Click here to switch to the map view.

The map label for this gene is gnd

Identifier: 57650466

GI number: 57650466

Start: 1590298

End: 1591704

Strand: Reverse

Name: gnd

Synonym: SACOL1554

Alternate gene names: 57650466

Gene position: 1591704-1590298 (Counterclockwise)

Preceding gene: 57650467

Following gene: 57650465

Centisome position: 56.66

GC content: 34.33

Gene sequence:

>1407_bases
ATGACACAACAAATTGGAGTTATTGGTTTAGCCGTTATGGGTAAAAACCTAGCTTGGAATATTGAATCACGCGGATATAG
TGTATCTGTATTTAACCGCTCAAGTGAAAAAACTGATTTAATGGTTGAAGAATCAAAAGGGAAAAATATTCATCCAACGT
ATTCATTGGAAGAATTTGTTAATTCTTTAGAAAAACCACGTAAAATTTTATTAATGGTTCAAGCAGGTAAAGCTACGGAC
GCAACGATTGATAGTTTGTTACCTTTATTAGATGATGGAGATATTTTAATTGATGGTGGTAATACAAACTATCAAGATAC
TATCAGACGTAATAAAGCATTAGCACAAAGTGCAATCAACTTTATTGGTATGGGCGTTTCTGGTGGTGAAATTGGAGCGT
TAACTGGTCCGTCATTAATGCCGGGTGGACAAGAAGAAGCTTATAACAAAGTTGCAGATATTCTTGATGCAATTGCTGCA
AAGGCAAAAGACGGTGCTTCATGTGTTACTTATATTGGACCTAATGGTGCTGGACACTATGTGAAAATGGTACACAATGG
TATCGAATATGCTGACATGCAATTAATTGCAGAAAGTTATGCTATGATGAAAGAATTATTAGGCATGTCTCATGAAGACA
TTGCTCAAACGTTCAAAGACTGGAATGCTGGTGAATTAGAAAGTTATTTAATTGAAATCACTGGTGATATTTTCATGAAA
TTAGATGAAAATAAAGAAGCATTAGTTGAAAAAATTCTTGATACTGCAGGTCAAAAAGGTACAGGAAAATGGACTTCAAT
TAACGCATTAGAATTAGGTATTCCATTAACAATCATTACTGAATCTGTATTTGCACGTTTTATCTCTTCAATCAAAGAAG
AGCGCGTAAATGCTTCTAAAGAATTAAATGGTCCAAAAGCATCATTTGATGGTGACAAGAAAGACTTTTTAGAAAAAATT
CGTAAAGCATTATATATGAGTAAAATTTGTTCTTATGCACAAGGTTTCGCGCAAATGCGTAAAGCAAGTGAAGATAATGA
ATGGAATTTAAAACTTGGTGATTTAGCTATGATTTGGAGAGAAGGTTGCATTATCCGTGCACAATTCTTACAAAAGATCA
AAGATGCTTACGATAATAATCCAGGATTACAAAACTTATTGCTAGATCCTTACTTTAAAAACATCGTTACTGAATATCAA
GATGCGTTACGTGATGTTGTCGCAACTGGTGTTCAAAATGGTGTACCAACACCTGGTTTCTCATCAAGTATTAATTACTA
TGATAGTTACCGTGCTGCTGATTTACCTGCAAACTTAATTCAAGCACAACGTGACTACTTCGGTGCTCATACGTACGAAA
GAAAAGATAAAGAAGGCGTATTCCATACACAATGGATTGAAGAATAA

Upstream 100 bases:

>100_bases
ATAATCAAAATAGTTGCGCGACATTCGAAATGATTTAGTGTAGTGTATGTCTATTTTGTGATACAATACTAATGAAAAAT
CAACAAGTGAGGTAAGTAAT

Downstream 100 bases:

>100_bases
TATTGATTAAAGGATAGTTGAAAGATACTATCCTTTTTTATATCTTTTGATAAATATAAAAGAGAGTGTGATAGAGTAGC
TACAACCTATAAAAAATTAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFVNSLEKPRKILLMVQAGKATD
ATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAA
KAKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMK
LDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKELNGPKASFDGDKKDFLEKI
RKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQ
DALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE

Sequences:

>Translated_468_residues
MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFVNSLEKPRKILLMVQAGKATD
ATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAA
KAKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMK
LDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKELNGPKASFDGDKKDFLEKI
RKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQ
DALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE
>Mature_467_residues
TQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFVNSLEKPRKILLMVQAGKATDA
TIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAINFIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAAK
AKDGASCVTYIGPNGAGHYVKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMKL
DENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASKELNGPKASFDGDKKDFLEKIR
KALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWREGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQD
ALRDVVATGVQNGVPTPGFSSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=464, Percent_Identity=56.6810344827586, Blast_Score=523, Evalue=1e-148,
Organism=Escherichia coli, GI1788341, Length=465, Percent_Identity=67.0967741935484, Blast_Score=657, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=466, Percent_Identity=51.0729613733906, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=51.1061946902655, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321977, Length=456, Percent_Identity=51.0964912280702, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24639279, Length=464, Percent_Identity=52.3706896551724, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_STAAC (Q5HFR2)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186395.1
- ProteinModelPortal:   Q5HFR2
- SMR:   Q5HFR2
- STRING:   Q5HFR2
- EnsemblBacteria:   EBSTAT00000010017
- GeneID:   3237561
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1554
- TIGR:   SACOL1554
- eggNOG:   COG0362
- GeneTree:   EBGT00050000025238
- HOGENOM:   HBG286913
- OMA:   CIIRAGF
- ProtClustDB:   PRK09287
- BioCyc:   SAUR93062:SACOL1554-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 51803; Mature: 51672

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 182-182 ACT_SITE 189-189 BINDING 101-101 BINDING 101-101 BINDING 190-190 BINDING 259-259 BINDING 286-286 BINDING 444-444 BINDING 450-450

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFV
CCCCCCEEEHEEECCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHH
NSLEKPRKILLMVQAGKATDATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAIN
HHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
FIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAAKAKDGASCVTYIGPNGAGHY
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
VKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEECCEEEE
LDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASK
ECCCHHHHHHHHHHHCCCCCCCCCEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHH
ELNGPKASFDGDKKDFLEKIRKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHH
EGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQDALRDVVATGVQNGVPTPGF
CCCCHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE
CCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
TQQIGVIGLAVMGKNLAWNIESRGYSVSVFNRSSEKTDLMVEESKGKNIHPTYSLEEFV
CCCCCEEEHEEECCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHH
NSLEKPRKILLMVQAGKATDATIDSLLPLLDDGDILIDGGNTNYQDTIRRNKALAQSAIN
HHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
FIGMGVSGGEIGALTGPSLMPGGQEEAYNKVADILDAIAAKAKDGASCVTYIGPNGAGHY
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
VKMVHNGIEYADMQLIAESYAMMKELLGMSHEDIAQTFKDWNAGELESYLIEITGDIFMK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHEECCEEEE
LDENKEALVEKILDTAGQKGTGKWTSINALELGIPLTIITESVFARFISSIKEERVNASK
ECCCHHHHHHHHHHHCCCCCCCCCEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHH
ELNGPKASFDGDKKDFLEKIRKALYMSKICSYAQGFAQMRKASEDNEWNLKLGDLAMIWR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHH
EGCIIRAQFLQKIKDAYDNNPGLQNLLLDPYFKNIVTEYQDALRDVVATGVQNGVPTPGF
CCCCHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSSINYYDSYRAADLPANLIQAQRDYFGAHTYERKDKEGVFHTQWIEE
CCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA