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The map label for this gene is groL3 [H]

Identifier: 62185439

GI number: 62185439

Start: 966499

End: 968025

Strand: Direct

Name: groL3 [H]

Synonym: CAB836

Alternate gene names: 62185439

Gene position: 966499-968025 (Clockwise)

Preceding gene: 62185431

Following gene: 62185440

Centisome position: 84.46

GC content: 38.77

Gene sequence:

>1527_bases
ATGTTAGACAAGGAAAATTCCCTGTACGATACAGATAAAAAACTTTTCCATGGTATAGATCAAGTCTTTCATTCTATCAA
GGATCATTATGGTCCTCGAATTTCCTCTCGCTCTTTCTTCGAGAATCAAGGCTATCTGGTCTTATCGCGCATCACTCTTG
TGGATCCTTATGAAAACATTGGTGTGGATTTTGTCAAAGCTATGGCTAAGCACATTCATAAGAAATATCTTGATGGTGTA
ACGACTGGTATCATTTTACTTTATACTCTTCTCAAGGAAAGCTACTTTTTTTTAGATCAAGGCTTATCGCTGTATAAACT
CTGCTTTGCGTTAAGAAAAATGAGCGAAAAGCTTTTAACATCTTTGAAAAAGCATGCCTGGCCTTTAAAAGATGGGAATA
AAGCGAAAGGCATTGTTTTCTCTGCCCTTCCAGATTTAACGATTGCCACAGAAATGGCTGAGGCTTTTTCATCTGTCGGT
TCTGATGGATTTATATCATTATCACAACTGGAGATGTCTCATATGCAGATCACACAAGGATTACAAATCCCTTGTGGCTA
TATTTCTCCTTACTTCATTTCTCCATCTCCCCAGAGGATCCTCACACTTTCACAACCTCGTGTTTTCGTTACTGACAAAA
AAATTTCTACCTTCCTTAGTTTTCTTCCTCTATTGCAAGAGTTACGTGAACATGGAGAACATTTACTGATTTTTTGTAAC
GGTATAGATCCGGATGTTCTTTCTACATTCACTGTGAATAAACTTGAAGATCTCCTCGACATTGTTGTTGTTGATTTGAG
TAGACACCCGGATCTTGATCCCTCGTTGTTTGAGGATATCACCTTATTCACAGGAACGAATGTGTTCTCTCAGGATTTTT
CTCCAACCATACGGTTGCCCGAGCGTGTATCTTTAGGTTCATGTGCTTCTATAAAAATTTCCGAAGAAGAAACCATCATC
ATTCGTGGGCATAGTGTTTCTGAAGTTTTAGCATTAAAAATACACCAAATCGAAGAAGAAATTCGCACGAGCTCCTGTCA
GGAGAGAAAAACTACATTAATCAAGAGAAAGCACCGCTTACAGAGTTCTGTTGCTATAGTCCCTGTACGCGAAGAAAATA
AACTTTTCTATTCTTTAGCCCTTTCCACATTAACTGCTGCGGTAGACAAAGGCTACATTCCTGGAGGAGGTGCGGGTCTA
TTTTATGCTTCTTTACATCTATGTGATCAGGAAGAACTCTCAGAAGAAGAACGAGCAGCCATAAAGATTTTACACATGTG
TTGTCGAGCTCCTTTAGAACAACTCATCAGCAATATGAAACTAGAAAGCCAGGTCGTTCTAGATAAACTGTTATCTCTAT
CCACACCTAGTTTAGGGATGAATGTCATTTCTCAACAAATTGAAGACCTTATTGCCTCAGGCATTCTAGATCCTCTATCC
AAAATCGAGGATATTTTCTCCTTAGCCTTGGAAACAGGATTGAAAATCCTATCCTCAAAAGTCATCATTACCCATGCCGA
CAAATAA

Upstream 100 bases:

>100_bases
GGTGCCACCTTTCTTTTTACCTTTTTTATCTAAGGTATTGTGCACTAAAAAATGACTTGGTAGTGTGAATTTTTCCTAAG
GTTTCTCTTGGAGACTACCC

Downstream 100 bases:

>100_bases
ACTATTCTCTACGCTTAGGTGAAAACATCTTTTCTTTATGCCAACGGTTCGTCTGACAGACTGAAAAGCCTAAAATCCTA
GCCCCATCCCATAAGATCTG

Product: putative chaperonin

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3 [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MLDKENSLYDTDKKLFHGIDQVFHSIKDHYGPRISSRSFFENQGYLVLSRITLVDPYENIGVDFVKAMAKHIHKKYLDGV
TTGIILLYTLLKESYFFLDQGLSLYKLCFALRKMSEKLLTSLKKHAWPLKDGNKAKGIVFSALPDLTIATEMAEAFSSVG
SDGFISLSQLEMSHMQITQGLQIPCGYISPYFISPSPQRILTLSQPRVFVTDKKISTFLSFLPLLQELREHGEHLLIFCN
GIDPDVLSTFTVNKLEDLLDIVVVDLSRHPDLDPSLFEDITLFTGTNVFSQDFSPTIRLPERVSLGSCASIKISEEETII
IRGHSVSEVLALKIHQIEEEIRTSSCQERKTTLIKRKHRLQSSVAIVPVREENKLFYSLALSTLTAAVDKGYIPGGGAGL
FYASLHLCDQEELSEEERAAIKILHMCCRAPLEQLISNMKLESQVVLDKLLSLSTPSLGMNVISQQIEDLIASGILDPLS
KIEDIFSLALETGLKILSSKVIITHADK

Sequences:

>Translated_508_residues
MLDKENSLYDTDKKLFHGIDQVFHSIKDHYGPRISSRSFFENQGYLVLSRITLVDPYENIGVDFVKAMAKHIHKKYLDGV
TTGIILLYTLLKESYFFLDQGLSLYKLCFALRKMSEKLLTSLKKHAWPLKDGNKAKGIVFSALPDLTIATEMAEAFSSVG
SDGFISLSQLEMSHMQITQGLQIPCGYISPYFISPSPQRILTLSQPRVFVTDKKISTFLSFLPLLQELREHGEHLLIFCN
GIDPDVLSTFTVNKLEDLLDIVVVDLSRHPDLDPSLFEDITLFTGTNVFSQDFSPTIRLPERVSLGSCASIKISEEETII
IRGHSVSEVLALKIHQIEEEIRTSSCQERKTTLIKRKHRLQSSVAIVPVREENKLFYSLALSTLTAAVDKGYIPGGGAGL
FYASLHLCDQEELSEEERAAIKILHMCCRAPLEQLISNMKLESQVVLDKLLSLSTPSLGMNVISQQIEDLIASGILDPLS
KIEDIFSLALETGLKILSSKVIITHADK
>Mature_508_residues
MLDKENSLYDTDKKLFHGIDQVFHSIKDHYGPRISSRSFFENQGYLVLSRITLVDPYENIGVDFVKAMAKHIHKKYLDGV
TTGIILLYTLLKESYFFLDQGLSLYKLCFALRKMSEKLLTSLKKHAWPLKDGNKAKGIVFSALPDLTIATEMAEAFSSVG
SDGFISLSQLEMSHMQITQGLQIPCGYISPYFISPSPQRILTLSQPRVFVTDKKISTFLSFLPLLQELREHGEHLLIFCN
GIDPDVLSTFTVNKLEDLLDIVVVDLSRHPDLDPSLFEDITLFTGTNVFSQDFSPTIRLPERVSLGSCASIKISEEETII
IRGHSVSEVLALKIHQIEEEIRTSSCQERKTTLIKRKHRLQSSVAIVPVREENKLFYSLALSTLTAAVDKGYIPGGGAGL
FYASLHLCDQEELSEEERAAIKILHMCCRAPLEQLISNMKLESQVVLDKLLSLSTPSLGMNVISQQIEDLIASGILDPLS
KIEDIFSLALETGLKILSSKVIITHADK

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=512, Percent_Identity=23.828125, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI31542947, Length=512, Percent_Identity=23.828125, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1790586, Length=487, Percent_Identity=26.2833675564682, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17555558, Length=466, Percent_Identity=24.2489270386266, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI193210679, Length=175, Percent_Identity=25.1428571428571, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=491, Percent_Identity=25.8655804480652, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24641193, Length=484, Percent_Identity=25.8264462809917, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24641191, Length=484, Percent_Identity=25.8264462809917, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45550936, Length=511, Percent_Identity=23.8747553816047, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI45550132, Length=511, Percent_Identity=23.8747553816047, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI45550935, Length=511, Percent_Identity=23.8747553816047, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17864606, Length=513, Percent_Identity=22.2222222222222, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24584129, Length=514, Percent_Identity=22.568093385214, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921262, Length=514, Percent_Identity=22.568093385214, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56853; Mature: 56853

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKENSLYDTDKKLFHGIDQVFHSIKDHYGPRISSRSFFENQGYLVLSRITLVDPYENI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEEEECCHHHC
GVDFVKAMAKHIHKKYLDGVTTGIILLYTLLKESYFFLDQGLSLYKLCFALRKMSEKLLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SLKKHAWPLKDGNKAKGIVFSALPDLTIATEMAEAFSSVGSDGFISLSQLEMSHMQITQG
HHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCC
LQIPCGYISPYFISPSPQRILTLSQPRVFVTDKKISTFLSFLPLLQELREHGEHLLIFCN
CCCCCCCCCCEEECCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GIDPDVLSTFTVNKLEDLLDIVVVDLSRHPDLDPSLFEDITLFTGTNVFSQDFSPTIRLP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCHHHCCCCCCCCCC
ERVSLGSCASIKISEEETIIIRGHSVSEVLALKIHQIEEEIRTSSCQERKTTLIKRKHRL
CCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSSVAIVPVREENKLFYSLALSTLTAAVDKGYIPGGGAGLFYASLHLCDQEELSEEERAA
HCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCHHHHHH
IKILHMCCRAPLEQLISNMKLESQVVLDKLLSLSTPSLGMNVISQQIEDLIASGILDPLS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KIEDIFSLALETGLKILSSKVIITHADK
HHHHHHHHHHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure
MLDKENSLYDTDKKLFHGIDQVFHSIKDHYGPRISSRSFFENQGYLVLSRITLVDPYENI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEEEEECCHHHC
GVDFVKAMAKHIHKKYLDGVTTGIILLYTLLKESYFFLDQGLSLYKLCFALRKMSEKLLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SLKKHAWPLKDGNKAKGIVFSALPDLTIATEMAEAFSSVGSDGFISLSQLEMSHMQITQG
HHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCC
LQIPCGYISPYFISPSPQRILTLSQPRVFVTDKKISTFLSFLPLLQELREHGEHLLIFCN
CCCCCCCCCCEEECCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GIDPDVLSTFTVNKLEDLLDIVVVDLSRHPDLDPSLFEDITLFTGTNVFSQDFSPTIRLP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCHHHCCCCCCCCCC
ERVSLGSCASIKISEEETIIIRGHSVSEVLALKIHQIEEEIRTSSCQERKTTLIKRKHRL
CCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSSVAIVPVREENKLFYSLALSTLTAAVDKGYIPGGGAGLFYASLHLCDQEELSEEERAA
HCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCHHHHHH
IKILHMCCRAPLEQLISNMKLESQVVLDKLLSLSTPSLGMNVISQQIEDLIASGILDPLS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KIEDIFSLALETGLKILSSKVIITHADK
HHHHHHHHHHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA