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The map label for this gene is pepD [H]

Identifier: 59711343

GI number: 59711343

Start: 801736

End: 803190

Strand: Reverse

Name: pepD [H]

Synonym: VF_0736

Alternate gene names: 59711343

Gene position: 803190-801736 (Counterclockwise)

Preceding gene: 59711349

Following gene: 59711330

Centisome position: 27.72

GC content: 40.76

Gene sequence:

>1455_bases
GTGTCTGAGATCAGTCAACTAACCCCTCAACCTCTTTGGCAATTTTTTGACAAAATCTGTTCTATTCCTCACCCTTCAAA
ACATGAAGAAGCATTGGCCCAATACATTATTGAATGGGCAACAACTGAAGGTCTAGATGTGCGCCGTGATCCTACTGGTA
ACGTTTTTATTAAAAAGCCAGCAACACCAGGCATGGAAGATCGCAAAGGCGTAGTTCTACAAGCTCATATCGATATGGTT
CCACAAAAAAATGAAGATACAGAGCACGACTTCACTAAAGATCCAATTCAACCATACATTGATGGTGAGTGGGTAACGGC
AAAAGGAACTACGCTTGGTGCTGATAACGGCATGGGTATGGCATCTTGTCTTGCAGTGTTAGCATCAAAAGAGCTAAAAC
ACGGCCCTCTAGAAGTATTATTAACTATCGATGAAGAAGCAGGTATGACAGGAGCTTTTGGTCTGGAAGCTGGATGGTTA
GAAGGTGATATCCTTTTAAACACAGATTCAGAGCAAGAAGGCGAAGTTTACATGGGTTGTGCTGGTGGTGCCGATGGTGC
TATCAAATTAGACATTGAACGTGAAGCCCTTCCTTCTGGTTACATCACTCGACAAATCACACTAAAAGGCTTAAAAGGTG
GTCATTCAGGTTGTGATATTCATACTGGCCGTGGGAACGCAAACAAACTACTAGGTCGTTTTTTAGCTGGTCACGCACAA
GAGCTTGATTTACGCCTTGTTGAATTCCGTGGCGGTAGTCTACGTAATGCAATTCCACGTGAAGCTTTTGCTACTATTGC
AGTTCCTGCCGAAAATGAAGCTAAGTTAGCCGAATTATTTACTTTCTATACAAACCTATTAAAAGATGAATTAGGCAAAG
TAGAAACAGATATCGTTAGCTTTAACGAAACAGCATCTGCAGAACAAGTACTAACAAAGATCACTCAATCTCGTTTTATT
GCGACACTAAATGCATGTCCAAACGGTGTAATTCGCATGAGCGATGATATCGAAGGTGTAGTTGAGACATCATTAAATGT
TGGTGTGATCACTACTGACGAAAATAGCATTACTATTCTATGTCTTATCCGCTCATTAATGGATTCAGGCCGTAGCATGG
TTGAAGGTATGCTTTCATCTGTCGCTGAGCTAGCTGGCGCTCAAGTCACTTTCTCAGGCACTTACCCTGGTTGGAAGCCT
GATGCAGATTCAGAAATAATGCACGTTTTCCGTGATGTATATGAAGGTATCTACGGCAATAAACCAAATATCATGGTAAT
TCATGCAGGTCTTGAGTGTGGATTATTTAAGAAACCTTATCCAGAAATGGATATGATTTCATTTGGCCCAACTATCAAGT
TCCCTCACTCTCCTGATGAGAAAGTGAAAATTGATACTGTTGCTTTATACTGGGAACAAATGGTGGCTATTTTAGAAAAT
ATTCCTAAAAAATAA

Upstream 100 bases:

>100_bases
ATTCGCTAGATTCAGAGGTATACTGAATTGTATTAACAAACAATGACTCAAATAATTAGAGCATTAATAAGTAAAAACCG
TTTTCATAAAGGAGATTCTT

Downstream 100 bases:

>100_bases
TGCTATCTAACTAAATAATAAACGGTCAGCACATGCTGACCGTTTTTTATTTACGCAATTATAATTTAAATAAGTACCTA
ATTATTCTTACTTAAATTGG

Product: aminoacyl-histidine dipeptidase (peptidase D)

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSEISQLTPQPLWQFFDKICSIPHPSKHEEALAQYIIEWATTEGLDVRRDPTGNVFIKKPATPGMEDRKGVVLQAHIDMV
PQKNEDTEHDFTKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWL
EGDILLNTDSEQEGEVYMGCAGGADGAIKLDIEREALPSGYITRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAQ
ELDLRLVEFRGGSLRNAIPREAFATIAVPAENEAKLAELFTFYTNLLKDELGKVETDIVSFNETASAEQVLTKITQSRFI
ATLNACPNGVIRMSDDIEGVVETSLNVGVITTDENSITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVTFSGTYPGWKP
DADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKKPYPEMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
IPKK

Sequences:

>Translated_484_residues
MSEISQLTPQPLWQFFDKICSIPHPSKHEEALAQYIIEWATTEGLDVRRDPTGNVFIKKPATPGMEDRKGVVLQAHIDMV
PQKNEDTEHDFTKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWL
EGDILLNTDSEQEGEVYMGCAGGADGAIKLDIEREALPSGYITRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAQ
ELDLRLVEFRGGSLRNAIPREAFATIAVPAENEAKLAELFTFYTNLLKDELGKVETDIVSFNETASAEQVLTKITQSRFI
ATLNACPNGVIRMSDDIEGVVETSLNVGVITTDENSITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVTFSGTYPGWKP
DADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKKPYPEMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
IPKK
>Mature_483_residues
SEISQLTPQPLWQFFDKICSIPHPSKHEEALAQYIIEWATTEGLDVRRDPTGNVFIKKPATPGMEDRKGVVLQAHIDMVP
QKNEDTEHDFTKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLE
GDILLNTDSEQEGEVYMGCAGGADGAIKLDIEREALPSGYITRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAQE
LDLRLVEFRGGSLRNAIPREAFATIAVPAENEAKLAELFTFYTNLLKDELGKVETDIVSFNETASAEQVLTKITQSRFIA
TLNACPNGVIRMSDDIEGVVETSLNVGVITTDENSITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVTFSGTYPGWKPD
ADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKKPYPEMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILENI
PKK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=63.0927835051546, Blast_Score=647, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52893; Mature: 52762

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEISQLTPQPLWQFFDKICSIPHPSKHEEALAQYIIEWATTEGLDVRRDPTGNVFIKKP
CCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECC
ATPGMEDRKGVVLQAHIDMVPQKNEDTEHDFTKDPIQPYIDGEWVTAKGTTLGADNGMGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCH
ASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEVYMGC
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEE
AGGADGAIKLDIEREALPSGYITRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAQ
CCCCCCEEEEEEEHHCCCCCCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCH
ELDLRLVEFRGGSLRNAIPREAFATIAVPAENEAKLAELFTFYTNLLKDELGKVETDIVS
HCCEEEEEECCCCHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHEE
FNETASAEQVLTKITQSRFIATLNACPNGVIRMSDDIEGVVETSLNVGVITTDENSITIL
CCCCCCHHHHHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHCCCCEEEEEECCCCEEHH
CLIRSLMDSGRSMVEGMLSSVAELAGAQVTFSGTYPGWKPDADSEIMHVFRDVYEGIYGN
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
KPNIMVIHAGLECGLFKKPYPEMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
CCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IPKK
CCCC
>Mature Secondary Structure 
SEISQLTPQPLWQFFDKICSIPHPSKHEEALAQYIIEWATTEGLDVRRDPTGNVFIKKP
CCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECC
ATPGMEDRKGVVLQAHIDMVPQKNEDTEHDFTKDPIQPYIDGEWVTAKGTTLGADNGMGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCH
ASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEVYMGC
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEE
AGGADGAIKLDIEREALPSGYITRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAQ
CCCCCCEEEEEEEHHCCCCCCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHCCCH
ELDLRLVEFRGGSLRNAIPREAFATIAVPAENEAKLAELFTFYTNLLKDELGKVETDIVS
HCCEEEEEECCCCHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHEE
FNETASAEQVLTKITQSRFIATLNACPNGVIRMSDDIEGVVETSLNVGVITTDENSITIL
CCCCCCHHHHHHHHHHHHHEEECCCCCCCEEEECCCHHHHHHCCCCEEEEEECCCCEEHH
CLIRSLMDSGRSMVEGMLSSVAELAGAQVTFSGTYPGWKPDADSEIMHVFRDVYEGIYGN
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
KPNIMVIHAGLECGLFKKPYPEMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
CCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IPKK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]