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The map label for this gene is glpK [H]

Identifier: 57651869

GI number: 57651869

Start: 1337055

End: 1338551

Strand: Direct

Name: glpK [H]

Synonym: SACOL1320

Alternate gene names: 57651869

Gene position: 1337055-1338551 (Clockwise)

Preceding gene: 57651868

Following gene: 57651870

Centisome position: 47.59

GC content: 36.61

Gene sequence:

>1497_bases
ATGGAAAAATATATTTTATCTATAGACCAAGGAACAACAAGCTCAAGAGCGATTTTATTCAATCAAAAAGGGGAAATTGC
AGGGGTAGCACAACGTGAGTTTAAGCAATATTTTCCACAATCAGGTTGGGTTGAACATGATGCAAATGAAATTTGGACAT
CTGTGTTAGCTGTAATGACGGAAGTAATTAATGAAAATGATGTTAGAGCTGATCAAATTGCAGGTATCGGTATTACAAAC
CAACGTGAAACAACGGTTGTTTGGGACAAACATACTGGCCGCCCAATTTATCACGCAATTGTTTGGCAATCACGTCAAAC
ACAATCAATTTGTTCAGAATTAAAACAACAAGGATATGAACAAACATTTAGAGATAAGACAGGATTACTTTTAGATCCGT
ATTTTGCAGGTACAAAAGTTAAATGGATTCTAGACAATGTTGAAGGTGCACGAGAAAAAGCAGAAAATGGCGATCTATTA
TTTGGAACGATTGATACTTGGTTAGTATGGAAATTATCAGGAAAAGCTGCGCATATTACTGATTATTCAAATGCGAGTCG
TACATTAATGTTTAATATCCATGATTTAGAATGGGACGATGAGTTATTAGAACTACTTACAGTACCTAAAAATATGTTGC
CAGAAGTTAAAGCTTCGAGTGAAGTATATGGTAAGACAATTGATTACCACTTCTATGGTCAAGAAGTACCAATCGCTGGA
GTAGCTGGTGATCAACAAGCAGCATTATTTGGACAAGCTTGCTTCGAACGTGGTGACGTGAAAAACACATATGGAACTGG
TGGCTTCATGTTAATGAATACAGGTGACAAAGCGGTTAAATCTGAAAGTGGTTTATTAACAACAATTGCTTATGGTATTG
ATGGAAAAGTAAATTATGCGCTTGAAGGTTCCATCTTTGTTTCGGGTTCAGCAATCCAATGGTTACGTGATGGATTAAGA
ATGATTAATTCAGCACCACAATCAGAAAGTTATGCGACACGAGTTGACTCTACTGAGGGTGTTTATGTTGTTCCAGCTTT
TGTAGGTTTAGGAACACCATATTGGGATTCTGAAGCACGTGGTGCGATTTTCGGTTTAACACGTGGAACTGAAAAAGAGC
ACTTTATCCGTGCAACTTTAGAATCACTATGTTACCAAACTCGTGACGTTATGGAAGCAATGTCAAAAGACTCTGGTATT
GATGTCCAAAGTTTACGTGTCGATGGTGGTGCAGTTAAAAATAACTTTATTATGCAGTTCCAAGCAGACATTGTTAATAC
TTCTGTTGAAAGACCTGAAATTCAAGAAACTACAGCTTTAGGTGCTGCATTTTTAGCAGGTTTAGCAGTTGGATTCTGGG
AGAGTAAAGATGATATCGCTAAAAACTGGAAATTAGAAGAAAAATTCGATCCGAAAATGGATGAAGGCGAAAGAGAAAAA
TTATATAGAGGTTGGAAAAAAGCTGTTGAAGCAACACAAGTTTTTAAAACAGAATAA

Upstream 100 bases:

>100_bases
TAACATGTTTGATTCATGGATTATGCTATTTTTTCGCCAAAATTTAACAGATTTTGTACAATGGGTTAGCGATTATTTTT
TAATAAAGGAGATACTACTA

Downstream 100 bases:

>100_bases
ACTTGTAGATTAGACTTTTGTATAAACATTGTGATACAATCAATTTAAGTTAATATTTGAATCGAGAAGCGAGAGATTTG
TTCGAACATGTACAATTGAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQSGWVEHDANEIWTSVLAVMTEVINENDVRADQIAGIGITN
QRETTVVWDKHTGRPIYHAIVWQSRQTQSICSELKQQGYEQTFRDKTGLLLDPYFAGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGKAAHITDYSNASRTLMFNIHDLEWDDELLELLTVPKNMLPEVKASSEVYGKTIDYHFYGQEVPIAG
VAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYALEGSIFVSGSAIQWLRDGLR
MINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEARGAIFGLTRGTEKEHFIRATLESLCYQTRDVMEAMSKDSGI
DVQSLRVDGGAVKNNFIMQFQADIVNTSVERPEIQETTALGAAFLAGLAVGFWESKDDIAKNWKLEEKFDPKMDEGEREK
LYRGWKKAVEATQVFKTE

Sequences:

>Translated_498_residues
MEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQSGWVEHDANEIWTSVLAVMTEVINENDVRADQIAGIGITN
QRETTVVWDKHTGRPIYHAIVWQSRQTQSICSELKQQGYEQTFRDKTGLLLDPYFAGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGKAAHITDYSNASRTLMFNIHDLEWDDELLELLTVPKNMLPEVKASSEVYGKTIDYHFYGQEVPIAG
VAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYALEGSIFVSGSAIQWLRDGLR
MINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEARGAIFGLTRGTEKEHFIRATLESLCYQTRDVMEAMSKDSGI
DVQSLRVDGGAVKNNFIMQFQADIVNTSVERPEIQETTALGAAFLAGLAVGFWESKDDIAKNWKLEEKFDPKMDEGEREK
LYRGWKKAVEATQVFKTE
>Mature_498_residues
MEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQSGWVEHDANEIWTSVLAVMTEVINENDVRADQIAGIGITN
QRETTVVWDKHTGRPIYHAIVWQSRQTQSICSELKQQGYEQTFRDKTGLLLDPYFAGTKVKWILDNVEGAREKAENGDLL
FGTIDTWLVWKLSGKAAHITDYSNASRTLMFNIHDLEWDDELLELLTVPKNMLPEVKASSEVYGKTIDYHFYGQEVPIAG
VAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYALEGSIFVSGSAIQWLRDGLR
MINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEARGAIFGLTRGTEKEHFIRATLESLCYQTRDVMEAMSKDSGI
DVQSLRVDGGAVKNNFIMQFQADIVNTSVERPEIQETTALGAAFLAGLAVGFWESKDDIAKNWKLEEKFDPKMDEGEREK
LYRGWKKAVEATQVFKTE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=503, Percent_Identity=46.1232604373757, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI4504007, Length=503, Percent_Identity=46.1232604373757, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI42794763, Length=507, Percent_Identity=45.7593688362919, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI41393575, Length=496, Percent_Identity=44.9596774193548, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI88196792, Length=505, Percent_Identity=32.8712871287129, Blast_Score=322, Evalue=7e-88,
Organism=Escherichia coli, GI1790361, Length=489, Percent_Identity=62.1676891615542, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=519, Percent_Identity=23.121387283237, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789987, Length=477, Percent_Identity=24.1090146750524, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1787789, Length=508, Percent_Identity=23.6220472440945, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789168, Length=470, Percent_Identity=21.4893617021277, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=497, Percent_Identity=40.8450704225352, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=26.7961165048544, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71986147, Length=294, Percent_Identity=31.9727891156463, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6321755, Length=545, Percent_Identity=34.3119266055046, Blast_Score=306, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17864214, Length=502, Percent_Identity=42.2310756972112, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24654573, Length=433, Percent_Identity=44.1108545034642, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24655555, Length=493, Percent_Identity=38.9452332657201, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655560, Length=493, Percent_Identity=38.9452332657201, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655570, Length=493, Percent_Identity=38.9452332657201, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655574, Length=493, Percent_Identity=38.9452332657201, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655565, Length=493, Percent_Identity=38.9452332657201, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19922058, Length=522, Percent_Identity=30.0766283524904, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=30.4703476482618, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24656367, Length=495, Percent_Identity=28.0808080808081, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI21357867, Length=510, Percent_Identity=27.2549019607843, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24656372, Length=330, Percent_Identity=30.9090909090909, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=27.2413793103448, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55626; Mature: 55626

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQSGWVEHDANEIWTSVLAVMT
CCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EVINENDVRADQIAGIGITNQRETTVVWDKHTGRPIYHAIVWQSRQTQSICSELKQQGYE
HHHCCCCCCHHHEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCHH
QTFRDKTGLLLDPYFAGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGKAAHIT
HHHHCCCCCEECCCCCCCEEEEEEECCHHHHHHCCCCCEEEEECCEEEEEEECCCEEEEE
DYSNASRTLMFNIHDLEWDDELLELLTVPKNMLPEVKASSEVYGKTIDYHFYGQEVPIAG
CCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCCCCCHHCCCEEEEEEECCCCCEEE
VAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYA
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCEEEEE
LEGSIFVSGSAIQWLRDGLRMINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEAR
EECEEEECCCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCEEEEEEHHHCCCCCCCCCCC
GAIFGLTRGTEKEHFIRATLESLCYQTRDVMEAMSKDSGIDVQSLRVDGGAVKNNFIMQF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEE
QADIVNTSVERPEIQETTALGAAFLAGLAVGFWESKDDIAKNWKLEEKFDPKMDEGEREK
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
LYRGWKKAVEATQVFKTE
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQSGWVEHDANEIWTSVLAVMT
CCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EVINENDVRADQIAGIGITNQRETTVVWDKHTGRPIYHAIVWQSRQTQSICSELKQQGYE
HHHCCCCCCHHHEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCHH
QTFRDKTGLLLDPYFAGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGKAAHIT
HHHHCCCCCEECCCCCCCEEEEEEECCHHHHHHCCCCCEEEEECCEEEEEEECCCEEEEE
DYSNASRTLMFNIHDLEWDDELLELLTVPKNMLPEVKASSEVYGKTIDYHFYGQEVPIAG
CCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCCCCCHHCCCEEEEEEECCCCCEEE
VAGDQQAALFGQACFERGDVKNTYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYA
CCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCEEEEE
LEGSIFVSGSAIQWLRDGLRMINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEAR
EECEEEECCCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCEEEEEEHHHCCCCCCCCCCC
GAIFGLTRGTEKEHFIRATLESLCYQTRDVMEAMSKDSGIDVQSLRVDGGAVKNNFIMQF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEE
QADIVNTSVERPEIQETTALGAAFLAGLAVGFWESKDDIAKNWKLEEKFDPKMDEGEREK
EHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
LYRGWKKAVEATQVFKTE
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA