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The map label for this gene is ubiE

Identifier: 57650426

GI number: 57650426

Start: 1550538

End: 1551263

Strand: Reverse

Name: ubiE

Synonym: SACOL1511

Alternate gene names: 57650426

Gene position: 1551263-1550538 (Counterclockwise)

Preceding gene: 57650427

Following gene: 57650425

Centisome position: 55.22

GC content: 34.16

Gene sequence:

>726_bases
ATGGCTGACAATAAAGCAAATAAAGAGCAAGTACATCGCGTTTTTCAAAATATTTCAAAAAAATATGATAGATTAAATAA
TATTATTAGTTTTGAGCAGCATAAAGTATGGAGAAAACGCGTCATGAAAGACATGGGTGTTAGAAAAGGGACGAAAGCAT
TAGATGTTTGTTGTGGTACTGGTGATTGGACAATCGCATTAAGCAAAGCTGTAGGACCAACAGGTGAAGTTACTGGTATT
GACTTTAGTGAGAATATGTTAGAAGTAGGAAAAGAAAAAACTGCTTCAATGGAAAATGTTAAACTTGTTCATGGTGATGC
AATGGAATTGCCGTTTGAAGACAATTCTTTTGATTATGTAACAATTGGGTTTGGATTAAGAAATGTGCCAGACTATTTAG
TCGCGTTAAAAGAAATGAATAGAGTACTTAAACCAGGTGGTATGGTGGTATGTCTTGAAACGAGCCAACCAACTTTGCCA
GTCTTTAAACAAATGTATGCACTATACTTTAAATTTGTTATGCCTATTTTTGGAAAATTATTTGCAAAATCAAAAGAAGA
ATATGAATGGTTACAGCAATCTACGTTTAATTTTCCTGGAAAAGAAGAGTTGAAGCGCATGTTTGAAGAAGCAGGTTTCA
TAAATGTAAGAGTACGTAGTTTTACAGGGGGCGTTGCTGCAATGCACCTTGGCTATAAAGAAAAAGATAATACCAAAGGT
GATTAA

Upstream 100 bases:

>100_bases
ATTACTATCCATCATACTTCAAGAAATATAATCAAAGTGAAGTAAAGCATTACTTACACGATATCCAAAAAAGTTATTTA
AAAAGTAGAGGTAATTAAGC

Downstream 100 bases:

>100_bases
CGTGGCAAAGTTAAACATGAACAATGAAATTAAGAAAGTGGAACAACGACTTGAAAAGGCAATAAAAAGTAAAGATTCTG
TATTAGAACAGGCATCATTA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGI
DFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVTIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLP
VFKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKG
D

Sequences:

>Translated_241_residues
MADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGI
DFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVTIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLP
VFKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKG
D
>Mature_240_residues
ADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGID
FSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVTIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPV
FKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKGD

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=260, Percent_Identity=35.7692307692308, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI48994983, Length=228, Percent_Identity=41.6666666666667, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17557039, Length=238, Percent_Identity=35.2941176470588, Blast_Score=153, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25143945, Length=119, Percent_Identity=30.2521008403361, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=251, Percent_Identity=30.6772908366534, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24641702, Length=246, Percent_Identity=35.7723577235772, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_STAA1 (A7X2H6)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442049.1
- ProteinModelPortal:   A7X2H6
- STRING:   A7X2H6
- EnsemblBacteria:   EBSTAT00000004549
- GeneID:   5559333
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1459
- eggNOG:   COG2226
- GeneTree:   EBGT00050000024451
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   SAUR418127:SAHV_1459-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27423; Mature: 27292

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC
GDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYV
CCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCCEE
TIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKL
EECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKG
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCCCCCCC
D
C
>Mature Secondary Structure 
ADNKANKEQVHRVFQNISKKYDRLNNIISFEQHKVWRKRVMKDMGVRKGTKALDVCCGT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECC
GDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYV
CCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEECCCEECCCCCCCCCEE
TIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKL
EECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
FAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKG
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA