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The map label for this gene is copA [H]

Identifier: 57238030

GI number: 57238030

Start: 1206663

End: 1209014

Strand: Reverse

Name: copA [H]

Synonym: CJE1291

Alternate gene names: 57238030

Gene position: 1209014-1206663 (Counterclockwise)

Preceding gene: 57238033

Following gene: 57238029

Centisome position: 68.01

GC content: 30.65

Gene sequence:

>2352_bases
ATGAAATGTGAACATTGCAAACTTGATTATAAACAAGCCCAAATGATAGAGTATAAGGGTAAATTTTTTTGTTGTAAAGG
TTGTAAGAGCGTTTGGGAAATTTTACATGAAAGTGGATTAGATGAGTTTTATGAAAAGCTTGGAAATCAAACTTTAAGCC
CTGTAAATTTTCAAAATGAAATGAAAAATTATGATGAGTTTATCACTAAAACCAAAGAAGGATTTAGTGAAATTTATCTC
ATGATACACGGTATAGAATGTGCAGCTTGTGTGTGGCTTAATGAGAAAATTTTAACCAAACAAGAAGGAATTTTAGAACT
TGATATTAATCATTTAAACCATAAAGCACGCATTGTTTTTGATGAGCAAAGCATTTCTTTGGTGCAAATTTTAAGACTTA
TTGAAAGCATAGGCTATAAAGCGAGTGCTTATGATGCGAGCAAGGCTTCAAAAAAAGCGGATTTACTAAAAAGGGAATTT
TATTCTAAGCTTGTTGTGGCTATAGCTTGTGTGATGAATATCATGTGGATAGCAGTGGCAAAATACGCAGGATTTTTTAG
CGGTATGGATAAGGACACTAAGGATATTTTAAATTTTGCTGAATTTATCCTTTGTTCTCCTGTGCTTTTTTATACGGGAT
CTCATTTTTATAAAAGTGCTTTTAAAACTTTAAAAATGCATAGTTTAAATATGGATGTATTGGTGATTAGCGGAGCGAGT
TTGGCTTATGTTTATTCTTTATGGGCCATGTTTTTTAGGGTAGGGGAAGTGTATTTTGACTCTGTGGCGATGATAATTTG
CTTTGTTTTTATAGGTAAATATCTTGAGATGTTTAGCAAAAAGTGTGCTTTAGATACCATAGATGGGCTTAATGATTTTT
TACAAAATGAAGTTTTAGTTTTCAATGGTAAAGAATTTGTCTCTAAAGAAGTTCAAAAGGTTTGTTTAGGGGATAGAATT
TTGCTTAAAACTGGAGATAAAATTTTAATCGATGGGATTTGTAAAAGTGGTGAAATGAGTATGGATACTTCTTCTTTAAA
CGGAGAAAGTATTCCAAAACTCATACAAAAAGAAGATGAAATTTTTTCAGCTTGTATAGTGCTTGATGGAAGTGTGGAGT
ATGAAGCAACAAAGCTTTACAAGGATTCAAAACTCAGTCAAATTATCCAGCTTTTAGAACTTGCAAGTTCTAAAAAAGCA
AAACTTGAAAGTTTGGTCAATAGTCTTTTGGCTTATTTTTCTAGAACGGTTTTATTGATCGCTTTTATTTGTTTTGCTTT
TTGGTTTTTTTATAAAGAAGAGAGTTTTGAAATTTCTTTAGTCAATGCGATTGCAGTTTTGATTATCGCTTGTCCTTGTG
CTTTGGCTTTAGCAACGCCCGTGAGCAATCTTGTAGCTTTAGGTAGAGCTTTAAAAAAACATATTTTATTTAAAAGTTCT
AGCGTGATAGAAGATTTAAGCAAATGTGATTGTGTGGTATTTGATAAAACGGGTATTTTAACCAAAATAGAGCTTGAACT
TAAAGAGGTTTTTTTAGATAAAGCGCTTGATTTAAACGAGCTTTATAATTTTGTAAAACTTTCTAAACATCCTATCTCTC
AAAATATTGTGTTATATTTAAAGCAAAAAGGAGCTAAGGATTTAAATTTGGATTTTAAAAAGCATTCGAGTATTCAAGCT
AAAGGTTTAAGTGCTGAGTTAAATGAAGGGTTGCTTTTAGGCGGAAGTTCTAAATTTTTGCAAGAAAAGGGTATTGTGGC
TAAAGAATTTGATAATACGCATTTTATTTTTGCCAAGGAAGGTAAAATTTTAGCTTTTTTTGAGTTTGATAGTGTTTTAA
GAGAAGGTGCAAAAGAGCTTATCGCTTATCTTAAAAAAGAAAAGAAAGAATTAATGATACTCAGTGGCGATCATCAAAAA
GCAGTGGAAAAAATCGCTAAAAAGTTAGAAATTCAAAATTATCAAGCTTCTTGTTTGCCTGAAGATAAGATGAAAACTAT
AGAAAATTTAAGTAAAAATTACAAAGTTTTATTTGTAGGTGATGGGGTAAATGATGCACTAGCTTTAAAATACGCAAGTG
TTTCAATGACTTTAAGAGAAGGAAGTGATCTAGCTATAGAAAGTAGTGATGTTTTGCTTTTGAAAAATGACTTGCTTTCT
TTAAAAAAAGCCATCAAATTATCTAAAAACACCTTTAAAATTATCAAGCAAAATCTTGCTTTTTCTTTGTTTTATAATGC
TTGCACCATACCTTTGGCTTTTTTGGGTATGATAAATCCTTTATTTGCTGCTATTTCTATGTCTTTTAGTAGTATAATAG
TCGTTTTAAATGCTTTAAGGATTAAAGAATGA

Upstream 100 bases:

>100_bases
TTTAGCAGAATAATTTTTGTAAAATGTGATTTTAATAAAAAAATGCACTTTTTGTCAAATTTGTTTATAATTATAAAAAA
TATTTTTTTAAAGAATGATT

Downstream 100 bases:

>100_bases
ATAGTATAATCATGATGATGATAGGAGTTTCTATCTTAGCGTTTTTTATCATTTTGGCAACTTTGCTTTGGGGGATTAAA
AATAAGCAATTTGATGATGA

Product: ATPase P

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MKCEHCKLDYKQAQMIEYKGKFFCCKGCKSVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIICFVFIGKYLEMFSKKCALDTIDGLNDFLQNEVLVFNGKEFVSKEVQKVCLGDRI
LLKTGDKILIDGICKSGEMSMDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIQLLELASSKKA
KLESLVNSLLAYFSRTVLLIAFICFAFWFFYKEESFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDCVVFDKTGILTKIELELKEVFLDKALDLNELYNFVKLSKHPISQNIVLYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNEGLLLGGSSKFLQEKGIVAKEFDNTHFIFAKEGKILAFFEFDSVLREGAKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQASCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSIIVVLNALRIKE

Sequences:

>Translated_783_residues
MKCEHCKLDYKQAQMIEYKGKFFCCKGCKSVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIICFVFIGKYLEMFSKKCALDTIDGLNDFLQNEVLVFNGKEFVSKEVQKVCLGDRI
LLKTGDKILIDGICKSGEMSMDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIQLLELASSKKA
KLESLVNSLLAYFSRTVLLIAFICFAFWFFYKEESFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDCVVFDKTGILTKIELELKEVFLDKALDLNELYNFVKLSKHPISQNIVLYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNEGLLLGGSSKFLQEKGIVAKEFDNTHFIFAKEGKILAFFEFDSVLREGAKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQASCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSIIVVLNALRIKE
>Mature_783_residues
MKCEHCKLDYKQAQMIEYKGKFFCCKGCKSVWEILHESGLDEFYEKLGNQTLSPVNFQNEMKNYDEFITKTKEGFSEIYL
MIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVFDEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREF
YSKLVVAIACVMNIMWIAVAKYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
LAYVYSLWAMFFRVGEVYFDSVAMIICFVFIGKYLEMFSKKCALDTIDGLNDFLQNEVLVFNGKEFVSKEVQKVCLGDRI
LLKTGDKILIDGICKSGEMSMDTSSLNGESIPKLIQKEDEIFSACIVLDGSVEYEATKLYKDSKLSQIIQLLELASSKKA
KLESLVNSLLAYFSRTVLLIAFICFAFWFFYKEESFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
SVIEDLSKCDCVVFDKTGILTKIELELKEVFLDKALDLNELYNFVKLSKHPISQNIVLYLKQKGAKDLNLDFKKHSSIQA
KGLSAELNEGLLLGGSSKFLQEKGIVAKEFDNTHFIFAKEGKILAFFEFDSVLREGAKELIAYLKKEKKELMILSGDHQK
AVEKIAKKLEIQNYQASCLPEDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSIIVVLNALRIKE

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=775, Percent_Identity=28.5161290322581, Blast_Score=273, Evalue=6e-73,
Organism=Homo sapiens, GI115529486, Length=544, Percent_Identity=27.2058823529412, Blast_Score=189, Evalue=1e-47,
Organism=Homo sapiens, GI55743073, Length=811, Percent_Identity=24.2909987669544, Blast_Score=184, Evalue=4e-46,
Organism=Homo sapiens, GI48762687, Length=220, Percent_Identity=25, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI48762685, Length=220, Percent_Identity=25, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI48762691, Length=220, Percent_Identity=25, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI48762689, Length=220, Percent_Identity=25, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786691, Length=829, Percent_Identity=28.4680337756333, Blast_Score=318, Evalue=7e-88,
Organism=Escherichia coli, GI1789879, Length=710, Percent_Identity=23.6619718309859, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786914, Length=458, Percent_Identity=22.4890829694323, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17556548, Length=521, Percent_Identity=26.679462571977, Blast_Score=168, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320475, Length=757, Percent_Identity=27.6089828269485, Blast_Score=240, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6319772, Length=622, Percent_Identity=26.6881028938907, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321430, Length=243, Percent_Identity=25.5144032921811, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321271, Length=143, Percent_Identity=32.8671328671329, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325221, Length=243, Percent_Identity=25.1028806584362, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221329854, Length=556, Percent_Identity=26.2589928057554, Blast_Score=170, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 88166; Mature: 88166

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCEHCKLDYKQAQMIEYKGKFFCCKGCKSVWEILHESGLDEFYEKLGNQTLSPVNFQNE
CCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
MKNYDEFITKTKEGFSEIYLMIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECHHHHHCCCCEEEEEHHHCCCEEEEEE
DEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREFYSKLVVAIACVMNIMWIAVA
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
HHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCH
LAYVYSLWAMFFRVGEVYFDSVAMIICFVFIGKYLEMFSKKCALDTIDGLNDFLQNEVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEE
FNGKEFVSKEVQKVCLGDRILLKTGDKILIDGICKSGEMSMDTSSLNGESIPKLIQKEDE
ECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IFSACIVLDGSVEYEATKLYKDSKLSQIIQLLELASSKKAKLESLVNSLLAYFSRTVLLI
HHEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AFICFAFWFFYKEESFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SVIEDLSKCDCVVFDKTGILTKIELELKEVFLDKALDLNELYNFVKLSKHPISQNIVLYL
HHHHHHHHCCEEEEECCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEE
KQKGAKDLNLDFKKHSSIQAKGLSAELNEGLLLGGSSKFLQEKGIVAKEFDNTHFIFAKE
ECCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHCCCEEEECCCCEEEEEEC
GKILAFFEFDSVLREGAKELIAYLKKEKKELMILSGDHQKAVEKIAKKLEIQNYQASCLP
CCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
EDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
HHHHHHHHHHCCCCEEEEEECCCCCHHHEEEHHEEEEEECCCCCEEECCCEEEEHHHHHH
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSIIVVLNALR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKE
CCC
>Mature Secondary Structure
MKCEHCKLDYKQAQMIEYKGKFFCCKGCKSVWEILHESGLDEFYEKLGNQTLSPVNFQNE
CCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHH
MKNYDEFITKTKEGFSEIYLMIHGIECAACVWLNEKILTKQEGILELDINHLNHKARIVF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECHHHHHCCCCEEEEEHHHCCCEEEEEE
DEQSISLVQILRLIESIGYKASAYDASKASKKADLLKREFYSKLVVAIACVMNIMWIAVA
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYAGFFSGMDKDTKDILNFAEFILCSPVLFYTGSHFYKSAFKTLKMHSLNMDVLVISGAS
HHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCH
LAYVYSLWAMFFRVGEVYFDSVAMIICFVFIGKYLEMFSKKCALDTIDGLNDFLQNEVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEE
FNGKEFVSKEVQKVCLGDRILLKTGDKILIDGICKSGEMSMDTSSLNGESIPKLIQKEDE
ECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IFSACIVLDGSVEYEATKLYKDSKLSQIIQLLELASSKKAKLESLVNSLLAYFSRTVLLI
HHEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AFICFAFWFFYKEESFEISLVNAIAVLIIACPCALALATPVSNLVALGRALKKHILFKSS
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SVIEDLSKCDCVVFDKTGILTKIELELKEVFLDKALDLNELYNFVKLSKHPISQNIVLYL
HHHHHHHHCCEEEEECCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEE
KQKGAKDLNLDFKKHSSIQAKGLSAELNEGLLLGGSSKFLQEKGIVAKEFDNTHFIFAKE
ECCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHCCCEEEECCCCEEEEEEC
GKILAFFEFDSVLREGAKELIAYLKKEKKELMILSGDHQKAVEKIAKKLEIQNYQASCLP
CCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
EDKMKTIENLSKNYKVLFVGDGVNDALALKYASVSMTLREGSDLAIESSDVLLLKNDLLS
HHHHHHHHHHCCCCEEEEEECCCCCHHHEEEHHEEEEEECCCCCEEECCCEEEEHHHHHH
LKKAIKLSKNTFKIIKQNLAFSLFYNACTIPLAFLGMINPLFAAISMSFSSIIVVLNALR
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA