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The map label for this gene is glmS

Identifier: 57652173

GI number: 57652173

Start: 2206327

End: 2208132

Strand: Reverse

Name: glmS

Synonym: SACOL2145

Alternate gene names: 57652173

Gene position: 2208132-2206327 (Counterclockwise)

Preceding gene: 57652178

Following gene: 57652172

Centisome position: 78.6

GC content: 35.11

Gene sequence:

>1806_bases
ATGTGTGGAATTGTTGGTTATATTGGCTATGATAATGCCAAAGAATTATTATTAAAAGGTTTAGAAAAATTAGAATACAG
AGGTTATGACTCTGCAGGTATCGCAGTAGTAAATGATGATAATACAACTGTATTTAAAGAAAAAGGTCGTATTGCAGAAT
TACGTAAAGTTGCTGATAGTAGCGATTTTGATGGACCTGTTGGAATCGGTCACACACGTTGGGCAACACACGGTGTACCG
AATCATGAAAACTCTCATCCACATCAATCATCAAATGGCCGTTTTACTCTAGTTCATAACGGTGTTATTGAAAACTATGA
AGAGTTAAAAGGTGAATACTTACAAGGTGTATCATTCATTTCAGAAACAGATACAGAAGTTATCGTTCAATTAGTTGAAT
ACTTTTCAAATCAAGGACTTTCAACTGAAGAAGCATTTACAAAAGTTGTGTCATTATTACATGGTTCATATGCATTAGGT
TTATTAGATGCTGAAGACAAAGACACAATCTATGTTGCTAAAAATAAATCACCATTATTATTAGGTGTTGGTGAAGGTTT
CAATGTTATCGCATCAGACGCACTTGCAATGTTACAAGTGACAAGCGAATATAAAGAAATCCATGACCATGAAATCGTTA
TTGTTAAAAAAGATGAAGTTATTATTAAAGATGCAGATGGAAACGTTGTAGAACGTGATTCATATATTGCTGAAATTGAT
GCATCAGATGCTGAAAAAGGTGTTTATGCACACTACATGTTAAAAGAAATTCATGAACAACCAGCAGTAATGCGTCGTAT
TATTCAAGAATATCAAGATGCAGAAGGTAACTTGAAAATTGATCAAGACATCATCAATGATGTTAAAGAAGCAGACCGCA
TTTACGTTATTGCAGCAGGTACAAGCTACCATGCAGGTTTAGTAGGTAAAGAATTTTTAGAAAAATGGGCTGGCGTACCA
ACTGAAGTACACGTTGCATCAGAGTTTGTCTACAACATGCCATTATTATCTGAAAAACCATTGTTCGTTTATATTTCTCA
ATCAGGTGAAACTGCAGATAGCCGCGCCGTATTAGTTGAAACTAATAAATTAGGTCATAAATCATTAACAATCACTAATG
TTGCAGGTTCAACTTTATCACGTGAAGCAGACCACACATTGTTATTACACGCGGGTCCTGAAATCGCAGTTGCATCTACA
AAAGCATATACTGCACAAATTGCAGTATTATCAATCTTGTCTCAAATCGTTGCAAAAGAGCATGGTCGTGAAGCAGATAT
TGATTTATTGAGAGAATTAGCAAAAGTAACAACAGCAATAGAAGCAATTGTTGACGATGCACCAATTATGGAACAAATTG
CTACAGATTTCTTAGAAACAACACGCAATGCATTCTTTATCGGACGTACTATTGACTATAACGTAAGTTTAGAAGGTGCG
TTAAAACTTAAAGAAATTTCTTACATTCAAGCAGAAGGTTTTGCTGGTGGAGAACTTAAACATGGTACAATTGCCTTAAT
CGAAGAAGGTACACCAGTTGTAGGTTTAGCAACACAAGAGAAAGTTAATTTATCAATTCGTGGTAACGTTAAAGAGGTAG
TAGCACGTGGTGCACATCCATGTATTATTTCTATGGAGGGTCTTGAAAAAGAAGGCGACACTTATGTCATTCCTCATGTA
CATGAATTGTTAACGCCATTAGTATCAGTGGTTGCATTACAATTAATTTCATACTATGCAGCATTACACAGAGATTTAGA
TGTTGATAAACCACGTAACCTTGCTAAATCAGTTACTGTGGAATAA

Upstream 100 bases:

>100_bases
CATGTTCCTATTTATATTATGAAAGCAGATTGTCAATCTAAATTATCGGCAATAAATCATAATTTACGCGTACTATTCCA
ATATGGAGGAAAATGTCGTT

Downstream 100 bases:

>100_bases
TTCACTTTTTTAGAATCAATCATGTATTAAAATTAAAGTATATGGCACCCTTTTAGATTAATCGACTAGAAGGGTGCTTT
TTTAGGTCGACTTAGCTTTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVP
NHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALG
LLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEID
ASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVP
TEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVAST
KAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGA
LKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHV
HELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE

Sequences:

>Translated_601_residues
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVP
NHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALG
LLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEID
ASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVP
TEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVAST
KAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGA
LKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHV
HELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>Mature_601_residues
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVP
NHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALG
LLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEID
ASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVP
TEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVAST
KAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGA
LKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHV
HELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=32.8467153284672, Blast_Score=334, Evalue=2e-91,
Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=33.2369942196532, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI29570798, Length=267, Percent_Identity=25.4681647940075, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=41.1092985318108, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1788651, Length=200, Percent_Identity=26, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=441, Percent_Identity=33.3333333333333, Blast_Score=217, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17532897, Length=441, Percent_Identity=33.3333333333333, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17539970, Length=437, Percent_Identity=34.0961098398169, Blast_Score=215, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=428, Percent_Identity=32.9439252336449, Blast_Score=227, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=376, Percent_Identity=27.9255319148936, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=35.609756097561, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=31.6473988439306, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI28573187, Length=269, Percent_Identity=27.5092936802974, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659598, Length=251, Percent_Identity=26.6932270916335, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659604, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_STAAC (Q5HE49)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186958.1
- ProteinModelPortal:   Q5HE49
- SMR:   Q5HE49
- STRING:   Q5HE49
- EnsemblBacteria:   EBSTAT00000010850
- GeneID:   3237437
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2145
- TIGR:   SACOL2145
- eggNOG:   COG0449
- GeneTree:   EBGT00050000023831
- HOGENOM:   HBG645312
- OMA:   QGAFAIA
- ProtClustDB:   PRK00331
- BioCyc:   SAUR93062:SACOL2145-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 65850; Mature: 65850

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 596-596

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADS
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHCC
SDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
SETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLL
HCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
LGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEID
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCEEECCCEEEEEC
ASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAG
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVE
CCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEE
TNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKE
ECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHH
HGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCC
LKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHP
EEEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEECCCHHHHHHCCCCC
CIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTV
EEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
E
C
>Mature Secondary Structure
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADS
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHCC
SDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHH
SETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLL
HCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
LGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEID
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCEEECCCEEEEEC
ASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAG
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVE
CCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEE
TNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKE
ECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHH
HGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCC
LKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHP
EEEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEECCCEEEEEECCCHHHHHHCCCCC
CIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTV
EEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA