Click here to switch to the map view.

The map label for this gene is panB [H]

Identifier: 62389009

GI number: 62389009

Start: 127190

End: 128005

Strand: Reverse

Name: panB [H]

Synonym: cg0149

Alternate gene names: 62389009

Gene position: 128005-127190 (Counterclockwise)

Preceding gene: 62389010

Following gene: 62389008

Centisome position: 3.9

GC content: 58.95

Gene sequence:

>816_bases
ATGCCCATGTCAGGCATTGATGCAAAGAAAATCCGCACCCGTCATTTCCGCGAAGCTAAAGTAAACGGCCAGAAAGTTTC
GGTTCTCACCAGCTATGATGCGCTTTCGGCGCGCATTTTTGATGAGGCTGGCGTCGATATGCTCCTTGTTGGTGATTCCG
CTGCCAACGTTGTGCTGGGTCGCGATACCACCTTGTCGATCACCTTGGATGAGATGATTGTGCTGGCCAAGGCGGTGACG
ATCGCTACGAAGCGTGCGCTTGTGGTGGTTGATCTGCCGTTTGGTACCTATGAGGTGAGCCCAAATCAGGCGGTGGAGTC
CGCGATCCGGGTCATGCGTGAAACGGGTGCGGCTGCGGTGAAGATCGAGGGTGGCGTGGAGATCGCGCAGACGATTCGAC
GCATTGTTGATGCTGGAATTCCGGTTGTCGGCCACATCGGGTACACCCCGCAGTCCGAGCATTCCTTGGGCGGCCACGTG
GTTCAGGGTCGTGGCGCGAGTTCTGGAAAGCTCATCGCCGATGCCCGCGCGTTGGAGCAGGCGGGTGCGTTTGCGGTTGT
GTTGGAGATGGTTCCAGCAGAGGCAGCGCGCGAGGTTACCGAGGATCTTTCCATCACCACTATCGGAATCGGTGCCGGCA
ATGGCACAGATGGGCAGGTTTTGGTGTGGCAGGATGCCTTCGGCCTCAACCGCGGCAAGAAGCCACGCTTCGTCCGCGAG
TACGCCACCTTGGGCGATTCCTTGCACGACGCCGCGCAGGCCTACATCGCCGATATCCACGCGGGTACCTTCCCAGGCGA
AGCGGAGTCCTTTTAA

Upstream 100 bases:

>100_bases
AAAATTTGACTCCATAACGAGAACTTAATCGAGCAACACCCCTGAACAGTGAATCAAATCGGAATTTATTTATTCTGAGC
TGGTCATCACATCTATACTC

Downstream 100 bases:

>100_bases
TGCAGGTAGCAACCACAAAGCAGGCGCTTATCGACGCCCTCCTCCACCACAAATCCGTCGGGCTCGTCCCCACCATGGGT
GCGCTACACAGCGGACACGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVT
IATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHV
VQGRGASSGKLIADARALEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
YATLGDSLHDAAQAYIADIHAGTFPGEAESF

Sequences:

>Translated_271_residues
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVT
IATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHV
VQGRGASSGKLIADARALEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
>Mature_270_residues
PMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSITLDEMIVLAKAVTI
ATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAVKIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVV
QGRGASSGKLIADARALEQAGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVREY
ATLGDSLHDAAQAYIADIHAGTFPGEAESF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=42.4124513618677, Blast_Score=205, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319653, Length=263, Percent_Identity=37.6425855513308, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28553; Mature: 28422

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLG
CCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCEEEEE
RDTTLSITLDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAV
CCCEEEEEHHHHHHHHHHHHHEECCEEEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEE
KIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASSGKLIADARALEQ
EECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEHHHHHHHH
AGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
CCHHEEEHHHHCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHH
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
HHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PMSGIDAKKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLG
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCEEEEE
RDTTLSITLDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAV
CCCEEEEEHHHHHHHHHHHHHEECCEEEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEE
KIEGGVEIAQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASSGKLIADARALEQ
EECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEHHHHHHHH
AGAFAVVLEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVRE
CCHHEEEHHHHCCHHHHHHHHCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHH
YATLGDSLHDAAQAYIADIHAGTFPGEAESF
HHHHCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA