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The map label for this gene is mtlD [H]

Identifier: 62389004

GI number: 62389004

Start: 120949

End: 122460

Strand: Reverse

Name: mtlD [H]

Synonym: cg0143

Alternate gene names: 62389004

Gene position: 122460-120949 (Counterclockwise)

Preceding gene: 62389005

Following gene: 62389003

Centisome position: 3.73

GC content: 56.22

Gene sequence:

>1512_bases
ATGAACACCCCACTCCAGCTCAACACTGAAAACCTGCAGGAAATCGCTTCGACTTCCGGAGTGCAGATCCCAGCGTTCAA
CCGCGCTGACGTCGCCCCGGGCATTGTCCACTTCGGTGTTGGCGGATTCCATCGCGCTCACCAAGCGATGTACCTCAATG
AATTGATGAATGAGGGCAAGGCCTTGGATTGGGGCATCATCGGCATGGGTGTCATGCCTTCCGATGTGCGCATGCGCGAT
GCCCTGGCCAGCCAAGATCACCTTTATACCCTGACCACTAAAGCTCCTGATGGAACTCTTGATCAAAAAATCATCGGATC
CATCATTGACTACGTGTTCGCTCCCGAGGACCCAGCACGGGCCGTTGCAACCCTCGCGCAGGACTCCATCCGCATTGTTT
CCCTCACGGTGACTGAAGGCGGATACAACATCGATCCGGCGACAGAAGATTTCGACCACACCAACCCTCGAATCGTTGCT
GACCGCGAAGCCCTGCAGGCGGGCGATACTTCCACTTTGCAGACCTTCTTTGGGTTGATCACTGCCGCATTGATTTCCCG
AAAAGAATCAGGATCTACGCCATTTACCATCATGAGCTGCGATAACATCCAAGGCAACGGCGATCTGGCTAAGCGTTTCT
TCCTCGCCTTCGCACATTCCGTGTCTTCTGAGCTCGGCGAATGGGTGGAAAACAACGTGGCCTTCCCCAACTCCATGGTG
GACCGCATCACCCCTGAAACCACCGACGGCGACCGCGATGACATCAAGGAAATCGGCTACATCGATGCGTGGCCAGTGGT
TTCTGAAGATTTCACCCAATGGGTCCTCGAGGATGCCTTCACCCAGGGCCGCCCCGCGTACGAGGAGGTTGGCGTGCAGG
TCGTCTCCGACGTGGAGCCTTATGAATTAATGAAGCTGCGCCTGCTCAACGCCTCCCACCAGGGACTTTGCTACTTCGGC
CACTTGGCTGGCCACCACATGGTCCACGACGTCATGGCGGATACCCGCTTCCAGGATTTCCTCCTGGCTTACATGGAGCG
CGAAGCCACCCCTACCCTCAAGGAACTTCCAGGTGTCGATCTAGATGCTTATCGACGCCAACTCATCGCGCGATTCGGCA
ACGCCGCAGTCAAAGACACCGTACCGCGCCTGTGTGCGGAATCCTCCGACCGCATTCCAAAGTGGCTGTTGCCAGTCGTA
CGCGAAAACCTCGCAGCAGGCCGCGACGTCACACTTTCTGCAGCCATCGTCGCATCCTGGGCGCGCTACGCAGAAGGCAC
CGACGAGCAGGGCAACCCAATAAAGATTGTTGACCGTTTGAGTGAGCGCGTCCAAGAAAACGCATCAGGAAATCGCACCG
ATATTTTGTCATTCATCCGCGACCGTGGAATCTTCGGAGACTTGGTCGATGCTGAACCATTCACCAAGGCATACTCCGAG
ACACTGTCCTCCCTTCATGACCGTGGCGCGGAAGCAACCATCGATGCACTTCTTACGCAGGTAACTGTCTAA

Upstream 100 bases:

>100_bases
CACTTGCTGAAGACGCCCACATCGAAGACCTTGCAGATGTAAACGCAAACGCCTAACTGTTTTTCGAGCTAAACCCATCC
TTGAAAGGATCTTTTCCACC

Downstream 100 bases:

>100_bases
ATCCGTTGCGCGCTAGGGTTGAGGCATGTCTCCCACACATCGCCTCGTCATCCTTAGACACGCCAAATCTTCCTGGTCCA
CCGGAGTACTCGACCATAAA

Product: mannitol 2-dehydrogenase

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MNTPLQLNTENLQEIASTSGVQIPAFNRADVAPGIVHFGVGGFHRAHQAMYLNELMNEGKALDWGIIGMGVMPSDVRMRD
ALASQDHLYTLTTKAPDGTLDQKIIGSIIDYVFAPEDPARAVATLAQDSIRIVSLTVTEGGYNIDPATEDFDHTNPRIVA
DREALQAGDTSTLQTFFGLITAALISRKESGSTPFTIMSCDNIQGNGDLAKRFFLAFAHSVSSELGEWVENNVAFPNSMV
DRITPETTDGDRDDIKEIGYIDAWPVVSEDFTQWVLEDAFTQGRPAYEEVGVQVVSDVEPYELMKLRLLNASHQGLCYFG
HLAGHHMVHDVMADTRFQDFLLAYMEREATPTLKELPGVDLDAYRRQLIARFGNAAVKDTVPRLCAESSDRIPKWLLPVV
RENLAAGRDVTLSAAIVASWARYAEGTDEQGNPIKIVDRLSERVQENASGNRTDILSFIRDRGIFGDLVDAEPFTKAYSE
TLSSLHDRGAEATIDALLTQVTV

Sequences:

>Translated_503_residues
MNTPLQLNTENLQEIASTSGVQIPAFNRADVAPGIVHFGVGGFHRAHQAMYLNELMNEGKALDWGIIGMGVMPSDVRMRD
ALASQDHLYTLTTKAPDGTLDQKIIGSIIDYVFAPEDPARAVATLAQDSIRIVSLTVTEGGYNIDPATEDFDHTNPRIVA
DREALQAGDTSTLQTFFGLITAALISRKESGSTPFTIMSCDNIQGNGDLAKRFFLAFAHSVSSELGEWVENNVAFPNSMV
DRITPETTDGDRDDIKEIGYIDAWPVVSEDFTQWVLEDAFTQGRPAYEEVGVQVVSDVEPYELMKLRLLNASHQGLCYFG
HLAGHHMVHDVMADTRFQDFLLAYMEREATPTLKELPGVDLDAYRRQLIARFGNAAVKDTVPRLCAESSDRIPKWLLPVV
RENLAAGRDVTLSAAIVASWARYAEGTDEQGNPIKIVDRLSERVQENASGNRTDILSFIRDRGIFGDLVDAEPFTKAYSE
TLSSLHDRGAEATIDALLTQVTV
>Mature_503_residues
MNTPLQLNTENLQEIASTSGVQIPAFNRADVAPGIVHFGVGGFHRAHQAMYLNELMNEGKALDWGIIGMGVMPSDVRMRD
ALASQDHLYTLTTKAPDGTLDQKIIGSIIDYVFAPEDPARAVATLAQDSIRIVSLTVTEGGYNIDPATEDFDHTNPRIVA
DREALQAGDTSTLQTFFGLITAALISRKESGSTPFTIMSCDNIQGNGDLAKRFFLAFAHSVSSELGEWVENNVAFPNSMV
DRITPETTDGDRDDIKEIGYIDAWPVVSEDFTQWVLEDAFTQGRPAYEEVGVQVVSDVEPYELMKLRLLNASHQGLCYFG
HLAGHHMVHDVMADTRFQDFLLAYMEREATPTLKELPGVDLDAYRRQLIARFGNAAVKDTVPRLCAESSDRIPKWLLPVV
RENLAAGRDVTLSAAIVASWARYAEGTDEQGNPIKIVDRLSERVQENASGNRTDILSFIRDRGIFGDLVDAEPFTKAYSE
TLSSLHDRGAEATIDALLTQVTV

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=479, Percent_Identity=37.7870563674322, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1787823, Length=479, Percent_Identity=38.8308977035491, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1790779, Length=480, Percent_Identity=37.9166666666667, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790028, Length=230, Percent_Identity=28.2608695652174, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI48994885, Length=459, Percent_Identity=24.1830065359477, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324401, Length=503, Percent_Identity=40.3578528827038, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320765, Length=503, Percent_Identity=40.3578528827038, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 55370; Mature: 55370

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPLQLNTENLQEIASTSGVQIPAFNRADVAPGIVHFGVGGFHRAHQAMYLNELMNEGK
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
ALDWGIIGMGVMPSDVRMRDALASQDHLYTLTTKAPDGTLDQKIIGSIIDYVFAPEDPAR
CCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHH
AVATLAQDSIRIVSLTVTEGGYNIDPATEDFDHTNPRIVADREALQAGDTSTLQTFFGLI
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHCCCHHHHHHHHHHH
TAALISRKESGSTPFTIMSCDNIQGNGDLAKRFFLAFAHSVSSELGEWVENNVAFPNSMV
HHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DRITPETTDGDRDDIKEIGYIDAWPVVSEDFTQWVLEDAFTQGRPAYEEVGVQVVSDVEP
HHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCH
YELMKLRLLNASHQGLCYFGHLAGHHMVHDVMADTRFQDFLLAYMEREATPTLKELPGVD
HHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCC
LDAYRRQLIARFGNAAVKDTVPRLCAESSDRIPKWLLPVVRENLAAGRDVTLSAAIVASW
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ARYAEGTDEQGNPIKIVDRLSERVQENASGNRTDILSFIRDRGIFGDLVDAEPFTKAYSE
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TLSSLHDRGAEATIDALLTQVTV
HHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNTPLQLNTENLQEIASTSGVQIPAFNRADVAPGIVHFGVGGFHRAHQAMYLNELMNEGK
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
ALDWGIIGMGVMPSDVRMRDALASQDHLYTLTTKAPDGTLDQKIIGSIIDYVFAPEDPAR
CCCCEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHH
AVATLAQDSIRIVSLTVTEGGYNIDPATEDFDHTNPRIVADREALQAGDTSTLQTFFGLI
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHHCCCHHHHHHHHHHH
TAALISRKESGSTPFTIMSCDNIQGNGDLAKRFFLAFAHSVSSELGEWVENNVAFPNSMV
HHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DRITPETTDGDRDDIKEIGYIDAWPVVSEDFTQWVLEDAFTQGRPAYEEVGVQVVSDVEP
HHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCH
YELMKLRLLNASHQGLCYFGHLAGHHMVHDVMADTRFQDFLLAYMEREATPTLKELPGVD
HHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCC
LDAYRRQLIARFGNAAVKDTVPRLCAESSDRIPKWLLPVVRENLAAGRDVTLSAAIVASW
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ARYAEGTDEQGNPIKIVDRLSERVQENASGNRTDILSFIRDRGIFGDLVDAEPFTKAYSE
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TLSSLHDRGAEATIDALLTQVTV
HHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]