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The map label for this gene is kbl [C]

Identifier: 57650969

GI number: 57650969

Start: 2483220

End: 2484335

Strand: Reverse

Name: kbl [C]

Synonym: SACOL2425

Alternate gene names: 57650969

Gene position: 2484335-2483220 (Counterclockwise)

Preceding gene: 57650970

Following gene: 57650968

Centisome position: 88.43

GC content: 30.38

Gene sequence:

>1116_bases
ATGAAGTTTCAAGAGCAAATTGATTTATTACAACAGAAAGGGTTATATCGGTCGCTTAAATCGGTAGGGTATATAGATAG
ACAGTATATTGAAGTAGAAAATAAGAGATGTACGAACTATACATCTAATGATTATTTAGGATTAGGTCAAATAGCGTTTG
ATAAGGATGATTTCGAAAGATTTATGCGGAAGTATAGTTATCACTTATCAAGTTCAAGATTAATTAGTGGAAGTTCGACA
GCTTATGAAGAAATTGAAACAATGTTAGCAGGTTGGCTCGGATATAGTGCATGTACTATCTTAAATAGTGGTTATGATGC
TAATTTGGCGTTATTTAATATTTTCAAAAATACAAATTGTGTCGTGTTTTCAGATCAAGAAAATCATGCGAGTATTATTG
ACGGTATTAAGTTAAGTGGTTTAGAAAAAGTGATATATAAGCATTTAGATATTGCTGATTTAGAAAAAAGGTTAGAGAAA
TACCCTAATCAAAATATACCAAAAATAATCATATCTGATAGTGTATTTTCAACGAATGGCGACGTTGTGGATATTGGTCA
ATTAGTCTCATTAAAGCATAAATATAACGCAACACTGATACTCGATGTTTCACATAGTTTTGGAATAGAGAATTACTCGA
ATTATCAAGGTGTAGATATACTCACTTCTAGTTTATCTAAAGCATGTGGTGCATACGGGGGTGTGATTTTAAGTTCAAAT
GATGTGAAGGATATGTTAATTAATCACGGTAGACCACTCATCTACTCAAGTAGTTTGCCAATTTATAATTTGTATTTTAT
AAAAAGAAACATTGAAAAGTTAATAAATGCTGATGATAGACGCACTAAATTAAATAGTTTGAGTAAATATTTTAACCAAA
AGTTAAAAGCACTCAATGTTAATTATAATAGTTCAAACTCGCCGATTAAGTTTATTGAGTTTGATGACATAGAAGCGGCT
GAGAACATTCATCAAACATTATTAAAGCATCATGTGTTTACAAGTTATTTAAGGTATCCAACTGTGACTAAGCCAATGTT
AAGAATATCATTGTCGTATTTTCATACTGAACAAGATATAGATAGGTTGTTTGAAATTTTGCATCAAGAAGATTGA

Upstream 100 bases:

>100_bases
CTAATTACTGGTGGGCAACCGAACCAATTAGACTACGATATGATTAATGATTTAGGCTTTGAAATTGATTATGACACTTG
TGAAAATAAGGAAAACAAGA

Downstream 100 bases:

>100_bases
GGTGATCGTCATGTATAGTATAAAAATGCGTTCTAGCAATCAAGATGTTCATATTAGTGGTGCTGAAACGATTTGTGAGT
TTGACAAAATAGAACAGACG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLEK
YPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGVDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED

Sequences:

>Translated_371_residues
MKFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLEK
YPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGVDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED
>Mature_371_residues
MKFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSST
AYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLEK
YPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGVDILTSSLSKACGAYGGVILSSN
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAA
ENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=378, Percent_Identity=26.7195767195767, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI284448556, Length=340, Percent_Identity=28.5294117647059, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI83977442, Length=391, Percent_Identity=27.8772378516624, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI83977440, Length=391, Percent_Identity=27.8772378516624, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI83977444, Length=391, Percent_Identity=27.8772378516624, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4502025, Length=393, Percent_Identity=26.2086513994911, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40316939, Length=393, Percent_Identity=26.2086513994911, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4758668, Length=355, Percent_Identity=24.7887323943662, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=25.4742547425474, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790046, Length=377, Percent_Identity=27.8514588859416, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=28.169014084507, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=29.8591549295775, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32566772, Length=335, Percent_Identity=24.7761194029851, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=320, Percent_Identity=26.5625, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=320, Percent_Identity=26.5625, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=394, Percent_Identity=27.9187817258883, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320267, Length=357, Percent_Identity=26.890756302521, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323954, Length=276, Percent_Identity=22.463768115942, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24662918, Length=345, Percent_Identity=30.1449275362319, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=28.7262872628726, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137420, Length=400, Percent_Identity=27.75, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24653280, Length=381, Percent_Identity=21.259842519685, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653276, Length=381, Percent_Identity=21.259842519685, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653278, Length=381, Percent_Identity=21.259842519685, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42562; Mature: 42562

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFER
CCHHHHHHHHHHCCHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEECHHHHHH
FMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNC
HHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCE
VVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLEKYPNQNIPKIIISDSVFSTNG
EEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCEECCCC
DVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGVDILTSSLSKACGAYGGVILSSN
CEEEHHHHHHHHHCCCEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCC
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNV
CHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEC
NYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDI
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHH
DRLFEILHQED
HHHHHHHHCCC
>Mature Secondary Structure
MKFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFER
CCHHHHHHHHHHCCHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEECHHHHHH
FMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNC
HHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCE
VVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLEKYPNQNIPKIIISDSVFSTNG
EEEECCCCCHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECCEECCCC
DVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGVDILTSSLSKACGAYGGVILSSN
CEEEHHHHHHHHHCCCEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCC
DVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNV
CHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEC
NYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDI
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHH
DRLFEILHQED
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA