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The map label for this gene is bioA [H]

Identifier: 62185301

GI number: 62185301

Start: 798407

End: 799684

Strand: Direct

Name: bioA [H]

Synonym: CAB688

Alternate gene names: 62185301

Gene position: 798407-799684 (Clockwise)

Preceding gene: 62185300

Following gene: 62185302

Centisome position: 69.77

GC content: 40.69

Gene sequence:

>1278_bases
ATGTTGACAGATCTAAAAAATGAGAAAAAACAATCTAAAATATGGCATCCCTTTGCTCAACCTGGTTTAGATCACAAACC
TATCCACATTGTACGTGGAGAAGGTGCTTATCTCTATACACAATCGGGAACTGCTTATCTTGACGCTATTTCTTCATGGT
GGTGTAATCTTCATGGTCACGCTCATCCCTATATTGCGCAAAAAATCTCAGAACAAGCATACCAACTTGAGCATGTAATT
TTTTCTAATATCACACATACTCCCGCTGAAGAACTTTCTCAAAGACTTACAGAACTCCTTCCGGAGGGTTTAGAACGTTG
TTTCTTCTCTGATAATGGCGCCTGTTCCATAGAAATCGCTTTAAAAATCACACTGCAATACTTGTACAATCAAGGAAGAC
CAAAAACACGTTTTGTGTCTTTCAAACATGGCTACCATGGGGATACTTTCGGAGCTATGTCCATAGCAGGCCCGACAGAT
ATCAATCAACCTTTCCAATCTCTATTGTTCTCTGCGGACACTATAGATCCTCCCTACTATGGGAAAGAAGATATCTCTTT
ACAACAAGCAAAAGCTCTATTTTCCACAGGAGAAATTGCAGGATTTATTTACGAGCCGATCTTACAAGGTACAGGAGGCA
TGCGTGTGTACAATCCTGAAGGCTTAGATGCCATTTTGGCACTCGCCAAACACTATGATGTGTTGTGCATAGCCGATGAA
ATTCTTACAGGGTTTGGACGCACAGGACCATTGTTTGCTTCAGAGTACATGAAAACTCACCCAGATATCCTTTGTCTTTC
TAAAGGATTAACAGGTGGATTTCTTCCCCTGGCTGTTACTGTAGTACGCGAAGAAATTTATCAAGCTTTTGTAGCTAAGG
ATCGTAGATTAGCGTTTCTACATGGCCATACCTATACAGGGAATCCCTTAGGGTGTGCTGCAGCCTTAGCATCTTTGGAT
CTCACATTATCTCCTCAGTGCAAACAGCAACGTGAAATGATAGAAACTTGTCATAAGCAATTCCAATCACAATACGGATC
GCTATGGCAACGCTGTGATGTCTTAGGAACGGTACTCGCTGTAGATTATCCAACCAAATCTTTAGGATATTTCTCCAATT
TACGTGATACCCTTTATAACTTTTTTATAGAGAATCACCTCATTCTACGCCCTTTAGGCCATACTATTTATGTCCTTCCT
CCCTACTGTATCCACGAGGAAGACCTGCATCGAATTTATCATTACCTCCAGGAGATTCTATGCTTACAAATACAATAA

Upstream 100 bases:

>100_bases
TTTTGGGACGTTTGAATTATGAAAAGAGTATTTCCAAAGCTACAGTACAAAACTACGCAAATTTATGGAAAGAAACCTGG
AAATATAGAGACACACTGTT

Downstream 100 bases:

>100_bases
CCACCTTTGTATCTTACGCATCACGTTGGCCATCTGTCCTGAAACATATCGTTGAGGATAACGAGTTACATAGCAAGTGG
GTAAATACACTATCATTTTT

Product: putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLTDLKNEKKQSKIWHPFAQPGLDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGHAHPYIAQKISEQAYQLEHVI
FSNITHTPAEELSQRLTELLPEGLERCFFSDNGACSIEIALKITLQYLYNQGRPKTRFVSFKHGYHGDTFGAMSIAGPTD
INQPFQSLLFSADTIDPPYYGKEDISLQQAKALFSTGEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIADE
ILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKDRRLAFLHGHTYTGNPLGCAAALASLD
LTLSPQCKQQREMIETCHKQFQSQYGSLWQRCDVLGTVLAVDYPTKSLGYFSNLRDTLYNFFIENHLILRPLGHTIYVLP
PYCIHEEDLHRIYHYLQEILCLQIQ

Sequences:

