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The map label for this gene is panE [C]

Identifier: 57652258

GI number: 57652258

Start: 2507202

End: 2508137

Strand: Reverse

Name: panE [C]

Synonym: SACOL2448

Alternate gene names: 57652258

Gene position: 2508137-2507202 (Counterclockwise)

Preceding gene: 57652259

Following gene: 57652257

Centisome position: 89.28

GC content: 35.58

Gene sequence:

>936_bases
ATGAAAATTGCAATTGCTGGATCGGGTGCATTAGGTAGTGGCTTTGGTGCCAAACTATTTCAAGCAGGATATGATGTCAC
ACTTATTGACGGATATACATCTCATGTTGAAGCGGTTAAGCAACATGGATTAAATATAACGATTAATGGAGAGGCATTCG
AGTTAAACATTCCGATGTATCATTTTAATGATCAACCGGACGAAAGCATTTACGATGTTGTCTTTCTATTTCCAAAGTCT
ATGCAATTAAAAGAAGTGATGGAAGATATGAAGCCACATATTGATAATGAAACGATCGTCGTATGTACGATGAATGGTCT
GAAGCATGAAGAAGTCATTGCGCAGTATGTTGCTCAATCACAAATTGTCAGAGGTGTTACGACTTGGACGGCAGGTCTTG
AAAGCCCTGGACACAGTCATTTACTTGGTAGTGGACCAGTTGAAATAGGTGAACTAGTGGATGAAGGTAAAGAAAATGTT
ATAAAAGTTGCTGATTTACTTAACGAAGCGGAATTGAATGGTGTCATTAGTAAAGATTTATACCAATCGATTTGGAAAAA
GATTTGTGTTAATGGTACGGCAAATGCATTAAGCACAGTGTTGGAGTGTAATATGGCATCGCTGAATGAAAGTAGTTATG
CGAAGTGTTTGATTTATAAATTAACGCAAGAAATAGTGCATGTAGCGACGATTGATAATGTTCATTTAAATGTTGATGAA
GTATTTGAATATTTAGTTGATTTAAATGAAAAAGTTGGTGCGCATTATCCATCCATGTATCAAGATTTAATTGTTAATAA
TAGAAAAACTGAAATTGATTATATTAATGGCGCAGTTGCAACATTAGGTAAACAACGTCATATTGAAGCGCCAGTCAATC
GCTTTATTACTGATTTAATTCATACTAAAGAAAGTCAGCGACACGCACAGGATTAA

Upstream 100 bases:

>100_bases
AAAGCTGTGTGCATATTAAGCGAATGATTTTCAAATTGACGCTAATATGCGAAAGTAGTATTTTTAAAATGAACAACAAC
GATGAAGAGGGGTTTATAGG

Downstream 100 bases:

>100_bases
TTGGTGTTTTAGGTATGATTACAAGGAAATGACAATCACGTGATATTACGGTCATTATTAAGATTGAAATGTAATAAATA
AAGAACAGCAGTAAGGTACT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMYHFNDQPDESIYDVVFLFPKS
MQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQSQIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENV
IKVADLLNEAELNGVISKDLYQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDE
VFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLIHTKESQRHAQD

Sequences:

>Translated_311_residues
MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMYHFNDQPDESIYDVVFLFPKS
MQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQSQIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENV
IKVADLLNEAELNGVISKDLYQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDE
VFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLIHTKESQRHAQD
>Mature_311_residues
MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMYHFNDQPDESIYDVVFLFPKS
MQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQSQIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENV
IKVADLLNEAELNGVISKDLYQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDE
VFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLIHTKESQRHAQD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=310, Percent_Identity=23.2258064516129, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34445; Mature: 34445

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMY
CEEEEECCCCCCCCCCHHHHHCCCCEEEECCCHHHHHHHHHCCCEEEECCCEEEEECCEE
HFNDQPDESIYDVVFLFPKSMQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQS
ECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
QIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENVIKVADLLNEAELNGVISKDL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
YQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDE
HHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHEECCEEECHHH
VFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLI
HHHHHHCCHHHHCCCCHHHHHHHHHCCCCCEEHHHCCHHHHHCCCCCCHHHHHHHHHHHH
HTKESQRHAQD
HHCHHHHCCCC
>Mature Secondary Structure
MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMY
CEEEEECCCCCCCCCCHHHHHCCCCEEEECCCHHHHHHHHHCCCEEEECCCEEEEECCEE
HFNDQPDESIYDVVFLFPKSMQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQS
ECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
QIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENVIKVADLLNEAELNGVISKDL
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
YQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDE
HHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHEECCEEECHHH
VFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLI
HHHHHHCCHHHHCCCCHHHHHHHHHCCCCCEEHHHCCHHHHHCCCCCCHHHHHHHHHHHH
HTKESQRHAQD
HHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]