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The map label for this gene is uvrC [H]

Identifier: 57238119

GI number: 57238119

Start: 1294817

End: 1296619

Strand: Reverse

Name: uvrC [H]

Synonym: CJE1382

Alternate gene names: 57238119

Gene position: 1296619-1294817 (Counterclockwise)

Preceding gene: 57238120

Following gene: 57238118

Centisome position: 72.93

GC content: 29.67

Gene sequence:

>1803_bases
TTGATTAAAGAGAATTTAGAAAATGAGTTAAAAACTCTTCCCAATAGTGCTGGAGTGTATCAATATTTTAATCAAGAAGG
AAAGCTTTTATATGTAGGCAAGGCTAAAAATCTTAAAAATCGTGTCAAATCTTATTTTGCCTTTACTCCAAATTTACATG
CAAATCCAAGAAATTCTTTAAGAATTCAAAAAATGATTGAAGAAACAGTGCATTTGGAATTTATTGCTACTAATTCAGAG
GCTGATGCTTTGATTTTAGAAAATTCTTTTATCAAACAACTGCATCCAAAATATAATATTTTGCTAAGAGATGATAAAAC
TTATCCTTATATTTATGTGGATTTTGAAGAAGAATTTCCACGCTTTGAGATCACTAGAAAATTAGTAAAAAAAAGCAAAA
TTAAATATTTTGGCCCTTTTTTTAAAGGCGCTAGAGAGCTTTTAGATGCGCTTTATTTATACTATCCTTTAAAGCAAAAA
GCAAGTTGTAAATCCCCTTGTATTTTTTATCAAATTTCTCGTTGTCTTGCACCTTGTGATAAACTCATCAGCAGGGAAAA
ATACCTTGAAATTTTAGATGAGGCTATACACGCACTTTTAAATCCTAGTGTTTTGCTTAAAAACTTAGAAAAACAAATGC
TTGTTTTAGCACAAAATGAAAATTACGAAGAAGCAGCTAAAGTAAGAGATCAGATTGCAATGATTAAAGATTTGGAAGTT
AAGGTTGAAATAGATATTGCGAAATTAGAAGATTTTGAAGTATTTGCTTTAGCTTTTAAAAATTCCGTGCTTTCAACCTT
GCGTTTTGTGGTGCAAAATGGAAAAATTATCAGTGCAAATTCTAAGATTACTCCTATAAGAAATGATATACAATGGGATC
AAAATGAAATTTATAAGCAACTGATTTTAGAAAATTTTAGCATGGATATTCCTTTGCTTGCAAATGTTATTTATGTTTAT
GAAGAATTTGAAGATAGAGTGCTTTTAGAAGAAATTTTAAGCCAAAGGTTTGATAAAAAAATCAGTATTAAAATCCCTAA
AATAGGAGAAAAAAGAAGAATTTGTGATTTGGCTTTTCAAAATGCCCTTTTAAATATAGAAAAAGAGCAAAAAAATCATG
ATTTTACTATACAAAAAGAATTAAAGTTTTATTTTGAGCTTGAAAATTTACCAAATGATATAGAAATTTTTGACAATTCT
CATTTGCAAGGCGTGGCAAATGTTGGAGCTATGGTAACTTATAGAATAAATTCTTGGGATAAGTCAAAATATAGAAAATT
TCATTTAAAACATAAAAATGACTATGATCAAATGCGTGAAGTTTTAACGCGTAGGGCTTTGGACTTTGATAAAATACCTC
CTCCTGATTTATGGCTTATAGATGGGGGAAAGGCTTTGCTTGATTTGGCTAAAGAAATCATTGTAAGTAGTGGGGCAAAT
GTCGATATTTTAGCTATTTCAAAAGAAAAAATCGATGCAAAAGCACATAGAGCTAAAGGGGGTGCTAAGGATAAAATTCA
TTCCTTAAAAGGAGAATTTAGTCTAAGCATTAACGATAAAAAACTACAATTCTTACAGAAATTAAGAGATGAAGCACACC
GTTTTGCTATCAGCTTTCATCAAAATACTAAGAAAAAACAGGACTTGAAAAGTTCTAAGCTTGCAAATTTAGGACTTAGT
TCAGGGGTTATACAAAAACTTTTAGCGTATTATGGAAATTTTGAATCTATATATAAGGCTGATTTTAAAGATCTTACAAT
GCTTGTAGGCAGGAAAGCGGCGCAAAAGATAAAGGAAAATTGA

Upstream 100 bases:

>100_bases
TTGGAGCTTTCTAAGGGTGAATTTAAAAATTGCTTTGAAGATAAAAAATTATTTAAGAAATTTGAAGATTTAAGAGAGCT
TATAAAAAAAGGTTCTAATC

Downstream 100 bases:

>100_bases
TTTGATATTAGCAGGGATAATTTTTATTTTTAATCTAATTTTAGCGTATTTAAGTATTGATATCTCAAAGCTTGATAGTG
TTACTGAACAACTGAAAATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MIKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSLRIQKMIEETVHLEFIATNSE
ADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQK
ASCKSPCIFYQISRCLAPCDKLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEV
KVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIRNDIQWDQNEIYKQLILENFSMDIPLLANVIYVY
EEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNS
HLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGAN
VDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLS
SGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN

Sequences:

>Translated_600_residues
MIKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSLRIQKMIEETVHLEFIATNSE
ADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQK
ASCKSPCIFYQISRCLAPCDKLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEV
KVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIRNDIQWDQNEIYKQLILENFSMDIPLLANVIYVY
EEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNS
HLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGAN
VDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLS
SGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN
>Mature_600_residues
MIKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSLRIQKMIEETVHLEFIATNSE
ADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQK
ASCKSPCIFYQISRCLAPCDKLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEV
KVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIRNDIQWDQNEIYKQLILENFSMDIPLLANVIYVY
EEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNS
HLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGAN
VDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLS
SGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=606, Percent_Identity=30.5280528052805, Blast_Score=241, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69691; Mature: 69691

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSL
CCCCHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHEEECCCCCCCCCCHH
RIQKMIEETVHLEFIATNSEADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFP
HHHHHHHHHHEEEEEEECCCCCEEEECHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCC
RFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQKASCKSPCIFYQISRCLAPCD
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCEE
KVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIRNDIQWDQNEIYKQ
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
LILENFSMDIPLLANVIYVYEEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
NALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNSHLQGVANVGAMVTYRINSWD
HHHHCCHHHCCCCCCEEEEHHEEEEEECCCCCCEEEECCCCCCHHHCCCEEEEEEECCCC
KSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGAN
CCHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCC
VDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFH
EEEEEECHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEC
QNTKKKQDLKSSKLANLGLSSGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSL
CCCCHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHEEECCCCCCCCCCHH
RIQKMIEETVHLEFIATNSEADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFP
HHHHHHHHHHEEEEEEECCCCCEEEECHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCC
RFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQKASCKSPCIFYQISRCLAPCD
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCEE
KVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIRNDIQWDQNEIYKQ
EEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
LILENFSMDIPLLANVIYVYEEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
NALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNSHLQGVANVGAMVTYRINSWD
HHHHCCHHHCCCCCCEEEEHHEEEEEECCCCCCEEEECCCCCCHHHCCCEEEEEEECCCC
KSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGAN
CCHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCC
VDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFH
EEEEEECHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEC
QNTKKKQDLKSSKLANLGLSSGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA