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The map label for this gene is phoQ1 [H]

Identifier: 59711132

GI number: 59711132

Start: 560037

End: 561380

Strand: Reverse

Name: phoQ1 [H]

Synonym: VF_0525

Alternate gene names: 59711132

Gene position: 561380-560037 (Counterclockwise)

Preceding gene: 59711133

Following gene: 59711131

Centisome position: 19.37

GC content: 35.49

Gene sequence:

>1344_bases
ATGAAGCGTTTAGTTCAAAACCAATTTCGACGACGCATATTATTCAGTTTTTTAGCTGTCGTTATTGGTTTTTTAATACT
AAACGGTTACCTTCGCTATCAGACAGCACGCTCTGACTTAATCACTGAATACACCCTTGATATCACTTATCAATTCCCAT
CTATTTTCAATGAAATGGTATCATCAAATTATATTATGCCATTACAAGAAGGGAATAAATCTCAGTATTACAGTTCATCG
TCTGATGATATAACAATTGTTATCTGTGACAATAATGACAATTTGTTATGGGATAGCATGCAAAAAGGTCCACCTTCCCA
TGTAGAGAACATCTGTACTGATTTACCTAAAGATGAAAACAAACCTATTCTCATTGAAAAACCAAGTGGTGCAGCCTTTA
TCTCTCATTCAATGAGTATTGAAAGTAATAATGACCTTCCGCCTAGGCGAGTAATATTACTCAGTCGTATGGAAGATAAA
ATATCTCGCCTACACACACTAAAGCTCCAATTAGCTATTGCTTATACAACTCTTATTTTAATTGCCATTTTTGGGGTGCT
ATGGGGATACAAGCGTTCATTTTTCCCCTTAAATAAGCTTCATATTGAATTAAAGAGTATAAAGGATAGTGAGCAAGAGA
AACTTATTTATAGCTATCCTGAAGAGCTAGAGCCTATTGCCAAAACAATTAACCGATTACTTGAACAACAAGATGAACAA
TCAAGTAAATACAAAAAAGCAATGGACGATTTAGCACATAGTCTTAAGACTCGAATAGCGACTTGTGATGCATTGTTATA
TCAAAAAGAACCGCCTATTGCAGATATCATGGAACAACTCAATGATATGGACTCTGTGATACAACACCAATTGAAACGTG
CGTTGATGGGCTCTAGGGGCATAAGTAAGCATCACACTTTACTCTCTCCTATTGTAGATAAACTCACTAAAATGTTTACT
AAGGTTCATAAAGAGCGTCATATCGAATTCATTCCTAACTATAATGACGCGCAAACCTTACCTATTAATTACAATGACTT
AATGGAAATTCTCGGAAATATCTTAGAGAACAGTTATCGCTTTGCTGATAACTATATTATTTTATCTATTGTAGAGCGTA
GTGAAGGCTTCAATATTCATATTGAAAATGATGGCGAGCCTTTACCTCAAGATAAAATTGAATCGGTATTTCAACGAGGA
ATTCGCGCAGATGAAAAGAACCCTGGCACGGGGATTGGACTTGCGGTATGTGAAGAGATCATATCCAGTTATAACGGGCA
AATCTGGTTCCATACACAAGATACCGGCTCAAGATTAGAAATATTTTTACCACATCAAATATAA

Upstream 100 bases:

>100_bases
TTTCACGTTTAAGAAAGAAATTTGCAGCCGTTGGTCATAATGAACTGATTACAACGGTACGAGGTCAGGGCTATCAGTTT
CAAATAAAGGCGAAGTAATC

Downstream 100 bases:

>100_bases
GTAATAATGACAAATCTAAATAATAATTATGGATTTTATCGGATCTTTTTTTCTTTAATCCTAGGAATTCTGCTCTTTAG
TACTCCAATTTTGTTTCTAA

Product: sensory histidine kinase in two-compoent regulatory system with PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKRLVQNQFRRRILFSFLAVVIGFLILNGYLRYQTARSDLITEYTLDITYQFPSIFNEMVSSNYIMPLQEGNKSQYYSSS
SDDITIVICDNNDNLLWDSMQKGPPSHVENICTDLPKDENKPILIEKPSGAAFISHSMSIESNNDLPPRRVILLSRMEDK
ISRLHTLKLQLAIAYTTLILIAIFGVLWGYKRSFFPLNKLHIELKSIKDSEQEKLIYSYPEELEPIAKTINRLLEQQDEQ
SSKYKKAMDDLAHSLKTRIATCDALLYQKEPPIADIMEQLNDMDSVIQHQLKRALMGSRGISKHHTLLSPIVDKLTKMFT
KVHKERHIEFIPNYNDAQTLPINYNDLMEILGNILENSYRFADNYIILSIVERSEGFNIHIENDGEPLPQDKIESVFQRG
IRADEKNPGTGIGLAVCEEIISSYNGQIWFHTQDTGSRLEIFLPHQI

Sequences:

>Translated_447_residues
MKRLVQNQFRRRILFSFLAVVIGFLILNGYLRYQTARSDLITEYTLDITYQFPSIFNEMVSSNYIMPLQEGNKSQYYSSS
SDDITIVICDNNDNLLWDSMQKGPPSHVENICTDLPKDENKPILIEKPSGAAFISHSMSIESNNDLPPRRVILLSRMEDK
ISRLHTLKLQLAIAYTTLILIAIFGVLWGYKRSFFPLNKLHIELKSIKDSEQEKLIYSYPEELEPIAKTINRLLEQQDEQ
SSKYKKAMDDLAHSLKTRIATCDALLYQKEPPIADIMEQLNDMDSVIQHQLKRALMGSRGISKHHTLLSPIVDKLTKMFT
KVHKERHIEFIPNYNDAQTLPINYNDLMEILGNILENSYRFADNYIILSIVERSEGFNIHIENDGEPLPQDKIESVFQRG
IRADEKNPGTGIGLAVCEEIISSYNGQIWFHTQDTGSRLEIFLPHQI
>Mature_447_residues
MKRLVQNQFRRRILFSFLAVVIGFLILNGYLRYQTARSDLITEYTLDITYQFPSIFNEMVSSNYIMPLQEGNKSQYYSSS
SDDITIVICDNNDNLLWDSMQKGPPSHVENICTDLPKDENKPILIEKPSGAAFISHSMSIESNNDLPPRRVILLSRMEDK
ISRLHTLKLQLAIAYTTLILIAIFGVLWGYKRSFFPLNKLHIELKSIKDSEQEKLIYSYPEELEPIAKTINRLLEQQDEQ
SSKYKKAMDDLAHSLKTRIATCDALLYQKEPPIADIMEQLNDMDSVIQHQLKRALMGSRGISKHHTLLSPIVDKLTKMFT
KVHKERHIEFIPNYNDAQTLPINYNDLMEILGNILENSYRFADNYIILSIVERSEGFNIHIENDGEPLPQDKIESVFQRG
IRADEKNPGTGIGLAVCEEIISSYNGQIWFHTQDTGSRLEIFLPHQI

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=277, Percent_Identity=28.8808664259928, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=22.8215767634855, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=24.8979591836735, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51502; Mature: 51502

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLVQNQFRRRILFSFLAVVIGFLILNGYLRYQTARSDLITEYTLDITYQFPSIFNEMV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHHHHHHHH
SSNYIMPLQEGNKSQYYSSSSDDITIVICDNNDNLLWDSMQKGPPSHVENICTDLPKDEN
HCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCC
KPILIEKPSGAAFISHSMSIESNNDLPPRRVILLSRMEDKISRLHTLKLQLAIAYTTLIL
CCEEEECCCCCEEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIFGVLWGYKRSFFPLNKLHIELKSIKDSEQEKLIYSYPEELEPIAKTINRLLEQQDEQ
HHHHHHHHHCCCCCCCHHHHHEEHHHCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHH
SSKYKKAMDDLAHSLKTRIATCDALLYQKEPPIADIMEQLNDMDSVIQHQLKRALMGSRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ISKHHTLLSPIVDKLTKMFTKVHKERHIEFIPNYNDAQTLPINYNDLMEILGNILENSYR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCHHHHHHHHHHHHHCCHH
FADNYIILSIVERSEGFNIHIENDGEPLPQDKIESVFQRGIRADEKNPGTGIGLAVCEEI
HCCCEEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ISSYNGQIWFHTQDTGSRLEIFLPHQI
HHHCCCEEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MKRLVQNQFRRRILFSFLAVVIGFLILNGYLRYQTARSDLITEYTLDITYQFPSIFNEMV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHHHHHHHH
SSNYIMPLQEGNKSQYYSSSSDDITIVICDNNDNLLWDSMQKGPPSHVENICTDLPKDEN
HCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCC
KPILIEKPSGAAFISHSMSIESNNDLPPRRVILLSRMEDKISRLHTLKLQLAIAYTTLIL
CCEEEECCCCCEEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIFGVLWGYKRSFFPLNKLHIELKSIKDSEQEKLIYSYPEELEPIAKTINRLLEQQDEQ
HHHHHHHHHCCCCCCCHHHHHEEHHHCCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHH
SSKYKKAMDDLAHSLKTRIATCDALLYQKEPPIADIMEQLNDMDSVIQHQLKRALMGSRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ISKHHTLLSPIVDKLTKMFTKVHKERHIEFIPNYNDAQTLPINYNDLMEILGNILENSYR
CCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCHHHHHHHHHHHHHCCHH
FADNYIILSIVERSEGFNIHIENDGEPLPQDKIESVFQRGIRADEKNPGTGIGLAVCEEI
HCCCEEEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ISSYNGQIWFHTQDTGSRLEIFLPHQI
HHHCCCEEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA