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The map label for this gene is nanA [H]

Identifier: 57651239

GI number: 57651239

Start: 347117

End: 347998

Strand: Reverse

Name: nanA [H]

Synonym: SACOL0312

Alternate gene names: 57651239

Gene position: 347998-347117 (Counterclockwise)

Preceding gene: 57651241

Following gene: 57651238

Centisome position: 12.39

GC content: 35.03

Gene sequence:

>882_bases
ATGAACAAAGATTTAAAAGGTTTATATGCAGCGTTACTCGTTCCTTTTGATGAAAATGGTCAAGTAAATGAACAAGGACT
TAAACAAATTGCTCAAAATGCCATTGAAACTGAAGAATTAGACGGTCTTTATGTAAATGGTAGCTCAGGCGAAAACTTTT
TATTAAATACAGAGCAGAAGAAGCAAGTTTTCAAGGTTGCCAAAGAGGCAGTTGGGGATAAAGTGAAATTGATTGCTCAA
GTAGGTTCGTTAGATTTAAATGAAGCCATTGAACTTGGAAAATATGCCACAGAACTCGGTTATGATGCACTTTCTGCCGT
AACACCATTCTACTATCCATTTACTTTTGAAGAAATTAGAGATTACTATTTCGATATTATCGAAGCAACTCAGAACAATA
TGATTATTTATGCAATACCAGATTTAACAGGTGTGAATATTTCTATTGAACAATTCAGCGAGCTATTTAATCATGAAAAA
ATTGTTGGTGTTAAATATACAGCGCCAAACTTCTTCCTACTCGAACGTATTAGAAAAGCATTCCCAGACAAATTAATCTT
ATCTGGCTTTGATGAAATGTTAGTTCAAGCTACGATTTCTGGCGTAGATGGTGCAATTGGTTCTACATATAACGTTAATG
GTCGCCGTGCAAGAAAAATCTTCGACTTAGCACGACAAGGTCAAATTCAAGAAGCTTACCAACTGCAACATGATTCAAAC
GACATTATCGAAACAGTGTTATCAATGGGGATTTATCCAACATTGAAAGAAATATTACGTCATCGTGGCATTGATGCAGG
ATTACCGAAAAGACCTTTCAAACCTTTTAACGAAGCACATCGACAAACATTAGATCAACTCATTGCAAAATACGATTTAT
AG

Upstream 100 bases:

>100_bases
ATGACTACAATTTTCAAAAAGATATTGTTACATTTTATGATAGCGTTTACAATTATAGCTGTAAACTATATTATCAAATG
ATTTTTGGAGGGACTTCATA

Downstream 100 bases:

>100_bases
ACATCAAAGAATCAATACATTGTAAAGGGGATGTTGCCCATGAAAGAAGTTGGATTTGGCACACTAAACTGGGTTGCCGT
TATCATTTATCTACTAGCTA

Product: N-acetylneuraminate lyase

Products: NA

Alternate protein names: N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialic acid aldolase; Sialic acid lyase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQ
VGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEK
IVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSN
DIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL

Sequences:

>Translated_293_residues
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQ
VGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEK
IVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSN
DIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
>Mature_293_residues
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQ
VGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEK
IVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSN
DIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL

Specific function: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate [H]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family. NanA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=302, Percent_Identity=28.8079470198675, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=23.6933797909408, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789620, Length=289, Percent_Identity=36.6782006920415, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082415, Length=238, Percent_Identity=26.890756302521, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786463, Length=276, Percent_Identity=23.9130434782609, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788823, Length=227, Percent_Identity=26.431718061674, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR005264 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.1.3.3 [H]

Molecular weight: Translated: 33043; Mature: 33043

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQK
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCHHH
KQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIR
HHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKA
HHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
FPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCH
DIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQK
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCHHH
KQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIR
HHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
DYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKA
HHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
FPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCH
DIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA