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The map label for this gene is phoP [H]

Identifier: 59711133

GI number: 59711133

Start: 561383

End: 562063

Strand: Reverse

Name: phoP [H]

Synonym: VF_0526

Alternate gene names: 59711133

Gene position: 562063-561383 (Counterclockwise)

Preceding gene: 59711134

Following gene: 59711132

Centisome position: 19.4

GC content: 35.54

Gene sequence:

>681_bases
ATGCAAATAGCTCTTGTTGAAGATAATGAAATCTTAAACCACCACCTGTCTAGTCAATTAAAAGATCAGGGACACGTTGT
TTATTCTGATAAAACAGCCTCTGCATTTTTACAAACCGTACAAAAAAAAGAACACATTGATGTCATGATTGTTGATTTAG
GTCTACCTGATTTCGACGGTATCACTCTCATCAAGCAAATTCGCCGCAAAGAAATTCATAGCCCTATTCTCATACTTACC
GCTCGTGGAAACTGGCAAGATAAAGTTGAAGGACTTGAGGCTGGAGCTGACGACTACCTAGTAAAACCTTTCCAATCTGA
AGAATTAATAGCAAGGCTTTATGCTCTAGCAAGACGAGCAGCCGGATTTACACAATCAAAAGTAACCGCTGAAAATATTG
AATTAGACATAAAAGCAAAAACCATCCATGTAGACGGTCAATTTCTACAATTAACTTCATTTGAATATGATATCGCTGCT
TATTTAATAAAAAACAGCTTAAAAATCATATCAAAGCAACAATTTGTTGATGCTTTATATCAAGAAGATTCTGAAGTTCA
ACTCAATAATATTGAAGTTATCATTTCACGTTTAAGAAAGAAATTTGCAGCCGTTGGTCATAATGAACTGATTACAACGG
TACGAGGTCAGGGCTATCAGTTTCAAATAAAGGCGAAGTAA

Upstream 100 bases:

>100_bases
AATTTAATAAAGCCCATCAATTCATGGGCTTTATTATTTAAAAACAAAATGATAAGTGTTATTAATGACGATATAAACCT
AAGGAATCAATCGGTATATT

Downstream 100 bases:

>100_bases
TCATGAAGCGTTTAGTTCAAAACCAATTTCGACGACGCATATTATTCAGTTTTTTAGCTGTCGTTATTGGTTTTTTAATA
CTAAACGGTTACCTTCGCTA

Product: DNA-binding response regulator in two-component regulatory system with PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MQIALVEDNEILNHHLSSQLKDQGHVVYSDKTASAFLQTVQKKEHIDVMIVDLGLPDFDGITLIKQIRRKEIHSPILILT
ARGNWQDKVEGLEAGADDYLVKPFQSEELIARLYALARRAAGFTQSKVTAENIELDIKAKTIHVDGQFLQLTSFEYDIAA
YLIKNSLKIISKQQFVDALYQEDSEVQLNNIEVIISRLRKKFAAVGHNELITTVRGQGYQFQIKAK

Sequences:

>Translated_226_residues
MQIALVEDNEILNHHLSSQLKDQGHVVYSDKTASAFLQTVQKKEHIDVMIVDLGLPDFDGITLIKQIRRKEIHSPILILT
ARGNWQDKVEGLEAGADDYLVKPFQSEELIARLYALARRAAGFTQSKVTAENIELDIKAKTIHVDGQFLQLTSFEYDIAA
YLIKNSLKIISKQQFVDALYQEDSEVQLNNIEVIISRLRKKFAAVGHNELITTVRGQGYQFQIKAK
>Mature_226_residues
MQIALVEDNEILNHHLSSQLKDQGHVVYSDKTASAFLQTVQKKEHIDVMIVDLGLPDFDGITLIKQIRRKEIHSPILILT
ARGNWQDKVEGLEAGADDYLVKPFQSEELIARLYALARRAAGFTQSKVTAENIELDIKAKTIHVDGQFLQLTSFEYDIAA
YLIKNSLKIISKQQFVDALYQEDSEVQLNNIEVIISRLRKKFAAVGHNELITTVRGQGYQFQIKAK

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=44, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.6515837104072, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=34.9557522123894, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=29.9559471365639, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=30.6666666666667, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.2869955156951, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=30.6666666666667, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=30.4932735426009, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.0884955752212, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=29.8245614035088, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=29.1304347826087, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788394, Length=237, Percent_Identity=29.535864978903, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI2367329, Length=175, Percent_Identity=32, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=28.3582089552239, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25620; Mature: 25620

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIALVEDNEILNHHLSSQLKDQGHVVYSDKTASAFLQTVQKKEHIDVMIVDLGLPDFDG
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
ITLIKQIRRKEIHSPILILTARGNWQDKVEGLEAGADDYLVKPFQSEELIARLYALARRA
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
AGFTQSKVTAENIELDIKAKTIHVDGQFLQLTSFEYDIAAYLIKNSLKIISKQQFVDALY
CCCCCCCEEHHHEEEEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEDSEVQLNNIEVIISRLRKKFAAVGHNELITTVRGQGYQFQIKAK
CCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MQIALVEDNEILNHHLSSQLKDQGHVVYSDKTASAFLQTVQKKEHIDVMIVDLGLPDFDG
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
ITLIKQIRRKEIHSPILILTARGNWQDKVEGLEAGADDYLVKPFQSEELIARLYALARRA
HHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
AGFTQSKVTAENIELDIKAKTIHVDGQFLQLTSFEYDIAAYLIKNSLKIISKQQFVDALY
CCCCCCCEEHHHEEEEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEDSEVQLNNIEVIISRLRKKFAAVGHNELITTVRGQGYQFQIKAK
CCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA