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The map label for this gene is copA [H]

Identifier: 57238033

GI number: 57238033

Start: 1212547

End: 1214646

Strand: Reverse

Name: copA [H]

Synonym: CJE1295

Alternate gene names: 57238033

Gene position: 1214646-1212547 (Counterclockwise)

Preceding gene: 57238034

Following gene: 57238030

Centisome position: 68.32

GC content: 30.86

Gene sequence:

>2100_bases
ATGGAAGAATTGCGTATAAAAATAGGCAAAATGACTTGCGTTAATTGTTCTAACGCTATAGAAAGAGCTTGTAAAAAAAT
TGATGGTGTTAAAGATGCTAGTGTTTCTTATGTGAATTCTAGCGGGGTTTTTTTACTTGAAGATCAAGAAAAACGCAAGG
ATATCATCGCAAAAATTCAAAATTTAGGCTTTGAAATTTTAGAAGATGAACAAAGCTTGAACGCATACAAGGCAAAAAAA
CACTTAGAATTAAGAAAAAATTTGCTCTTAAGTATAGTTTTGAGTGTGATTATTATGTATTTTGAAATGTTTGTTAAAAG
TTCTTTTTCTCAAAATATCCAAATGGCTTTGAGTTTTTTTGGGATATTTTATTGTGGGAGAGACTTTTTTTCTCATGCTT
TTTTAGGACTTAAAAGTAAAAATTTAGATATGAATACCCTTGTAGCTTTGGGGACTTTGAGTGCTTTTGTGTATTCTTTT
TTGGTGTATTTGCAAATTTTCAAAGAAGAAGATTTGTATTTTAGTGGTGCAATGATGATTATTTCCTTTGTGCTTTTAGG
AAAATATCTTGAAAGTAAGGCTAAATTTAAGGCACAAGATTATCAAAGAATTTTAGAAAATATAGACACAAAAAAGACAA
AAATTTTGCTTGAAGATGAAAGTATCAAAGAAATTTCAAGTTCTTTTGTCAAAAGTGGCGATGTACTTTTGGTAAAAGAA
GGAGAAAGTATTGTTGCAGATGGAATAGTGCTTTTAGGGAGTGCAGAGCTTGATATGAGTTTTTTAAATGGGGAGTTTTT
GCCTGTTTTAAAAAAAGAAGGCGATGAAGTTCAAGCAGGAGCAGTAGTTTTAAATGGTGCTTTAAGGATCAAAGCAAACA
AAAAGGCCATGGATAGTACTTTAGAACAAATCAAAAATCTAGTTTTTGAAGCAGGAAGTATCAAAAGTCCTTTGGCAAAT
TTAGCAGATCAAATTTCTAAATACTTTGTAGGGGGTATAATATTTTTTGCTTTTTTAGTTTTTGTTTTTTGGGTGCTAAA
AGCAGATTTAAATACAGCTTTTTTACACTCTTGTGCTGTGCTTTTGATCTCTTGTCCTTGTGCTTTAGGTCTTGCAACGC
CTATAGCTTTGGTTGTGGCAAGTGCAAATGCGGCAAAAAATTTCATTCTTATTAAAAATCCTGCTGCTTTAGAAAAATTA
GCCTTAGTTAAGTATGCTTTTTTTGATAAAACGGGTACATTAACAAAGGAAAAATTGAGTGTTTTTAAACACAATCTTTC
TAAAGATGATTTTGATAAATTATGTCAAATTGAAAGTTTAAGCTCTCATCCTATAGCCAAGGCTTTACATAAAGATCAAA
TTTGTGATTTAAAGGGTGAGGGAAGAGTGATTGTGGGTTCTGGCATAAAATACAAAGAAGATAATGATAATTATCTCGTA
GGCAGTGCGCAGTTTTTGCACGAAAATGAAATTGATACAAAAGAAAGTGATATCTTTTTTGACTCTTTTAAAGAATATGT
TAGAGTGTATTTTGCTAAGAATAAAAAGTGTTTAGGCGGTGTTTTATTAAGCAATGCTTTAAAAGATGGAGCCAAAGAGC
TTGTGTTAAATTTGAAAGAGCAAAATCTTAAAACTTTTATTTTAAGCGGCGATCATGTAAAAAATGTAGAAAAAATAGCC
AAAGAATTACAAATAGACGAATTTCACGCTCAGCTTAAGAGTGAAGAAAAACTACAAATCATTCAAAAATTTAAAAAAAC
TCTTTTTGTAGGAGATGGGATCAATGATGCGGCGGCTTTATCTGCTGCAAGTGTGAGTATGAGTTTTTCAAAGGCAAATG
AACTTGCTAAAAAAACAGGAGATTTTATCTTGATAAAAGATGATTTATCAGCGATTTTTAAATGTTTTAAACTTGCTAAA
AAAACACGCGGTATTATTAAGCTAAATCTTTTTTGGGCTTTTATTTATAATGTGCTTTGCATTCCTATCGCGGCAGGATT
TATACCTTTTATCTCTTTAAGTCCTCATATAGCAGCACTTGCAATGTGTTTTAGTTCTATTACTGTAGTGCTTAATTCTT
TAAGACTTAAAAGAATTTAA

Upstream 100 bases:

>100_bases
TGGAGCAAAAAATTTTAAGTTTAAATTTAGAAGAAAATCAAGTATCAAATTTTACAAAAGAATTTCAAGATTTAGGTTTT
GAGATCGTAGAGCGTTTATA

Downstream 100 bases:

>100_bases
AAATTTGATTTTTATTAATAATATATTATATATAATTAATATTACTAAAATATATTATTAAAAGAGTATAAATGCAACAA
AAATGTTTTTGCATAAGCAA

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIQNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGIVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGAVVLNGALRIKANKKAMDSTLEQIKNLVFEAGSIKSPLAN
LADQISKYFVGGIIFFAFLVFVFWVLKADLNTAFLHSCAVLLISCPCALGLATPIALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKEKLSVFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQICDLKGEGRVIVGSGIKYKEDNDNYLV
GSAQFLHENEIDTKESDIFFDSFKEYVRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKEQNLKTFILSGDHVKNVEKIA
KELQIDEFHAQLKSEEKLQIIQKFKKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRGIIKLNLFWAFIYNVLCIPIAAGFIPFISLSPHIAALAMCFSSITVVLNSLRLKRI

Sequences:

>Translated_699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIQNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGIVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGAVVLNGALRIKANKKAMDSTLEQIKNLVFEAGSIKSPLAN
LADQISKYFVGGIIFFAFLVFVFWVLKADLNTAFLHSCAVLLISCPCALGLATPIALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKEKLSVFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQICDLKGEGRVIVGSGIKYKEDNDNYLV
GSAQFLHENEIDTKESDIFFDSFKEYVRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKEQNLKTFILSGDHVKNVEKIA
KELQIDEFHAQLKSEEKLQIIQKFKKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRGIIKLNLFWAFIYNVLCIPIAAGFIPFISLSPHIAALAMCFSSITVVLNSLRLKRI
>Mature_699_residues
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIQNLGFEILEDEQSLNAYKAKK
HLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFFGIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSF
LVYLQIFKEEDLYFSGAMMIISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
GESIVADGIVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGAVVLNGALRIKANKKAMDSTLEQIKNLVFEAGSIKSPLAN
LADQISKYFVGGIIFFAFLVFVFWVLKADLNTAFLHSCAVLLISCPCALGLATPIALVVASANAAKNFILIKNPAALEKL
ALVKYAFFDKTGTLTKEKLSVFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQICDLKGEGRVIVGSGIKYKEDNDNYLV
GSAQFLHENEIDTKESDIFFDSFKEYVRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKEQNLKTFILSGDHVKNVEKIA
KELQIDEFHAQLKSEEKLQIIQKFKKTLFVGDGINDAAALSAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAK
KTRGIIKLNLFWAFIYNVLCIPIAAGFIPFISLSPHIAALAMCFSSITVVLNSLRLKRI

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=787, Percent_Identity=28.3354510800508, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI115529486, Length=820, Percent_Identity=27.3170731707317, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI55743073, Length=737, Percent_Identity=28.2225237449118, Blast_Score=192, Evalue=1e-48,
Organism=Escherichia coli, GI1786691, Length=729, Percent_Identity=29.2181069958848, Blast_Score=291, Evalue=1e-79,
Organism=Escherichia coli, GI1789879, Length=717, Percent_Identity=27.0571827057183, Blast_Score=203, Evalue=4e-53,
Organism=Escherichia coli, GI1786914, Length=506, Percent_Identity=22.9249011857708, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17556548, Length=791, Percent_Identity=27.8128950695322, Blast_Score=247, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6320475, Length=690, Percent_Identity=28.9855072463768, Blast_Score=227, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=684, Percent_Identity=26.6081871345029, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321430, Length=509, Percent_Identity=20.4322200392927, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325221, Length=515, Percent_Identity=20, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221329854, Length=518, Percent_Identity=30.8880308880309, Blast_Score=192, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 77744; Mature: 77744

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIQ
CCCCEEEECCEEEECHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHH
NLGFEILEDEQSLNAYKAKKHLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFF
HCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSFLVYLQIFKEEDLYFSGAMMI
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
ISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEC
GESIVADGIVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGAVVLNGALRIKANKKAMDST
CCCCHHCCEEEEECCCCCHHHHCCCEEEHHHCCCCCEECCEEEEECEEEEEECHHHHHHH
LEQIKNLVFEAGSIKSPLANLADQISKYFVGGIIFFAFLVFVFWVLKADLNTAFLHSCAV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLISCPCALGLATPIALVVASANAAKNFILIKNPAALEKLALVKYAFFDKTGTLTKEKLS
HHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHH
VFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQICDLKGEGRVIVGSGIKYKEDNDNYLV
HHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEECCCCCCEEE
GSAQFLHENEIDTKESDIFFDSFKEYVRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKE
ECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QNLKTFILSGDHVKNVEKIAKELQIDEFHAQLKSEEKLQIIQKFKKTLFVGDGINDAAAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHH
SAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAKKTRGIIKLNLFWAFIYNVLC
HHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHH
IPIAAGFIPFISLSPHIAALAMCFSSITVVLNSLRLKRI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEELRIKIGKMTCVNCSNAIERACKKIDGVKDASVSYVNSSGVFLLEDQEKRKDIIAKIQ
CCCCEEEECCEEEECHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHH
NLGFEILEDEQSLNAYKAKKHLELRKNLLLSIVLSVIIMYFEMFVKSSFSQNIQMALSFF
HCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFYCGRDFFSHAFLGLKSKNLDMNTLVALGTLSAFVYSFLVYLQIFKEEDLYFSGAMMI
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
ISFVLLGKYLESKAKFKAQDYQRILENIDTKKTKILLEDESIKEISSSFVKSGDVLLVKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEC
GESIVADGIVLLGSAELDMSFLNGEFLPVLKKEGDEVQAGAVVLNGALRIKANKKAMDST
CCCCHHCCEEEEECCCCCHHHHCCCEEEHHHCCCCCEECCEEEEECEEEEEECHHHHHHH
LEQIKNLVFEAGSIKSPLANLADQISKYFVGGIIFFAFLVFVFWVLKADLNTAFLHSCAV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLISCPCALGLATPIALVVASANAAKNFILIKNPAALEKLALVKYAFFDKTGTLTKEKLS
HHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHH
VFKHNLSKDDFDKLCQIESLSSHPIAKALHKDQICDLKGEGRVIVGSGIKYKEDNDNYLV
HHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEECCCCCCEEE
GSAQFLHENEIDTKESDIFFDSFKEYVRVYFAKNKKCLGGVLLSNALKDGAKELVLNLKE
ECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QNLKTFILSGDHVKNVEKIAKELQIDEFHAQLKSEEKLQIIQKFKKTLFVGDGINDAAAL
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHH
SAASVSMSFSKANELAKKTGDFILIKDDLSAIFKCFKLAKKTRGIIKLNLFWAFIYNVLC
HHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHH
IPIAAGFIPFISLSPHIAALAMCFSSITVVLNSLRLKRI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA