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The map label for this gene is purM [H]

Identifier: 59712535

GI number: 59712535

Start: 2157140

End: 2158180

Strand: Direct

Name: purM [H]

Synonym: VF_1928

Alternate gene names: 59712535

Gene position: 2157140-2158180 (Clockwise)

Preceding gene: 59712533

Following gene: 59712536

Centisome position: 74.45

GC content: 42.84

Gene sequence:

>1041_bases
GTGAGCGACAACAAAACTTCTCTTAGCTACAAAGATGCTGGCGTAGACATTGATGCTGGTAATGCACTTGTTGATCGAAT
TAAAGGCGTAGTAAAACGCACTCGTCGTCCAGAAGTAATGGGCGGCATTGGTGGTTTTGGTGCGTTATGTGAACTTCCGA
CGAAATACAAGCAACCACTTTTAGTTTCTGGTACTGATGGCGTAGGTACAAAACTTCGTCTAGCACTCGATTTAAATAAG
CACGATACCATTGGTATTGACTTAGTTGCTATGTGTGTAAATGACCTAATTGTTCAAGGTGCTGAGCCACTTTTCTTCCT
TGATTACTATGCAACAGGCAAACTTGATGTTGATGTTGCTGCTGAAGTAGTTACAGGCATTGGTGAAGGCTGTATTCAAG
CCGGTTGTGCATTGATTGGTGGTGAAACCGCTGAAATGCCAGGTATGTATGAAGGCGAAGATTACGATGTTGCTGGCTTC
TGTGTTGGTGTTGTAGAAAAAGAAGACGTTATTGACGGAACTAAAGTTGCCGCTGGTGACGCTCTTATCGCTGTAGGTTC
AAGTGGCCCACACTCAAACGGTTACTCATTAATTCGTAAGATCCTTGAAGTATCAAACGCTGATCTTAACGAAGAGTTAA
ATGGAAAAACTATTGCTGCTCACCTAATTGAACCAACGAAAATCTATATTAAATCAGCGCTTAAGATGATTGCTGAGCAT
GATATTCATGCTATCTCACACATCACTGGCGGTGGTTTCTGGGAAAATATTCCACGCGTTTTACCACAAGGCACAAAAGC
TGTCGTAGATGGTAGCAGTTGGGAATGGCCTGCTATTTTCAACTGGTTACAAGAAAAAGGTAACGTTGATACCTACGAAA
TGTACCGCACTTTCAACTGTGGTGTAGGTCTTGTTGTTGCACTTCCAAAAGAGCAAGCTGAACAAGCGGTTGCTTTATTA
AATGCTGAAGGCGAAAACGCTTGGGTTATCGGCGAAATTGCAGCAGCAGAGCAAGGCGAAGAACAAGTAGAGATCCGTTA
A

Upstream 100 bases:

>100_bases
AAAATTATGCAAAATTCCTTACGCAAACGTTTCCCTTTTTACATTGTGCTGTTAGAATGGCGCGGATTTTTGAAATCCAA
CCTATGGCGAGGACACCTCC

Downstream 100 bases:

>100_bases
TCGTTCTTTAAACTTTGACTTAGTTCATAAAGAAAAAATAAAAGGTGATCATTTAATCGATCACCTTTTTTATAGCTATT
ATTTATGTTCGAATAGTTCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSDNKTSLSYKDAGVDIDAGNALVDRIKGVVKRTRRPEVMGGIGGFGALCELPTKYKQPLLVSGTDGVGTKLRLALDLNK
HDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAEVVTGIGEGCIQAGCALIGGETAEMPGMYEGEDYDVAGF
CVGVVEKEDVIDGTKVAAGDALIAVGSSGPHSNGYSLIRKILEVSNADLNEELNGKTIAAHLIEPTKIYIKSALKMIAEH
DIHAISHITGGGFWENIPRVLPQGTKAVVDGSSWEWPAIFNWLQEKGNVDTYEMYRTFNCGVGLVVALPKEQAEQAVALL
NAEGENAWVIGEIAAAEQGEEQVEIR

Sequences:

>Translated_346_residues
MSDNKTSLSYKDAGVDIDAGNALVDRIKGVVKRTRRPEVMGGIGGFGALCELPTKYKQPLLVSGTDGVGTKLRLALDLNK
HDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAEVVTGIGEGCIQAGCALIGGETAEMPGMYEGEDYDVAGF
CVGVVEKEDVIDGTKVAAGDALIAVGSSGPHSNGYSLIRKILEVSNADLNEELNGKTIAAHLIEPTKIYIKSALKMIAEH
DIHAISHITGGGFWENIPRVLPQGTKAVVDGSSWEWPAIFNWLQEKGNVDTYEMYRTFNCGVGLVVALPKEQAEQAVALL
NAEGENAWVIGEIAAAEQGEEQVEIR
>Mature_345_residues
SDNKTSLSYKDAGVDIDAGNALVDRIKGVVKRTRRPEVMGGIGGFGALCELPTKYKQPLLVSGTDGVGTKLRLALDLNKH
DTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAEVVTGIGEGCIQAGCALIGGETAEMPGMYEGEDYDVAGFC
VGVVEKEDVIDGTKVAAGDALIAVGSSGPHSNGYSLIRKILEVSNADLNEELNGKTIAAHLIEPTKIYIKSALKMIAEHD
IHAISHITGGGFWENIPRVLPQGTKAVVDGSSWEWPAIFNWLQEKGNVDTYEMYRTFNCGVGLVVALPKEQAEQAVALLN
AEGENAWVIGEIAAAEQGEEQVEIR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=48.5549132947977, Blast_Score=337, Evalue=9e-93,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=48.5549132947977, Blast_Score=337, Evalue=9e-93,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=48.5549132947977, Blast_Score=337, Evalue=9e-93,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=73.7609329446064, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=41.9825072886297, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=48.2248520710059, Blast_Score=317, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24582400, Length=292, Percent_Identity=41.0958904109589, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36880; Mature: 36749

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKTSLSYKDAGVDIDAGNALVDRIKGVVKRTRRPEVMGGIGGFGALCELPTKYKQPL
CCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCHHHCCCE
LVSGTDGVGTKLRLALDLNKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVA
EEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHH
AEVVTGIGEGCIQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEDVIDGTKVAAGD
HHHHHHCCHHHHHHCHHEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCC
ALIAVGSSGPHSNGYSLIRKILEVSNADLNEELNGKTIAAHLIEPTKIYIKSALKMIAEH
EEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
DIHAISHITGGGFWENIPRVLPQGTKAVVDGSSWEWPAIFNWLQEKGNVDTYEMYRTFNC
HHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHEEEECC
GVGLVVALPKEQAEQAVALLNAEGENAWVIGEIAAAEQGEEQVEIR
CCEEEEECCHHHHHHHHHHEECCCCCEEEEEEEHHCCCCCCCCCCC
>Mature Secondary Structure 
SDNKTSLSYKDAGVDIDAGNALVDRIKGVVKRTRRPEVMGGIGGFGALCELPTKYKQPL
CCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCHHHCCCE
LVSGTDGVGTKLRLALDLNKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVA
EEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHH
AEVVTGIGEGCIQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEDVIDGTKVAAGD
HHHHHHCCHHHHHHCHHEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCC
ALIAVGSSGPHSNGYSLIRKILEVSNADLNEELNGKTIAAHLIEPTKIYIKSALKMIAEH
EEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
DIHAISHITGGGFWENIPRVLPQGTKAVVDGSSWEWPAIFNWLQEKGNVDTYEMYRTFNC
HHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHEEEECC
GVGLVVALPKEQAEQAVALLNAEGENAWVIGEIAAAEQGEEQVEIR
CCEEEEECCHHHHHHHHHHEECCCCCEEEEEEEHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA