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The map label for this gene is trpA [H]

Identifier: 57650377

GI number: 57650377

Start: 1419799

End: 1420527

Strand: Direct

Name: trpA [H]

Synonym: SACOL1409

Alternate gene names: 57650377

Gene position: 1419799-1420527 (Clockwise)

Preceding gene: 57650376

Following gene: 57651875

Centisome position: 50.54

GC content: 34.16

Gene sequence:

>729_bases
ATGACTAAATTATTTATACCTTATATTATGGGCAATAAAGATTTGATTGAAAATGCAACATTGTTGAGTGAAAATGGTGC
AGATATAATTGAAATTGGAGTACCTTTCTCTGATCCGGTTGCTGATGGTCCAGTTATCATGGAAGCAGGTCAACAAGCGA
TTAAACAAGGCATCACGATAGATTATATTTTCAATCAATTAGAAAAACATGGTGATCAAATTAAGTGTAACTATGTATTA
ATGACGTATTATAATATTATTTGTCATTATGGAGAACAAGCGTTTTTTGAAAAATGTCGAGATACTGGTGTCTACGGCTT
AATTATTCCTGATTTACCATATGAATTATCGCAGCGTTTAAAACAACAATTTAGTCACTATGGCGTCAAAATCATATCGT
TAGTTGCGATGACTACTGATGACAAACGTATAAAAGATATCGTATCCCATGCGGAAGGCTTTATTTATACTGTGACGATG
AATGCGACAACAGGGCAAAACGGTGCGTTTCATCCAGAATTAAAACGAAAAATTGAGTCAATTAAAGCGATAGCCAATGT
GCCAGTTGTCGCAGGATTTGGTATAAGAACACCACAACATGTTGCAGATATAAAAGAGGTTGCAGATGGCATTGTCATTG
GTAGCGAAATCGTTAAGCGATTTAAATCTAACACGCGTGAGGAAATCATTAAATATTTACAATCTATCCAACAAACATTG
AATAATTAA

Upstream 100 bases:

>100_bases
ACGATGTCGAAAGAAGATATTATTGTAGTAACTATTTCTGGACGTGGCGATAAAGATATGGAAACAATTAGACAATATAT
GGTAGAGCGAGGTCTTGCAA

Downstream 100 bases:

>100_bases
GTTTACTTGATTTAAAAAAATTAGGCGAATACTGTTTGAAAAAGTGAAAAACGGTGAATTATAAAATTGAATAGAAATGA
TACAAAAGTAATATGAGCAA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFNQLEKHGDQIKCNYVL
MTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTM
NATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTL
NN

Sequences:

>Translated_242_residues
MTKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFNQLEKHGDQIKCNYVL
MTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTM
NATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTL
NN
>Mature_241_residues
TKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITIDYIFNQLEKHGDQIKCNYVLM
TYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRLKQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMN
ATTGQNGAFHPELKRKIESIKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTLN
N

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=206, Percent_Identity=31.0679611650485, Blast_Score=101, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321412, Length=209, Percent_Identity=35.8851674641148, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27118; Mature: 26986

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITI
CCEEEEEEEECCHHHHHCCHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCH
DYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRL
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCCHHHHHHH
KQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNGAFHPELKRKIES
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
IKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTL
HHHHHCCCEEECCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHH
NN
CC
>Mature Secondary Structure 
TKLFIPYIMGNKDLIENATLLSENGADIIEIGVPFSDPVADGPVIMEAGQQAIKQGITI
CEEEEEEEECCHHHHHCCHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCH
DYIFNQLEKHGDQIKCNYVLMTYYNIICHYGEQAFFEKCRDTGVYGLIIPDLPYELSQRL
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCCCHHHHHHH
KQQFSHYGVKIISLVAMTTDDKRIKDIVSHAEGFIYTVTMNATTGQNGAFHPELKRKIES
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
IKAIANVPVVAGFGIRTPQHVADIKEVADGIVIGSEIVKRFKSNTREEIIKYLQSIQQTL
HHHHHCCCEEECCCCCCHHHHHHHHHHHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHH
NN
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA