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The map label for this gene is ilvD [H]

Identifier: 57650725

GI number: 57650725

Start: 2101069

End: 2102757

Strand: Direct

Name: ilvD [H]

Synonym: SACOL2042

Alternate gene names: 57650725

Gene position: 2101069-2102757 (Clockwise)

Preceding gene: 57650720

Following gene: 57650726

Centisome position: 74.79

GC content: 40.32

Gene sequence:

>1689_bases
ATGCGAAGCGACATGATCAAAAAAGGAGATCACCAAGCACCAGCAAGAAGTCTTTTACATGCCACGGGCGCGCTAAAAAG
TCCAACTGATATGAACAAACCATTTGTAGCTATTTGTAACTCTTATATTGATATTGTTCCTGGACATGTTCACTTGAGAG
AGCTTGCAGATATAGCTAAAGAAGCAATTAGAGAAGCCGGTGCCATTCCATTTGAATTCAATACAATTGGTGTTGATGAT
GGAATAGCTATGGGACATATCGGAATGCGATATTCTCTACCATCACGTGAAATTATTGCAGATGCAGCTGAAACTGTAAT
TAACGCTCATTGGTTTGACGGCGTATTTTACATTCCTAATTGTGACAAGATTACACCCGGTATGATTTTAGCAGCCATGA
GGACAAACGTACCAGCTATCTTTTGCTCTGGTGGACCAATGAAAGCTGGCTTATCTGCACATGGAAAAGCATTAACACTT
TCATCAATGTTTGAAGCAGTCGGCGCATTTAAAGAAGGATCGATTTCTAAAGAAGAATTTTTAGATATGGAACAAAATGC
CTGCCCTACTTGTGGTTCATGTGCTGGGATGTTTACTGCAAATTCAATGAACTGTTTGATGGAAGTTTTAGGTCTAGCAT
TACCATACAACGGTACTGCACTTGCAGTCAGTGATCAGCGACGAGAAATGATTCGCCAAGCAGCTTTTAAATTAGTTGAA
AATATTAAAAATGATTTAAAACCACGTGATATCGTTACTCGCGAAGCAATTGATGATGCATTTGCACTTGATATGGCTAT
GGGTGGTTCAACAAACACGGTACTGCATACGTTAGCCATTGCCAATGAAGCTGGTATTGATTATGACTTAGAGCGCATTA
ATGCTATTGCCAAACGCACGCCATATTTATCAAAAATAGCACCTAGTTCATCGTATTCAATGCATGATGTGCATGAAGCT
GGTGGCGTCCCAGCAATTATTAATGAATTGATGAAGAAAGATGGCACGTTACACCCAGATAGAATCACAGTTACTGGCAA
AACGTTACGTGAAAATAACGAAGGCAAAGAAATTAAGAACTTTGATGTCATTCACCCTCTTGATGCACCATATGATGCAC
AAGGCGGTTTATCTATCTTATTTGGTAATATCGCCCCTAAAGGCGCAGTTATTAAAGTTGGCGGCGTTGATCCATCTATC
AAAACATTTACTAGGAAAGCAATTTGTTTCAATTCGCATGATGAAGCTGTTGAAGCAATAGACAATCGTACCGTTCGTGC
AGGCCACGTCGTTGTCATTAGATATGAAGGACCTAAAGGTGGACCAGGTATGCCTGAAATGTTAGCACCTACTTCCTCTA
TTGTTGGTCGCGGCTTAGGTAAAGATGTTGCATTAATTACTGATGGGCGTTTTTCCGGTGCCACAAGAGGTATTGCAGTT
GGTCATATTTCCCCTGAAGCTGCATCTGGTGGACCAATTGCCTTAATTGAAGATGGTGATGAGATTACTATTGATTTAAC
AAATCGTACATTAAACGTAAACCAGCCTGAAGATGTTCTAGCGCGTCGCCGAGAATCTTTAACACCATTTAAAGCGAAAG
TAAAAACAGGTTATCTAGCTCGTTATACTGCCCTAGTAACTAGCGCAAATACAGGTGGCGTCATGCAAGTCCCTGAGAAT
TTAATTTAA

Upstream 100 bases:

>100_bases
CCAATAATATTGGGACGTTTTTTTATGTTTTATCTTTCAATTACTTATTTTTATTACTATAAAACATGATTAATCATTAA
AATTTACGGGGGAATTTACT

Downstream 100 bases:

>100_bases
TTTATTTTTATATTGGAGATGGTTAAAATGTCTAAAACTCAACATGAAGTAAACCAAAATATTGACCCTTTAAAAATGGC
TGAATCACTTGAACCTGAAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDD
GIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTL
SSMFEAVGAFKEGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVE
NIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEA
GGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSI
KTFTRKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAV
GHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPEN
LI

Sequences:

>Translated_562_residues
MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDD
GIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTL
SSMFEAVGAFKEGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVE
NIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEA
GGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSI
KTFTRKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAV
GHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPEN
LI
>Mature_562_residues
MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAKEAIREAGAIPFEFNTIGVDD
GIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTL
SSMFEAVGAFKEGSISKEEFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVE
NIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRTPYLSKIAPSSSYSMHDVHEA
GGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKNFDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSI
KTFTRKAICFNSHDEAVEAIDNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAV
GHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLARYTALVTSANTGGVMQVPEN
LI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=45.9637561779242, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1788157, Length=529, Percent_Identity=30.2457466918715, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=34.2574257425743, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI2367371, Length=505, Percent_Identity=32.4752475247525, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=567, Percent_Identity=40.0352733686067, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60122; Mature: 60122

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAK
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
EAIREAGAIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPN
HHHHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCC
CDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTLSSMFEAVGAFKEGSISKEEF
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHH
LDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVE
HCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHH
NIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRT
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
PYLSKIAPSSSYSMHDVHEAGGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKN
CCHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCCCCC
FDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSIKTFTRKAICFNSHDEAVEAI
CCEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHHEEECCCHHHHHHH
DNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAV
CCCEEEECEEEEEEECCCCCCCCCCHHHCCCHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLA
EECCCCCCCCCCEEEEECCCEEEEEEECCEEECCCCHHHHHHHHHCCCCHHHHHCCCHHH
RYTALVTSANTGGVMQVPENLI
EEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MRSDMIKKGDHQAPARSLLHATGALKSPTDMNKPFVAICNSYIDIVPGHVHLRELADIAK
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
EAIREAGAIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPN
HHHHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEECCC
CDKITPGMILAAMRTNVPAIFCSGGPMKAGLSAHGKALTLSSMFEAVGAFKEGSISKEEF
CCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHH
LDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPYNGTALAVSDQRREMIRQAAFKLVE
HCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHH
NIKNDLKPRDIVTREAIDDAFALDMAMGGSTNTVLHTLAIANEAGIDYDLERINAIAKRT
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
PYLSKIAPSSSYSMHDVHEAGGVPAIINELMKKDGTLHPDRITVTGKTLRENNEGKEIKN
CCHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECHHHHCCCCCCCCCC
FDVIHPLDAPYDAQGGLSILFGNIAPKGAVIKVGGVDPSIKTFTRKAICFNSHDEAVEAI
CCEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHHHHHEEECCCHHHHHHH
DNRTVRAGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKDVALITDGRFSGATRGIAV
CCCEEEECEEEEEEECCCCCCCCCCHHHCCCHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHISPEAASGGPIALIEDGDEITIDLTNRTLNVNQPEDVLARRRESLTPFKAKVKTGYLA
EECCCCCCCCCCEEEEECCCEEEEEEECCEEECCCCHHHHHHHHHCCCCHHHHHCCCHHH
RYTALVTSANTGGVMQVPENLI
EEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA