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The map label for this gene is accC [H]

Identifier: 57651997

GI number: 57651997

Start: 1689999

End: 1691360

Strand: Reverse

Name: accC [H]

Synonym: SACOL1661

Alternate gene names: 57651997

Gene position: 1691360-1689999 (Counterclockwise)

Preceding gene: 57651998

Following gene: 57651996

Centisome position: 60.2

GC content: 35.68

Gene sequence:

>1362_bases
ATGCTTCGTTGTTTAATTGCGAACAGAGGTGAAATTGCTGTAAGGATTATAAGAGCTTGCAGAGAATATGGGATTGAAAC
TGTAGCAGTTTATGCAAAAGGGGACGAGCAAAGCTTGCATGTACATTTAGCAGATCAAGCTATATGTATTGGGGAAGCTA
ATGCTTTAGATAGTTATTTAAATATTGACCGCATCATATCTGCTGCACAAATCACTGGTGCTAATGCAATTCACCCAGGA
TATGGCTTTTTATCAGAATCAACAAAATTTGCTCAAACCGTTGAGGAACAAGGCATAGCGTTTATAGGGCCTACTAAAAA
AACGATGGAAATGATGGGGGATAAAATAACAGCAAGACAAACAGTTCATCATGCAGGTGTTCCTGTGATTCCAGGATCAA
ATGGTGCTGTGAATCATGTGTCTGAAATTGAGAATCTTGCCAAAGACATCGGTTATCCAGTTGTTATCAAAGCTGCCAGT
GGCGGTGGTGGTAAAGGTATACGTATTGTAAAGAAAGCTGAAGATTTAGAAAAGGCATTTAAAGAAGCTAAAAGTGAAGG
AAAAAAATACTTTGATGATGATCGTGTTTATGTTGAGGCTTTTATACCTGTTGCAAAACATGTTGAAGTTCAAGTTATGG
GAGATGGGCAGGATAATTATGTACATTTAGGGGAACGTGATTGTTCTGTACAACGTAAAAATCAAAAATTAATCGAAGAA
TCTCCTTGTGCAGCATTAACTGAAGAAAGACGACAACAAATATGTAACGATGCTGTTAAAGTTGCACGTGCAGCAAATTA
TAGAAGTGCAGGTACGATTGAATTTTTAGTAACTGATACCGCACATTACTTTATTGAAATGAATGCTCGAATACAAGTTG
AACATACTGTTACAGAGATGCGAGCAGAACGTGATTTGGTTGCAGCACAACTGTATTTATTGGAACATAATCATTTACCT
TTTTCACAAAGCGATATTCAATTTAATGGTCATGTGATAGAAGCGAGAATAAATGCCGAAAATCCTGAAAAGAAATTTCA
ACCAACACCAGGTAAAGTGACAGCGTTACATTTACCTCAAGGCTTTAATGTGCGAGTCGATTCTTTACTATATCACGGTT
ATCAAGTTTCACCATATTATGATTCTTTAGTAGCTAAAGTAATTGTAAAATCTCATGATAGAGCTTCAGCAATTGATAAG
TTGAAAGTCACCTTAGATGAAATGGTGATAGATGGATTTTCTACAACTGCCGATTTTTTATATGCAGTTTTAAATTATCC
ACTATATCGTGATGGAGATGCAAAAGATGTTGATATTAAATTTTTAGAAAAACATCAAATTGTTAAAGGGGTGGAATTAT
AA

Upstream 100 bases:

>100_bases
ACAGATGTTGCTGGAGAAATTACTGAAATAGTAGCTGATCATGGCACAAATGTTGAATACGACCAAGTTTTGGTACGTAT
TAAGTAAAGGGGGTAAGTAA

Downstream 100 bases:

>100_bases
TGCGAGTTGATTTGAATTGTGATTTAGGCGAAGCATTTGGAAATTATTCCTTTGGTGGTGATCATCAAATTATTCCGTTA
ATTACAAGTGCGAATGTTGC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MLRCLIANRGEIAVRIIRACREYGIETVAVYAKGDEQSLHVHLADQAICIGEANALDSYLNIDRIISAAQITGANAIHPG
YGFLSESTKFAQTVEEQGIAFIGPTKKTMEMMGDKITARQTVHHAGVPVIPGSNGAVNHVSEIENLAKDIGYPVVIKAAS
GGGGKGIRIVKKAEDLEKAFKEAKSEGKKYFDDDRVYVEAFIPVAKHVEVQVMGDGQDNYVHLGERDCSVQRKNQKLIEE
SPCAALTEERRQQICNDAVKVARAANYRSAGTIEFLVTDTAHYFIEMNARIQVEHTVTEMRAERDLVAAQLYLLEHNHLP
FSQSDIQFNGHVIEARINAENPEKKFQPTPGKVTALHLPQGFNVRVDSLLYHGYQVSPYYDSLVAKVIVKSHDRASAIDK
LKVTLDEMVIDGFSTTADFLYAVLNYPLYRDGDAKDVDIKFLEKHQIVKGVEL

Sequences:

>Translated_453_residues
MLRCLIANRGEIAVRIIRACREYGIETVAVYAKGDEQSLHVHLADQAICIGEANALDSYLNIDRIISAAQITGANAIHPG
YGFLSESTKFAQTVEEQGIAFIGPTKKTMEMMGDKITARQTVHHAGVPVIPGSNGAVNHVSEIENLAKDIGYPVVIKAAS
GGGGKGIRIVKKAEDLEKAFKEAKSEGKKYFDDDRVYVEAFIPVAKHVEVQVMGDGQDNYVHLGERDCSVQRKNQKLIEE
SPCAALTEERRQQICNDAVKVARAANYRSAGTIEFLVTDTAHYFIEMNARIQVEHTVTEMRAERDLVAAQLYLLEHNHLP
FSQSDIQFNGHVIEARINAENPEKKFQPTPGKVTALHLPQGFNVRVDSLLYHGYQVSPYYDSLVAKVIVKSHDRASAIDK
LKVTLDEMVIDGFSTTADFLYAVLNYPLYRDGDAKDVDIKFLEKHQIVKGVEL
>Mature_453_residues
MLRCLIANRGEIAVRIIRACREYGIETVAVYAKGDEQSLHVHLADQAICIGEANALDSYLNIDRIISAAQITGANAIHPG
YGFLSESTKFAQTVEEQGIAFIGPTKKTMEMMGDKITARQTVHHAGVPVIPGSNGAVNHVSEIENLAKDIGYPVVIKAAS
GGGGKGIRIVKKAEDLEKAFKEAKSEGKKYFDDDRVYVEAFIPVAKHVEVQVMGDGQDNYVHLGERDCSVQRKNQKLIEE
SPCAALTEERRQQICNDAVKVARAANYRSAGTIEFLVTDTAHYFIEMNARIQVEHTVTEMRAERDLVAAQLYLLEHNHLP
FSQSDIQFNGHVIEARINAENPEKKFQPTPGKVTALHLPQGFNVRVDSLLYHGYQVSPYYDSLVAKVIVKSHDRASAIDK
LKVTLDEMVIDGFSTTADFLYAVLNYPLYRDGDAKDVDIKFLEKHQIVKGVEL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=448, Percent_Identity=42.8571428571429, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=41.4253897550111, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=41.4253897550111, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=41.4253897550111, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=42.8251121076233, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=42.8251121076233, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=42.8251121076233, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI38679977, Length=483, Percent_Identity=31.4699792960663, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679967, Length=483, Percent_Identity=31.4699792960663, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=483, Percent_Identity=31.4699792960663, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679960, Length=483, Percent_Identity=31.4699792960663, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=483, Percent_Identity=31.4699792960663, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=30, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=47.4040632054176, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=43.7219730941704, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=43.652561247216, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17567343, Length=434, Percent_Identity=42.6267281105991, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.038854805726, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=489, Percent_Identity=28.0163599182004, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=489, Percent_Identity=28.0163599182004, Blast_Score=197, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=423, Percent_Identity=42.3167848699764, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=438, Percent_Identity=42.6940639269406, Blast_Score=316, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6319695, Length=438, Percent_Identity=41.324200913242, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6324343, Length=498, Percent_Identity=30.1204819277108, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323863, Length=488, Percent_Identity=29.0983606557377, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651757, Length=431, Percent_Identity=43.3874709976798, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=42.7293064876958, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24651759, Length=395, Percent_Identity=42.2784810126582, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=29.7786720321932, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=29.7786720321932, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=29.7786720321932, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=29.7786720321932, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50225; Mature: 50225

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRCLIANRGEIAVRIIRACREYGIETVAVYAKGDEQSLHVHLADQAICIGEANALDSYL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEEECCHHHHHHH
NIDRIISAAQITGANAIHPGYGFLSESTKFAQTVEEQGIAFIGPTKKTMEMMGDKITARQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHHH
TVHHAGVPVIPGSNGAVNHVSEIENLAKDIGYPVVIKAASGGGGKGIRIVKKAEDLEKAF
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHHHH
KEAKSEGKKYFDDDRVYVEAFIPVAKHVEVQVMGDGQDNYVHLGERDCSVQRKNQKLIEE
HHHHHCCCCCCCCCCEEEEEECCHHHCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHC
SPCAALTEERRQQICNDAVKVARAANYRSAGTIEFLVTDTAHYFIEMNARIQVEHTVTEM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEEEHHHHHH
RAERDLVAAQLYLLEHNHLPFSQSDIQFNGHVIEARINAENPEKKFQPTPGKVTALHLPQ
HHHHHHHHHEEEEEECCCCCCCCCCEEECCEEEEEEECCCCCHHCCCCCCCCEEEEECCC
GFNVRVDSLLYHGYQVSPYYDSLVAKVIVKSHDRASAIDKLKVTLDEMVIDGFSTTADFL
CCCEEEHHHEECCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
YAVLNYPLYRDGDAKDVDIKFLEKHQIVKGVEL
HHHHCCCEECCCCCCCCCCEEHHHHHHHCCCCC
>Mature Secondary Structure
MLRCLIANRGEIAVRIIRACREYGIETVAVYAKGDEQSLHVHLADQAICIGEANALDSYL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEEECCHHHHHHH
NIDRIISAAQITGANAIHPGYGFLSESTKFAQTVEEQGIAFIGPTKKTMEMMGDKITARQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHHH
TVHHAGVPVIPGSNGAVNHVSEIENLAKDIGYPVVIKAASGGGGKGIRIVKKAEDLEKAF
HHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHHHH
KEAKSEGKKYFDDDRVYVEAFIPVAKHVEVQVMGDGQDNYVHLGERDCSVQRKNQKLIEE
HHHHHCCCCCCCCCCEEEEEECCHHHCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHC
SPCAALTEERRQQICNDAVKVARAANYRSAGTIEFLVTDTAHYFIEMNARIQVEHTVTEM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEEEHHHHHH
RAERDLVAAQLYLLEHNHLPFSQSDIQFNGHVIEARINAENPEKKFQPTPGKVTALHLPQ
HHHHHHHHHEEEEEECCCCCCCCCCEEECCEEEEEEECCCCCHHCCCCCCCCEEEEECCC
GFNVRVDSLLYHGYQVSPYYDSLVAKVIVKSHDRASAIDKLKVTLDEMVIDGFSTTADFL
CCCEEEHHHEECCEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
YAVLNYPLYRDGDAKDVDIKFLEKHQIVKGVEL
HHHHCCCEECCCCCCCCCCEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]