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The map label for this gene is norB [H]

Identifier: 57652259

GI number: 57652259

Start: 2508363

End: 2509763

Strand: Reverse

Name: norB [H]

Synonym: SACOL2449

Alternate gene names: 57652259

Gene position: 2509763-2508363 (Counterclockwise)

Preceding gene: 57652260

Following gene: 57652258

Centisome position: 89.33

GC content: 34.33

Gene sequence:

>1401_bases
ATGGACACATCAAAACAATTTAGAGGTGACAACCGATTGCTTTTGGGTATCGTTTTAGGGGTTATTACCTTTTGGCTATT
CGCGCAGTCACTTGTTAATCTTGTTGTCCCATTACAATCAACATATAGTAGTGACGTTGGAACGATAAATATCGCTGTTA
GCTTATCTGCCTTATTTGCTGGTTTGTTTATCGTAGGTGCTGGTGATGTTGCTGATAAATTTGGTCGCGTCAAAATTACT
TATGTAGGATTGATATTAAATGTTGTAGGTTCATTACTCATCATCATTACACCTTTGCCAGCATTTTTAATTATAGGTAG
AATAATTCAAGGTTTGTCTGCAGCATGTATTATGCCATCAACACTTGCTATTATTAACGAATATTATATTGGTACAAGAA
GACAACGTGCCTTAAGCTATTGGTCTATTGGTTCTTGGGGTGGTAGTGGTATTTGTACGTTGTTTGGTGGCTTAATGGCT
ACATATATAGGTTGGCGTTCAATATTTGTTGTTTCAATTCTATTAACATTATTAGCAATGTACTTAATCAAACATGCACC
TGAGACTAAAGCAGAACCAATCAAAGGTATGAAAGCAGAAGCTAAAAAGTTTGACGTTATTGGTTTAGTCATTTTAGTAG
TGACGATGTTAAGTTTAAATGTAATCATCACACAGACGTCTCATTTTGGTTTAGTTTCACCGTTAATTCTAGCTTTAATT
GTTGTGTTTATCTGTTCATTAGTTGGTTTTGTATATTACGAAAATAAAATAAAGCATCCACTTGTTGATTTTTCAATTTT
TAAAAATAGAGGATACAGTGGTGCAACTATTTCAAACTTCTTATTAAATGGTGTAGCAGGTGGTGCACTTATCGTTATTA
ACACGTATTATCAACAACAATTAGGATTTAATTCTTCGCAAACGGGTTATATTTCATTAACGTATTTAATAACAGTGTTG
TCAATGATTCGTGTAGGTGAAAAGATTTTATCTCAACATGGTCCGAAGCGCCCACTATTACTAGGAAGTGGCTTTACAGT
GATTGGGTTAATCTTATTGTCGTTAACATTTTTACCAGAAGTGTGGTATATCATATCTAGTATAGTTGGATATTTATTGT
TTGGTACTGGTTTAGGATTATATGCTACACCATCAACTGATACAGCAGTTGCTAGTGCGCCAGATGATAAGTCGGGTGTT
GCTTCAGGTGTGTATAAAATGGCGTCATCATTAGGAAATGCATTTGGAGTAGCAGTATCTGGTACGGTTTATACTGTGTT
AGCAGCTAATTTAAATTTGAACTTAGGTGGTTTCACAGGTATGATGTTTAATGCCTTGCTAGCAATTGTTGCATTTTTAG
TCATTTTACTATTAGTTCCTAAAAATCAAACGAATTTGTAA

Upstream 100 bases:

>100_bases
AGATGTTTTATTTATAATTTTCTGCAAATTTATGATATTGTTTCTTAATATATCATATTAAAAATTTGTTTTTCTTAAAC
ATAGGAGGCTTATCTAATTC

Downstream 100 bases:

>100_bases
AACTGAAATGAAAGCAAGTTATTATGTAGGGATTTTAAAGGAAATTTTGTGAAAGTAAGTTTATCATACACACTTAATGT
TGCGTATTGACGTTTAATGT

Product: drug transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILALI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLITVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL

Sequences:

>Translated_466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILALI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLITVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
>Mature_466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILALI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLITVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL

Specific function: Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=352, Percent_Identity=25, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788710, Length=333, Percent_Identity=23.7237237237237, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790195, Length=375, Percent_Identity=22.9333333333333, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=411, Percent_Identity=23.1143552311436, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49856; Mature: 49856

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
GLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPS
HHHHCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHH
TLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILALI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQ
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHH
LGFNSSQTGYISLTYLITVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
VWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVS
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCEEEC
GTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
GLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPS
HHHHCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHH
TLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILALI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQ
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHH
LGFNSSQTGYISLTYLITVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
VWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVS
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCEEEC
GTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA