Click here to switch to the map view.

The map label for this gene is srp54

Identifier: 60623872

GI number: 60623872

Start: 1296894

End: 1298231

Strand: Direct

Name: srp54

Synonym: ST1297

Alternate gene names: 60623872

Gene position: 1296894-1298231 (Clockwise)

Preceding gene: 15921562

Following gene: 15921564

Centisome position: 48.13

GC content: 32.29

Gene sequence:

>1338_bases
TTGTTAGATAATTTAAAAGACGCAGTTAGAAAATTTTTAGGTTCCTCTAATTATGATAAAGCAGTAAATGACTTTATAAA
GGAACTTCAAATTTCTTTAATTAAATCAGATGTAAATGTAAAACTTGTAAGTAATTTAACACAAAAAATAAAAGACAGAC
TTGAAAAAGAAAAACCACCCACAGCAATAGAGAGAAGAGAATGGTTTATCTCTATTGTATATGATGAATTATCTAAATTA
TTTGGTGGTGATATAAACCCAGAAGTCATGCCTAAGAAGATTCCTTATGTGATAATGTTAGTAGGCGTTCAAGGAAGTGG
TAAAACTACAACAGCAGGTAAATTAGCTCTATTTTATAAGAAAAAAGGATATAAAGTTGGATTGGTTGCCGCTGATGTAT
ATAGACCAGCAGCATATGACCAATTGGTCCAGATAGGTAAACAAATAAATGTTCCAGTATATGGAGAGCCAAATAATACA
GATGCCGTTGGGATAGCAAAAAGAGGAGTTGAGAAGTTCCTATCTGAAAAATACGATATTATTATTGTTGATACAGCTGG
TAGACATGGATATGGTGAGGAAGTAAAACTTTTAGAAGAAATGAAAAATATGTATAGTGAGATTAAACCAGATGAAGTAA
TCTTGGTAATAGATGCTTCAATAGGTCAAAAAGCCTATGATTTGGCTTCTAGATTTCATCAAGCAAGTCCCATAGGGTCA
ATTATAGTAACAAAAATGGACGGAACGGCTAAAGGTGGTGGAGCTCTTTCTGCTGTAGCTGCTACTGGTGCTGCTATAAA
ATTCATAGGTACTGGAGAAAAATTAGATGAGCTAGAAGTCTTTAATCCGCGAAGATTTGTTTCACGTATCTTAGGAATGG
GAGACATAGAGAGCATTATAGAAAAAATCAAGGGAATGGAAGAATATGAGCAGATTCAAAAGAAAATGGAAGAGGTTATG
AGTGGAAAAGCCAAATTGACCTTAAGAGATATTTACAAGCAATTAACAGCTCTAAGAAAGATGGGTCCTTTAAATAAGAT
TTTGCAAATGTTACCAGGCTTTGGAGTTTTTTCTCAAATTCCAGAAGAACAATTGAAATTAGGAGAAGAGAAGATTAAAA
AATTTCTTGTAATTATGAACTCTATGACATATAAAGAGTTAGATAATCCTTCAATAATAGATAAATCTAGAATAAGAAGA
ATAGCAAAAGGTTCTGGTACTTCGCCAGAGGAAGTAAAGGAATTATTAAAGCAATATCAAGTAACTAATAATTTGTTAAA
AATGGTTAAGAGGAGAAAAGGTCTTGCAAAACTTTTTGAAGACAGAAATTCTAAGTAA

Upstream 100 bases:

>100_bases
AAACCAACAGATGCAGATATAGTTGATAAAATTAGGCCAGGAGCAGAGGTAGAGTATTGGGAAATTATGGGTAGAAAGAA
AATTGTTAGGGTAAAGTAAA

Downstream 100 bases:

>100_bases
ATCACTAGAGTTATTATCTAAGTATCCTCTTTGTGATAGTTGTCTAGGAAGATGTTTTGCAAGGCTCAGTTTAGGTCATA
GTAATGAAGAAAGAGGTAAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLDNLKDAVRKFLGSSNYDKAVNDFIKELQISLIKSDVNVKLVSNLTQKIKDRLEKEKPPTAIERREWFISIVYDELSKL
FGGDINPEVMPKKIPYVIMLVGVQGSGKTTTAGKLALFYKKKGYKVGLVAADVYRPAAYDQLVQIGKQINVPVYGEPNNT
DAVGIAKRGVEKFLSEKYDIIIVDTAGRHGYGEEVKLLEEMKNMYSEIKPDEVILVIDASIGQKAYDLASRFHQASPIGS
IIVTKMDGTAKGGGALSAVAATGAAIKFIGTGEKLDELEVFNPRRFVSRILGMGDIESIIEKIKGMEEYEQIQKKMEEVM
SGKAKLTLRDIYKQLTALRKMGPLNKILQMLPGFGVFSQIPEEQLKLGEEKIKKFLVIMNSMTYKELDNPSIIDKSRIRR
IAKGSGTSPEEVKELLKQYQVTNNLLKMVKRRKGLAKLFEDRNSK

Sequences:

>Translated_445_residues
MLDNLKDAVRKFLGSSNYDKAVNDFIKELQISLIKSDVNVKLVSNLTQKIKDRLEKEKPPTAIERREWFISIVYDELSKL
FGGDINPEVMPKKIPYVIMLVGVQGSGKTTTAGKLALFYKKKGYKVGLVAADVYRPAAYDQLVQIGKQINVPVYGEPNNT
DAVGIAKRGVEKFLSEKYDIIIVDTAGRHGYGEEVKLLEEMKNMYSEIKPDEVILVIDASIGQKAYDLASRFHQASPIGS
IIVTKMDGTAKGGGALSAVAATGAAIKFIGTGEKLDELEVFNPRRFVSRILGMGDIESIIEKIKGMEEYEQIQKKMEEVM
SGKAKLTLRDIYKQLTALRKMGPLNKILQMLPGFGVFSQIPEEQLKLGEEKIKKFLVIMNSMTYKELDNPSIIDKSRIRR
IAKGSGTSPEEVKELLKQYQVTNNLLKMVKRRKGLAKLFEDRNSK
>Mature_445_residues
MLDNLKDAVRKFLGSSNYDKAVNDFIKELQISLIKSDVNVKLVSNLTQKIKDRLEKEKPPTAIERREWFISIVYDELSKL
FGGDINPEVMPKKIPYVIMLVGVQGSGKTTTAGKLALFYKKKGYKVGLVAADVYRPAAYDQLVQIGKQINVPVYGEPNNT
DAVGIAKRGVEKFLSEKYDIIIVDTAGRHGYGEEVKLLEEMKNMYSEIKPDEVILVIDASIGQKAYDLASRFHQASPIGS
IIVTKMDGTAKGGGALSAVAATGAAIKFIGTGEKLDELEVFNPRRFVSRILGMGDIESIIEKIKGMEEYEQIQKKMEEVM
SGKAKLTLRDIYKQLTALRKMGPLNKILQMLPGFGVFSQIPEEQLKLGEEKIKKFLVIMNSMTYKELDNPSIIDKSRIRR
IAKGSGTSPEEVKELLKQYQVTNNLLKMVKRRKGLAKLFEDRNSK

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=430, Percent_Identity=42.093023255814, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI226371618, Length=398, Percent_Identity=42.4623115577889, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI89061728, Length=143, Percent_Identity=53.8461538461538, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI23308697, Length=224, Percent_Identity=27.2321428571429, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI295424842, Length=224, Percent_Identity=27.2321428571429, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=35.5971896955504, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789874, Length=270, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=448, Percent_Identity=38.3928571428571, Blast_Score=319, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=428, Percent_Identity=42.2897196261682, Blast_Score=325, Evalue=9e-90,
Organism=Saccharomyces cerevisiae, GI6320498, Length=308, Percent_Identity=26.2987012987013, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17647949, Length=425, Percent_Identity=40, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24641198, Length=221, Percent_Identity=28.9592760180996, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_SULTO (Q971S9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377232.2
- ProteinModelPortal:   Q971S9
- SMR:   Q971S9
- GeneID:   1459299
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1297
- NMPDR:   fig|273063.1.peg.1400
- HOGENOM:   HBG562580
- ProtClustDB:   PRK00771
- BioCyc:   STOK273063:ST1297-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49823; Mature: 49823

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNLKDAVRKFLGSSNYDKAVNDFIKELQISLIKSDVNVKLVSNLTQKIKDRLEKEKPP
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
TAIERREWFISIVYDELSKLFGGDINPEVMPKKIPYVIMLVGVQGSGKTTTAGKLALFYK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEE
KKGYKVGLVAADVYRPAAYDQLVQIGKQINVPVYGEPNNTDAVGIAKRGVEKFLSEKYDI
CCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCE
IIVDTAGRHGYGEEVKLLEEMKNMYSEIKPDEVILVIDASIGQKAYDLASRFHQASPIGS
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
IIVTKMDGTAKGGGALSAVAATGAAIKFIGTGEKLDELEVFNPRRFVSRILGMGDIESII
EEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCHHHHH
EKIKGMEEYEQIQKKMEEVMSGKAKLTLRDIYKQLTALRKMGPLNKILQMLPGFGVFSQI
HHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHC
PEEQLKLGEEKIKKFLVIMNSMTYKELDNPSIIDKSRIRRIAKGSGTSPEEVKELLKQYQ
CHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
VTNNLLKMVKRRKGLAKLFEDRNSK
HHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDNLKDAVRKFLGSSNYDKAVNDFIKELQISLIKSDVNVKLVSNLTQKIKDRLEKEKPP
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
TAIERREWFISIVYDELSKLFGGDINPEVMPKKIPYVIMLVGVQGSGKTTTAGKLALFYK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEE
KKGYKVGLVAADVYRPAAYDQLVQIGKQINVPVYGEPNNTDAVGIAKRGVEKFLSEKYDI
CCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCE
IIVDTAGRHGYGEEVKLLEEMKNMYSEIKPDEVILVIDASIGQKAYDLASRFHQASPIGS
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCC
IIVTKMDGTAKGGGALSAVAATGAAIKFIGTGEKLDELEVFNPRRFVSRILGMGDIESII
EEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCHHHHH
EKIKGMEEYEQIQKKMEEVMSGKAKLTLRDIYKQLTALRKMGPLNKILQMLPGFGVFSQI
HHHHCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHC
PEEQLKLGEEKIKKFLVIMNSMTYKELDNPSIIDKSRIRRIAKGSGTSPEEVKELLKQYQ
CHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
VTNNLLKMVKRRKGLAKLFEDRNSK
HHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479