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The map label for this gene is gcvR [H]

Identifier: 59712526

GI number: 59712526

Start: 2148568

End: 2149095

Strand: Direct

Name: gcvR [H]

Synonym: VF_1919

Alternate gene names: 59712526

Gene position: 2148568-2149095 (Clockwise)

Preceding gene: 59712523

Following gene: 59712527

Centisome position: 74.15

GC content: 35.61

Gene sequence:

>528_bases
ATGTCTCAATACCTTGTAATTACTGCGGTCGGCACAGACAGACCGGGTATATCGAATAAGGTGACTCGCCTTGTCACTGA
GTCAAGCTGCAATATAGTAGATAGCCGTATCGCCTCATTTGGTAATGAGTTCACATTAATCATGTTGTTGTCAGGTACAG
CAAACGCTATCTCTCGAATTGAAAATACATTACCACTATTAGGTCAACAGCATGATCTAATTACCATGATGAAACGTACT
TCACCTCATCAAGAAAAAGACATTTTCTATACCATTGACGCATTTATTGAATCAGAAGACCGTCCAGGATTGACTGAAAA
ATTTACCGATTTTCTTGCTAATCGAGATATCGATTTGAAAACACTCAGTGCTCAAACATTAAAAAAATCAGAAAATCAAA
ATACATTTCAGATCCAAATTACGGCCGAAATATTTAAAGAGTGCCATATCATTGAGATTCAAGAAGAGTTTGAATCCTTA
TGCGCTTCATTAAATGTCAGTGGTAAAATCAATTTCTATAAAAATTAA

Upstream 100 bases:

>100_bases
TTGTAGAGTCTTTTTTTTGACGATTGTTCACTATTGCTTGCTTATCACACAATCACTTGCGTGTTAGTATGTAGATATCT
TTTTCAACAACGAGTTTTTT

Downstream 100 bases:

>100_bases
AGGCAAATAGACCTAATACCATTCAGGATAAATAGTTGAACAAGCAAGAATGAGCAACTAACTATGTGGATTGGTATAAA
CCCATAAAAGGAAAGAGAAT

Product: DNA-binding transcriptional repressor, regulatory protein accessory to GcvA

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSQYLVITAVGTDRPGISNKVTRLVTESSCNIVDSRIASFGNEFTLIMLLSGTANAISRIENTLPLLGQQHDLITMMKRT
SPHQEKDIFYTIDAFIESEDRPGLTEKFTDFLANRDIDLKTLSAQTLKKSENQNTFQIQITAEIFKECHIIEIQEEFESL
CASLNVSGKINFYKN

Sequences:

>Translated_175_residues
MSQYLVITAVGTDRPGISNKVTRLVTESSCNIVDSRIASFGNEFTLIMLLSGTANAISRIENTLPLLGQQHDLITMMKRT
SPHQEKDIFYTIDAFIESEDRPGLTEKFTDFLANRDIDLKTLSAQTLKKSENQNTFQIQITAEIFKECHIIEIQEEFESL
CASLNVSGKINFYKN
>Mature_174_residues
SQYLVITAVGTDRPGISNKVTRLVTESSCNIVDSRIASFGNEFTLIMLLSGTANAISRIENTLPLLGQQHDLITMMKRTS
PHQEKDIFYTIDAFIESEDRPGLTEKFTDFLANRDIDLKTLSAQTLKKSENQNTFQIQITAEIFKECHIIEIQEEFESLC
ASLNVSGKINFYKN

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=171, Percent_Identity=43.2748538011696, Blast_Score=139, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 19759; Mature: 19628

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYLVITAVGTDRPGISNKVTRLVTESSCNIVDSRIASFGNEFTLIMLLSGTANAISRI
CCCEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ENTLPLLGQQHDLITMMKRTSPHQEKDIFYTIDAFIESEDRPGLTEKFTDFLANRDIDLK
HHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
TLSAQTLKKSENQNTFQIQITAEIFKECHIIEIQEEFESLCASLNVSGKINFYKN
EHHHHHHHHCCCCCEEEEEEEHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SQYLVITAVGTDRPGISNKVTRLVTESSCNIVDSRIASFGNEFTLIMLLSGTANAISRI
CCEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ENTLPLLGQQHDLITMMKRTSPHQEKDIFYTIDAFIESEDRPGLTEKFTDFLANRDIDLK
HHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEE
TLSAQTLKKSENQNTFQIQITAEIFKECHIIEIQEEFESLCASLNVSGKINFYKN
EHHHHHHHHCCCCCEEEEEEEHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]