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The map label for this gene is eif5a

Identifier: 15921562

GI number: 15921562

Start: 1296497

End: 1296892

Strand: Direct

Name: eif5a

Synonym: ST1296

Alternate gene names: 15921562

Gene position: 1296497-1296892 (Clockwise)

Preceding gene: 15921561

Following gene: 60623872

Centisome position: 48.11

GC content: 35.1

Gene sequence:

>396_bases
ATGAGCATTCAATACACGACTGTAGGTGATCTAAAGGTAGGTAATTATGTAGTTATTGATGGTGAACCTTGTAGAGTAGT
TGAGATAAGTAAGGCCAAAACTGGAAAACATGGAAGCGCTAAAGCTAATATCGTTGCGATAGGTCTTTTCACTGGTCAAA
AAAGAACACTAATGGCACCAGTAGATCAACAAGTAGAAGTTCCGATAATTGAAAAACATATAGGTCAAATTTTGGCTGAT
AAAGGTGATACAATTACGATTATGGATATGGAAAATTATGAGACATTTGACATAGAAAAACCAACAGATGCAGATATAGT
TGATAAAATTAGGCCAGGAGCAGAGGTAGAGTATTGGGAAATTATGGGTAGAAAGAAAATTGTTAGGGTAAAGTAA

Upstream 100 bases:

>100_bases
GCTGTGAAGAGGCTAGATATACTGAATTTGTGATGAAGGGCCAAAGCTCGGAGCAAAGAGTTTATAGCTTTGCCTTAATT
AGGTTATTTTGGGAATATAA

Downstream 100 bases:

>100_bases
ATTGTTAGATAATTTAAAAGACGCAGTTAGAAAATTTTTAGGTTCCTCTAATTATGATAAAGCAGTAAATGACTTTATAA
AGGAACTTCAAATTTCTTTA

Product: translation initiation factor IF-5A

Products: NA

Alternate protein names: Hypusine-containing protein; eIF-5A

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MSIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAPVDQQVEVPIIEKHIGQILAD
KGDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWEIMGRKKIVRVK

Sequences:

>Translated_131_residues
MSIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAPVDQQVEVPIIEKHIGQILAD
KGDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWEIMGRKKIVRVK
>Mature_130_residues
SIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAPVDQQVEVPIIEKHIGQILADK
GDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWEIMGRKKIVRVK

Specific function: Functions by promoting the formation of the first peptide bond

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-5A family

Homologues:

Organism=Homo sapiens, GI9966867, Length=78, Percent_Identity=35.8974358974359, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI219555712, Length=69, Percent_Identity=40.5797101449275, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI219555710, Length=69, Percent_Identity=40.5797101449275, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4503545, Length=69, Percent_Identity=40.5797101449275, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI219555707, Length=69, Percent_Identity=40.5797101449275, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI153791632, Length=78, Percent_Identity=35.8974358974359, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17534327, Length=105, Percent_Identity=35.2380952380952, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71990399, Length=105, Percent_Identity=34.2857142857143, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320801, Length=91, Percent_Identity=36.2637362637363, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322507, Length=91, Percent_Identity=35.1648351648352, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF5A_SULTO (Q971T0)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377231.1
- ProteinModelPortal:   Q971T0
- SMR:   Q971T0
- GeneID:   1459298
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1296
- NMPDR:   fig|273063.1.peg.1399
- HOGENOM:   HBG497107
- OMA:   CRIVEMS
- ProtClustDB:   PRK03999
- BioCyc:   STOK273063:ST1296-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00085
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR019769
- InterPro:   IPR001884
- InterPro:   IPR022847
- InterPro:   IPR020189
- InterPro:   IPR013185
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PANTHER:   PTHR11673
- PIRSF:   PIRSF003025
- TIGRFAMs:   TIGR00037

Pfam domain/function: PF08207 EFP_N; PF01287 eIF-5a; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 14561; Mature: 14430

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00302 IF5A_HYPUSINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAP
CEEEEEEECCEEECCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEECC
VDQQVEVPIIEKHIGQILADKGDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWE
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCHHHHCCCCCCEEEEE
IMGRKKIVRVK
ECCCEEEEEEC
>Mature Secondary Structure 
SIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAP
EEEEEEECCEEECCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEECC
VDQQVEVPIIEKHIGQILADKGDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWE
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCHHHHCCCCCCEEEEE
IMGRKKIVRVK
ECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479