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The map label for this gene is cpxA [H]

Identifier: 57238098

GI number: 57238098

Start: 1275045

End: 1276292

Strand: Reverse

Name: cpxA [H]

Synonym: CJE1361

Alternate gene names: 57238098

Gene position: 1276292-1275045 (Counterclockwise)

Preceding gene: 57238099

Following gene: 57238095

Centisome position: 71.79

GC content: 27.32

Gene sequence:

>1248_bases
ATGAATAAATCTTCGATTTTTTATACTATAACTTTTATTTTTATTTTTGCTGGGGTTAGTGTTATACTTGGCTTTTTGTG
GCTTATAGAATACGATCAGCAAAATTATACTAGAGAATTAAACACAAAATATTCTTTGATAGCTAATGCAAGGCTCTTAA
ATTTTGCAGGAGTTATCAGTGAAAAAGAATTTGAAGAGCAGACAAAAAATTATAATAAAATGGATGAGATAACAGAAGCA
AAGCAGATCCGTAAAATTCTTTTTAGAGGTGATGTTTTAGCTAGGGTTGAGGTTAACAATGGCTTAATCGAGATTATTTC
TTATAATAGACAGGTGTATTTAAATATTATTTATGATGGAAAGGTTTATCTTTATAAGGATCAAGATTATCAAACCTATA
GGTATTTTATTATCAAAGCTATAGCTGTAGCTGTGATTTGTATTCTTGTATTGCTTTATATTTATATATTTAAAAAATTA
AAACCACTTAAAAGACTTAAAAAACAAATTGATAAATTTGCCCAAGGAAAGCTTGGTGATATAGAAGATGTAAGCACTGG
GGTGGATGAAATTTCACAAGTAAGTGAAGCTTTTTATCAAGCTATTGTTCAAATTCGAAAGTTAAACCAATCTCGTCAGT
TTTTTTTAAGAAATATTATGCATGAACTCAAAACTCCTATTACTAAAGGGCTTTTAACTTTAGAAATGATAGAAGATAAT
AAATATAAAGAGCGCTTAAATGGGGTTTTTACTAGACTTGAAATTTTAATTAATGAATTTGCTGCTATTGAGCAAATTAC
TTCAGGGGCTGCTTTTATAAATAGAAAAAAATACAATATTTTAGATGTTTTAGATGAAGCCAAAGAAATTGCAATGCGAG
ATGATAGCAATATACGTATTTTTATGGAAGAAAGTTTTTTTGTAAATGTGGATTTTAAACTTTTTACTACGGCGATTAAA
AATATGATAGATAATGGTATTAAACATTCTGAAGATGGGTTTGTGCAAATTGATATTATAGATGATTATATTTGTTTTAA
AAATCGTGGTCCTGAGCTTAACAATACTTTAGAATACTATACTCAAGCTTTTACTCAAGGATCAAAACAAAAATCAAGTT
TTGGATTAGGGCTTTATATTGTAAATACTATTTTAGAAACACATGGAATGAAGCTTGATTATTTATATGAAGATGGGGTA
AATTTGTTTTATTTTAGAAATTTAAAAAGTGTTATTGTTAAGGAGTAA

Upstream 100 bases:

>100_bases
TAGATGTTATTATCAGTAGAATTCGTCAAAAGATGGGAGATGATCCAAAAACTCCAAAATATATTCACTCTATACGTGGA
ATAGGTTATAAGCTTACTCA

Downstream 100 bases:

>100_bases
ATTAATTTTTTTACATAAAAAATGCATTTTTGTGAAAAAACCCTTGACAAAGTTTTTTAATTTCACTATAATCACATTTT
ACTTTTAAATATTCCGGATT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNKSSIFYTITFIFIFAGVSVILGFLWLIEYDQQNYTRELNTKYSLIANARLLNFAGVISEKEFEEQTKNYNKMDEITEA
KQIRKILFRGDVLARVEVNNGLIEIISYNRQVYLNIIYDGKVYLYKDQDYQTYRYFIIKAIAVAVICILVLLYIYIFKKL
KPLKRLKKQIDKFAQGKLGDIEDVSTGVDEISQVSEAFYQAIVQIRKLNQSRQFFLRNIMHELKTPITKGLLTLEMIEDN
KYKERLNGVFTRLEILINEFAAIEQITSGAAFINRKKYNILDVLDEAKEIAMRDDSNIRIFMEESFFVNVDFKLFTTAIK
NMIDNGIKHSEDGFVQIDIIDDYICFKNRGPELNNTLEYYTQAFTQGSKQKSSFGLGLYIVNTILETHGMKLDYLYEDGV
NLFYFRNLKSVIVKE

Sequences:

>Translated_415_residues
MNKSSIFYTITFIFIFAGVSVILGFLWLIEYDQQNYTRELNTKYSLIANARLLNFAGVISEKEFEEQTKNYNKMDEITEA
KQIRKILFRGDVLARVEVNNGLIEIISYNRQVYLNIIYDGKVYLYKDQDYQTYRYFIIKAIAVAVICILVLLYIYIFKKL
KPLKRLKKQIDKFAQGKLGDIEDVSTGVDEISQVSEAFYQAIVQIRKLNQSRQFFLRNIMHELKTPITKGLLTLEMIEDN
KYKERLNGVFTRLEILINEFAAIEQITSGAAFINRKKYNILDVLDEAKEIAMRDDSNIRIFMEESFFVNVDFKLFTTAIK
NMIDNGIKHSEDGFVQIDIIDDYICFKNRGPELNNTLEYYTQAFTQGSKQKSSFGLGLYIVNTILETHGMKLDYLYEDGV
NLFYFRNLKSVIVKE
>Mature_415_residues
MNKSSIFYTITFIFIFAGVSVILGFLWLIEYDQQNYTRELNTKYSLIANARLLNFAGVISEKEFEEQTKNYNKMDEITEA
KQIRKILFRGDVLARVEVNNGLIEIISYNRQVYLNIIYDGKVYLYKDQDYQTYRYFIIKAIAVAVICILVLLYIYIFKKL
KPLKRLKKQIDKFAQGKLGDIEDVSTGVDEISQVSEAFYQAIVQIRKLNQSRQFFLRNIMHELKTPITKGLLTLEMIEDN
KYKERLNGVFTRLEILINEFAAIEQITSGAAFINRKKYNILDVLDEAKEIAMRDDSNIRIFMEESFFVNVDFKLFTTAIK
NMIDNGIKHSEDGFVQIDIIDDYICFKNRGPELNNTLEYYTQAFTQGSKQKSSFGLGLYIVNTILETHGMKLDYLYEDGV
NLFYFRNLKSVIVKE

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48527; Mature: 48527

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSSIFYTITFIFIFAGVSVILGFLWLIEYDQQNYTRELNTKYSLIANARLLNFAGVIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
EKEFEEQTKNYNKMDEITEAKQIRKILFRGDVLARVEVNNGLIEIISYNRQVYLNIIYDG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCEEEEEEEEEC
KVYLYKDQDYQTYRYFIIKAIAVAVICILVLLYIYIFKKLKPLKRLKKQIDKFAQGKLGD
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IEDVSTGVDEISQVSEAFYQAIVQIRKLNQSRQFFLRNIMHELKTPITKGLLTLEMIEDN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHCCEEEEECCCC
KYKERLNGVFTRLEILINEFAAIEQITSGAAFINRKKYNILDVLDEAKEIAMRDDSNIRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
FMEESFFVNVDFKLFTTAIKNMIDNGIKHSEDGFVQIDIIDDYICFKNRGPELNNTLEYY
EEECCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEECCCCCCCCHHHHHH
TQAFTQGSKQKSSFGLGLYIVNTILETHGMKLDYLYEDGVNLFYFRNLKSVIVKE
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCHHHHHCCC
>Mature Secondary Structure
MNKSSIFYTITFIFIFAGVSVILGFLWLIEYDQQNYTRELNTKYSLIANARLLNFAGVIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
EKEFEEQTKNYNKMDEITEAKQIRKILFRGDVLARVEVNNGLIEIISYNRQVYLNIIYDG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCEEEEEEEEEC
KVYLYKDQDYQTYRYFIIKAIAVAVICILVLLYIYIFKKLKPLKRLKKQIDKFAQGKLGD
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IEDVSTGVDEISQVSEAFYQAIVQIRKLNQSRQFFLRNIMHELKTPITKGLLTLEMIEDN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHCCEEEEECCCC
KYKERLNGVFTRLEILINEFAAIEQITSGAAFINRKKYNILDVLDEAKEIAMRDDSNIRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEE
FMEESFFVNVDFKLFTTAIKNMIDNGIKHSEDGFVQIDIIDDYICFKNRGPELNNTLEYY
EEECCEEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEECCCCCCCCHHHHHH
TQAFTQGSKQKSSFGLGLYIVNTILETHGMKLDYLYEDGVNLFYFRNLKSVIVKE
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]