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The map label for this gene is isdB [H]

Identifier: 57651738

GI number: 57651738

Start: 1145889

End: 1147826

Strand: Reverse

Name: isdB [H]

Synonym: SACOL1138

Alternate gene names: 57651738

Gene position: 1147826-1145889 (Counterclockwise)

Preceding gene: 57651739

Following gene: 57651735

Centisome position: 40.86

GC content: 32.61

Gene sequence:

>1938_bases
ATGAACAAACAGCAAAAAGAATTTAAATCATTTTATTCAATTAGAAAGTCATCACTAGGCGTTGCATCTGTAGCAATTAG
TACACTTTTATTATTAATGTCAAATGGCGAAGCACAAGCAGCAGCTGAAGAAACAGGTGGTACAAATACAGAAGCACAAC
CAAAAACTGAAGCAGTTGCAAGTCCAACAACAACATCTGAAAAAGCTCCAGAAACTAAACCAGTAGCTAATGCTGTCTCA
GTATCTAATAAAGAAGTTGAGGCCCCTACTTCTGAAACAAAAGAAGCTAAAGAAGTTAAAGAAGTTAAAGCCCCTAAGGA
AACAAAAGAAGTTAAACCAGCAGCAAAAGCCACTAACAATACATATCCTATTTTGAATCAGGAACTTAGAGAAGCGATTA
AAAACCCTGCAATAAAAGACAAAGATCATAGCGCACCAAACTCTCGTCCAATTGATTTTGAAATGAAAAAGAAAGATGGA
ACTCAACAGTTTTATCATTATGCAAGTTCTGTTAAACCTGCTAGAGTTATTTTCACTGATTCAAAACCAGAAATTGAATT
AGGATTACAATCAGGTCAATTTTGGAGAAAATTTGAAGTTTATGAAGGTGACAAAAAGTTGCCAATTAAATTAGTATCAT
ACGATACTGTTAAAGATTATGCTTACATTCGCTTCTCTGTATCAAACGGAACAAAAGCTGTTAAAATTGTTAGTTCAACA
CACTTCAATAACAAAGAAGAAAAATACGATTACACATTAATGGAATTCGCACAACCAATTTATAACAGTGCAGATAAATT
CAAAACTGAAGAAGATTATAAAGCTGAAAAATTATTAGCGCCATATAAAAAAGCGAAAACACTAGAAAGACAAGTTTATG
AATTAAATAAAATTCAAGATAAACTTCCTGAAAAATTAAAGGCTGAGTACAAGAAGAAATTAGAGGATACAAAGAAAGCT
TTAGATGAGCAAGTGAAATCAGCTATTACTGAATTCCAAAATGTACAACCAACAAATGAAAAAATGACTGATTTACAAGA
TACAAAATATGTTGTTTATGAAAGTGTTGAGAATAACGAATCTATGATGGATACTTTTGTTAAACACCCTATTAAAACAG
GTATGCTTAACGGCAAAAAATATATGGTCATGGAAACTACTAATGACGATTACTGGAAAGATTTCATGGTTGAAGGTCAA
CGTGTTAGAACTATAAGCAAAGATGCTAAAAATAATACTAGAACAATTATTTTCCCATATGTTGAAGGTAAAACTCTATA
TGATGCTATCGTTAAAGTTCACGTAAAAACGATTGATTATGATGGACAATACCATGTCAGAATCGTTGATAAAGAAGCAT
TTACAAAAGCCAATACCGATAAATCTAACAAAAAAGAACAACAAGATAACTCAGCTAAGAAGGAAGCTACTCCAGCTACG
CCTAGCAAACCAACACCATCACCTGTTGAAAAAGAATCACAAAAACAAGACAGCCAAAAAGATGACAATAAACAATTACC
AAGTGTTGAAAAAGAAAATGACGCATCTAGTGAGTCAGGTAAAGACAAAACGCCTGCTACAAAACCAACTAAAGGTGAAG
TAGAATCAAGTAGTACAACTCCAACTAAGGTAGTATCTACGACTCAAAATGTTGCAAAACCAACAACTGCTTCATCAAAA
ACAACAAAAGATGTTGTTCAAACTTCAGCAGGTTCTAGCGAAGCAAAAGATAGTGCTCCATTACAAAAAGCAAACATTAA
AAACACAAATGATGGACACACTCAAAGCCAAAACAATAAAAATACACAAGAAAATAAAGCAAAATCATTACCACAAACTG
GTGAAGAATCAAATAAAGATATGACATTACCATTAATGGCATTATTAGCTTTAAGTAGCATCGTTGCATTCGTATTACCT
AGAAAACGTAAAAACTAA

Upstream 100 bases:

>100_bases
AATAACGTTGCAATTAACTAACATTTCAATGTACAATACAAGTAATCAATTGATAATGATTATCAGTTGATAATATACAA
TTAGGAGTTGTTTCTACAAC

Downstream 100 bases:

>100_bases
TAAATCGTCTTTATATTTAATTATTAAATTAACAAATTTTAATTGGCGGATGAGGTATCCAGTTACCTCGTTCGCCAATT
ATTTTTCGCAATATAAAAAG

Product: LPXTG cell wall surface anchor protein

Products: NA

Alternate protein names: Fur-regulated protein B; Staphylococcal iron-regulated protein H; Staphylococcus aureus surface protein J [H]

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVS
VSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDG
TQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKA
LDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQ
RVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSK
TTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLP
RKRKN

Sequences:

>Translated_645_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVS
VSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDG
TQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKA
LDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQ
RVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSK
TTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLP
RKRKN
>Mature_645_residues
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVASPTTTSEKAPETKPVANAVS
VSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNNTYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDG
TQQFYHYASSVKPARVIFTDSKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQDKLPEKLKAEYKKKLEDTKKA
LDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQ
RVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTTPTKVVSTTQNVAKPTTASSK
TTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNKNTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLP
RKRKN

Specific function: Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also requ

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 NEAT domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR019948
- InterPro:   IPR019929
- InterPro:   IPR019931
- InterPro:   IPR006635
- InterPro:   IPR001899 [H]

Pfam domain/function: PF00746 Gram_pos_anchor; PF05031 NEAT; PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 72193; Mature: 72193

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50847 GRAM_POS_ANCHORING ; PS50978 NEAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHCC
SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHCCC
TYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTD
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEC
SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
CCCCEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECC
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD
CCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCH
SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY
HHHHHHHHCCHHHCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEE
VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
CCCCHHHHHHHHEEEEEEECCCEEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTT
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNK
CHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNKQQKEFKSFYSIRKSSLGVASVAISTLLLLMSNGEAQAAAEETGGTNTEAQPKTEAVA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHCC
SPTTTSEKAPETKPVANAVSVSNKEVEAPTSETKEAKEVKEVKAPKETKEVKPAAKATNN
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHCCC
TYPILNQELREAIKNPAIKDKDHSAPNSRPIDFEMKKKDGTQQFYHYASSVKPARVIFTD
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEC
SKPEIELGLQSGQFWRKFEVYEGDKKLPIKLVSYDTVKDYAYIRFSVSNGTKAVKIVSST
CCCCEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEEECC
HFNNKEEKYDYTLMEFAQPIYNSADKFKTEEDYKAEKLLAPYKKAKTLERQVYELNKIQD
CCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLPEKLKAEYKKKLEDTKKALDEQVKSAITEFQNVQPTNEKMTDLQDTKYVVYESVENNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCH
SMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPY
HHHHHHHHCCHHHCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEE
VEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKANTDKSNKKEQQDNSAKKEATPAT
CCCCHHHHHHHHEEEEEEECCCEEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
PSKPTPSPVEKESQKQDSQKDDNKQLPSVEKENDASSESGKDKTPATKPTKGEVESSSTT
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PTKVVSTTQNVAKPTTASSKTTKDVVQTSAGSSEAKDSAPLQKANIKNTNDGHTQSQNNK
CHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NTQENKAKSLPQTGEESNKDMTLPLMALLALSSIVAFVLPRKRKN
CCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA