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The map label for this gene is ndk

Identifier: 57650424

GI number: 57650424

Start: 1549036

End: 1549485

Strand: Reverse

Name: ndk

Synonym: SACOL1509

Alternate gene names: 57650424

Gene position: 1549485-1549036 (Counterclockwise)

Preceding gene: 57650425

Following gene: 57650423

Centisome position: 55.15

GC content: 34.0

Gene sequence:

>450_bases
GTGGAACGTACATTTTTAATGATTAAACCAGATGCAGTACAAAGAAATCTAATTGGTGAAGTAATTTCAAGAATTGAAAG
AAAAGGACTAAAACTTGTCGGTGGTAAATTAATGCAAGTACCAATGGAACTTGCTGAAACACATTATGGTGAACACCAAG
GTAAACCATTTTATAATGATTTAATTTCATTTATTACATCAGCACCAGTGTTCGCAATGGTAGTTGAAGGTGAAGATGCA
GTTAATGTATCTAGACATATTATTGGCAGCACCAATCCTTCAGAAGCTTCACCAGGATCAATTAGAGGTGATTTAGGTTT
AACTGTTGGTAGAAATATCATTCACGGTTCAGATTCATTAGAGTCTGCTGAACGTGAAATTAATCTATGGTTTAATGAAA
ATGAAATTACTAGCTATGCTTCACCACGTGATGCATGGTTATATGAATAA

Upstream 100 bases:

>100_bases
AACACGTAGTATTTATGAAAAGTATTGAAAGCGCTTTACCAACCTGTTAATATATAATAGTAATATACATAAACCTATTA
AACACAGGGGGATACATAAA

Downstream 100 bases:

>100_bases
AATATAAACTGTAAACCTTTACGATTTATTTATAAAGGTAGAAAGGGTTTTGTTATGTGGTTAGTCATTATGATTATACA
TAACAAGGCCCGTTTTTTAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDA
VNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE

Sequences:

>Translated_149_residues
MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDA
VNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE
>Mature_149_residues
MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDA
VNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=54.0540540540541, Blast_Score=176, Evalue=6e-45,
Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=51.6778523489933, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=51.6778523489933, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=48.993288590604, Blast_Score=163, Evalue=6e-41,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=48.993288590604, Blast_Score=163, Evalue=6e-41,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=48.993288590604, Blast_Score=163, Evalue=6e-41,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=48.993288590604, Blast_Score=163, Evalue=6e-41,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=48.993288590604, Blast_Score=163, Evalue=6e-41,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=51.0791366906475, Blast_Score=157, Evalue=3e-39,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.8421052631579, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.8421052631579, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI5031951, Length=141, Percent_Identity=36.8794326241135, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=31.6176470588235, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=45.985401459854, Blast_Score=140, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=48.993288590604, Blast_Score=157, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=32.5757575757576, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=52.027027027027, Blast_Score=177, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=50, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=34.5588235294118, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_STAA1 (A7X2H3)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442047.1
- ProteinModelPortal:   A7X2H3
- SMR:   A7X2H3
- STRING:   A7X2H3
- EnsemblBacteria:   EBSTAT00000003246
- GeneID:   5559968
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1457
- eggNOG:   COG0105
- GeneTree:   EBGT00050000025527
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   SAUR418127:SAHV_1457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16575; Mature: 16575

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYND
CCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHH
LISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSL
HHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHCCEEECCCCHH
ESAEREINLWFNENEITSYASPRDAWLYE
HHCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MERTFLMIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYND
CCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHH
LISFITSAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSL
HHHHHHCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHCCEEECCCCHH
ESAEREINLWFNENEITSYASPRDAWLYE
HHCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA