BacMap

Definition	Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession	NC_002951
Length	2,809,422

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The map label for this gene is yvgN [H]

Identifier: 57652081

GI number: 57652081

Start: 1889489

End: 1890322

Strand: Reverse

Name: yvgN [H]

Synonym: SACOL1835

Alternate gene names: 57652081

Gene position: 1890322-1889489 (Counterclockwise)

Preceding gene: 57652082

Following gene: 57652078

Centisome position: 67.29

GC content: 34.53

Gene sequence:

>834_bases
ATGGAGGTTAAAACATTTTATAATGGAAACACGATGCCACAAATTGGTTTAGGGACATTTCGTGTGGAAAATGATGAAAA
TTGCATGGAAAGTGTTAAGTATGCCATTGAACAAGGATATCGTAGTATTGATACCGCAAAAGTTTATGGGAATGAAGAAC
AAGTAGGTGCTGGCATTCGTGCCGGATTGGAGTCAACTGGTATTGCTAGAGAAGACTTATTTATTACTTCAAAATTATAT
TTTGAGGATTTCGGTCGTGAAAATGTAGCAGCTGCTTACGAAGCTAGTTTATCTAGATTAGGTTTAAAATACTTAGATTT
GTATCTAGTACATTGGCCAGGTACGAACGAAGCCGTAATGGTTGATACATGGAAAGGTATGGAAGATTTATATAAAAATA
ATAATGTTAAAAATATAGGTGTCAGCAATTTTGAACCTGAACATTTGGAAGCTTTGTTGGCACAAGTGTCAATTAAACCT
GTAATTAATCAAGTTGAATATCATCCATATTTAACCCAACATAAATTGAAATTATATTTGGCAGCACAACGTATCGTGAT
GGAATCTTGGTCACCATTGATGAATGCACAAATTTTAAATGATGAGACAATTAAAGACATTGCTCAAGAATTAGGAAAGT
CACCTGCCCAAGTTGTTTTAAGATGGAATGTGCAGCATGCTGTGGTTACAATCCCTAAATCGGTGACACCAAACAGAATC
TCTGAAAATTTCCAAATATTTGATTTCGAATTATCAGATGAACAAATGACGCGAATTGATGGTTTAAATCAAGATAAGAG
AATTGGACCTGATCCAAAAAAATTTGAAGGCTAG

Upstream 100 bases:

>100_bases
ATTTTAGTGGTTGATTGCTCTAAGTGTTTTTTCTCATGTATTCAACTCAGATTTGTTATGATAACAGGGTATAATACATC
AAAAAGGTGAGGCGATATTT

Downstream 100 bases:

>100_bases
ATTAAAATCGCTCAACTGATGAAAAGGTTAGATGAATTGTCAGGGCTTGGGACATTAAGTTCTTAGGCGATGTAAAAAAG
CTGATTTCTATTAATTATTT

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG

Sequences:

>Translated_277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG
>Mature_277_residues
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLY
FEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVMVDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKP
VINQVEYHPYLTQHKLKLYLAAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI223468663, Length=286, Percent_Identity=42.3076923076923, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=38.4868421052632, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=36.426116838488, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=36.426116838488, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI291291012, Length=268, Percent_Identity=40.2985074626866, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI5174695, Length=295, Percent_Identity=37.2881355932203, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI45446745, Length=293, Percent_Identity=37.2013651877133, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI4503285, Length=293, Percent_Identity=37.2013651877133, Blast_Score=184, Evalue=6e-47,
Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=40.893470790378, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI310109920, Length=293, Percent_Identity=36.8600682593857, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI5453543, Length=293, Percent_Identity=36.518771331058, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI24497585, Length=293, Percent_Identity=37.542662116041, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=38.1818181818182, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=36.0824742268041, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI300116273, Length=273, Percent_Identity=36.2637362637363, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=35.5072463768116, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI207028673, Length=121, Percent_Identity=43.801652892562, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI310109926, Length=121, Percent_Identity=42.9752066115703, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=36.3636363636364, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI87082198, Length=277, Percent_Identity=44.4043321299639, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=32.6923076923077, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=30.2816901408451, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17537077, Length=290, Percent_Identity=36.8965517241379, Blast_Score=186, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=39.3258426966292, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17564128, Length=294, Percent_Identity=33.6734693877551, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17538386, Length=269, Percent_Identity=36.0594795539033, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17537075, Length=296, Percent_Identity=36.1486486486487, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17552492, Length=279, Percent_Identity=32.258064516129, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=33.5640138408304, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17561298, Length=269, Percent_Identity=33.457249070632, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=34.1911764705882, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=32.4232081911263, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=31.8840579710145, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=29.8657718120805, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=296, Percent_Identity=37.1621621621622, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=35.7142857142857, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320576, Length=291, Percent_Identity=35.7388316151203, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=31.7307692307692, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319625, Length=272, Percent_Identity=33.4558823529412, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=32.5088339222615, Blast_Score=138, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=39.4463667820069, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24663317, Length=290, Percent_Identity=38.6206896551724, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21356425, Length=290, Percent_Identity=38.2758620689655, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=37.3333333333333, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24662789, Length=292, Percent_Identity=36.986301369863, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24662785, Length=292, Percent_Identity=43.8356164383562, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129731, Length=285, Percent_Identity=37.1929824561403, Blast_Score=180, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24662781, Length=294, Percent_Identity=43.5374149659864, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=35, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=33.1010452961672, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=32.421875, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31472; Mature: 31472

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR
CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHEECCCHHHHCCHHH
AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM
CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE
VDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL
EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI
HHHHHHHHHCCHHHCEEECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHH
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG
CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIR
CCEEEEECCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCCCCCHHEECCCHHHHCCHHH
AGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAVM
CCCHHCCCCHHHEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEE
VDTWKGMEDLYKNNNVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYL
EECCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AAQRIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHAVVTIPKSVTPNRI
HHHHHHHHHCCHHHCEEECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCHH
SENFQIFDFELSDEQMTRIDGLNQDKRIGPDPKKFEG
CCCCEEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]