>Translated_425_residues
MLTDLKNEKKQSKIWHPFAQPGLDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGHAHPYIAQKISEQAYQLEHVI
FSNITHTPAEELSQRLTELLPEGLERCFFSDNGACSIEIALKITLQYLYNQGRPKTRFVSFKHGYHGDTFGAMSIAGPTD
INQPFQSLLFSADTIDPPYYGKEDISLQQAKALFSTGEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIADE
ILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKDRRLAFLHGHTYTGNPLGCAAALASLD
LTLSPQCKQQREMIETCHKQFQSQYGSLWQRCDVLGTVLAVDYPTKSLGYFSNLRDTLYNFFIENHLILRPLGHTIYVLP
PYCIHEEDLHRIYHYLQEILCLQIQ
>Mature_425_residues
MLTDLKNEKKQSKIWHPFAQPGLDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGHAHPYIAQKISEQAYQLEHVI
FSNITHTPAEELSQRLTELLPEGLERCFFSDNGACSIEIALKITLQYLYNQGRPKTRFVSFKHGYHGDTFGAMSIAGPTD
INQPFQSLLFSADTIDPPYYGKEDISLQQAKALFSTGEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIADE
ILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKDRRLAFLHGHTYTGNPLGCAAALASLD
LTLSPQCKQQREMIETCHKQFQSQYGSLWQRCDVLGTVLAVDYPTKSLGYFSNLRDTLYNFFIENHLILRPLGHTIYVLP
PYCIHEEDLHRIYHYLQEILCLQIQ

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=302, Percent_Identity=29.8013245033113, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=26.7605633802817, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI13994255, Length=345, Percent_Identity=28.695652173913, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=25.5269320843091, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=25.531914893617, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=25.8227848101266, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=26.4797507788162, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=36.5617433414044, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=28.7469287469287, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=28.8888888888889, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788044, Length=349, Percent_Identity=31.5186246418338, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789016, Length=304, Percent_Identity=28.2894736842105, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787560, Length=294, Percent_Identity=29.2517006802721, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786349, Length=327, Percent_Identity=27.82874617737, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=25.3694581280788, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=281, Percent_Identity=26.6903914590747, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=22.9545454545455, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=31.7286652078775, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=28.1725888324873, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=26.1501210653753, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356575, Length=435, Percent_Identity=27.3563218390805, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI161085790, Length=367, Percent_Identity=29.1553133514986, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28574759, Length=367, Percent_Identity=29.1553133514986, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47957; Mature: 47957

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDLKNEKKQSKIWHPFAQPGLDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGH
CCCCCCCHHHHHHCCCCHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCCC
AHPYIAQKISEQAYQLEHVIFSNITHTPAEELSQRLTELLPEGLERCFFSDNGACSIEIA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
LKITLQYLYNQGRPKTRFVSFKHGYHGDTFGAMSIAGPTDINQPFQSLLFSADTIDPPYY
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCC
GKEDISLQQAKALFSTGEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIADE
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEHHH
ILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKDRRLAFL
HHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
HGHTYTGNPLGCAAALASLDLTLSPQCKQQREMIETCHKQFQSQYGSLWQRCDVLGTVLA
ECCCCCCCCHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VDYPTKSLGYFSNLRDTLYNFFIENHLILRPLGHTIYVLPPYCIHEEDLHRIYHYLQEIL
ECCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHCCHHHHHHHHHHHHHHH
CLQIQ
HHCCC
>Mature Secondary Structure
MLTDLKNEKKQSKIWHPFAQPGLDHKPIHIVRGEGAYLYTQSGTAYLDAISSWWCNLHGH
CCCCCCCHHHHHHCCCCHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCCC
AHPYIAQKISEQAYQLEHVIFSNITHTPAEELSQRLTELLPEGLERCFFSDNGACSIEIA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
LKITLQYLYNQGRPKTRFVSFKHGYHGDTFGAMSIAGPTDINQPFQSLLFSADTIDPPYY
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCC
GKEDISLQQAKALFSTGEIAGFIYEPILQGTGGMRVYNPEGLDAILALAKHYDVLCIADE
CCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEHHH
ILTGFGRTGPLFASEYMKTHPDILCLSKGLTGGFLPLAVTVVREEIYQAFVAKDRRLAFL
HHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
HGHTYTGNPLGCAAALASLDLTLSPQCKQQREMIETCHKQFQSQYGSLWQRCDVLGTVLA
ECCCCCCCCHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VDYPTKSLGYFSNLRDTLYNFFIENHLILRPLGHTIYVLPPYCIHEEDLHRIYHYLQEIL
ECCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCHHCCHHHHHHHHHHHHHHH
CLQIQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]