFDVISPEPKLGRSTISRGSLATLAQLEELAPKLAKDPLKFNAPQLMKVPDIFPSWTLNKLTLSAVG
VAYYAMGAPAKNQVKNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPTEAVEPFKDIIRDMQKSGHYSALNVFKLFGPGN
RAPLSYPMPGWNVCVDFPIRPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHAMYPGMEGWLKTRNEIDPTGVFASD
MSRRLELS

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 53063; Mature: 53063

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSHGTSSSGASAGAHGALPLEAQKLNGWGRTAPTTAEVLTTPDLDIIVDAVRQVAEQN
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
DSKPDYLKRGVIARGMGRSYGDPAQNAGGLVIDMQPLNKIHSIDPDSAIVDVDGGVTLDQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEECCCCCCHHH
LMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVVSMELLVADGRILH
HHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEE
LEPEGTAEDPQGDLFWATVGGMGLTGIIVRARIRMTKTETAYFIADTDRTNNLEETVAFH
ECCCCCCCCCCCCEEEEEECCCCHHHHHEEEEEEEEECCEEEEEEECCCCCCHHHHHEEC
SDGSEHNYTYSSAWFDVISPEPKLGRSTISRGSLATLAQLEELAPKLAKDPLKFNAPQLM
CCCCCCCEEECCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
KVPDIFPSWTLNKLTLSAVGVAYYAMGAPAKNQVKNLTQFYQPLDLIGEWNRGYGSKGFL
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
QYQFVVPTEAVEPFKDIIRDMQKSGHYSALNVFKLFGPGNRAPLSYPMPGWNVCVDFPIR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCC
PGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHAMYPGMEGWLKTRNEIDPTGVFASD
CCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHEECCCCHHHHHHCCCCCCCCCEEHHH
MSRRLELS
HHHHCCCC
>Mature Secondary Structure
MNSSHGTSSSGASAGAHGALPLEAQKLNGWGRTAPTTAEVLTTPDLDIIVDAVRQVAEQN
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCC
DSKPDYLKRGVIARGMGRSYGDPAQNAGGLVIDMQPLNKIHSIDPDSAIVDVDGGVTLDQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCEEEECCCCCCHHH
LMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVVSMELLVADGRILH
HHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEEE
LEPEGTAEDPQGDLFWATVGGMGLTGIIVRARIRMTKTETAYFIADTDRTNNLEETVAFH
ECCCCCCCCCCCCEEEEEECCCCHHHHHEEEEEEEEECCEEEEEEECCCCCCHHHHHEEC
SDGSEHNYTYSSAWFDVISPEPKLGRSTISRGSLATLAQLEELAPKLAKDPLKFNAPQLM
CCCCCCCEEECCEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCE
KVPDIFPSWTLNKLTLSAVGVAYYAMGAPAKNQVKNLTQFYQPLDLIGEWNRGYGSKGFL
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
QYQFVVPTEAVEPFKDIIRDMQKSGHYSALNVFKLFGPGNRAPLSYPMPGWNVCVDFPIR
EEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCC
PGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHAMYPGMEGWLKTRNEIDPTGVFASD
CCHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHEECCCCHHHHHHCCCCCCCCCEEHHH
MSRRLELS
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]