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The map label for this gene is thiD [H]

Identifier: 57237964

GI number: 57237964

Start: 1139723

End: 1140535

Strand: Reverse

Name: thiD [H]

Synonym: CJE1225

Alternate gene names: 57237964

Gene position: 1140535-1139723 (Counterclockwise)

Preceding gene: 57237965

Following gene: 57237963

Centisome position: 64.15

GC content: 35.3

Gene sequence:

>813_bases
ATGAAAGCAAAAGGAAGTGAACTTATACCTGTTTTAACTATAGCAGGGAGTGATTGTAGTGGTGGAGCAGGGATACAAGC
CGATCTTAAAACCTTTAGTGCACACAATCTTTTTGGTATGAGTGTGGTTTTAAGTGTGGTAGCTGAAAATACCGCAAGGG
TGATTTCTGTACACGATATACCTACTCAAAGCGTGGATGAACAAATGCTTGCCGTGTTTGAAGATATAGTGCCAAAGGCA
ACTAAAATCGGAATGATAGGTTCTTGTGAATTAATGAGCTGTGTAGCTAAAAATTTAAGCGAGTTTAAACCTCAAAATGT
AGTTATTGATCCTGTAATGTTTGCCAAAAATGGCTATGCTTTAATGCCGCAAGAAAATTGTGATTTTTTCAAACAAACTA
TAATAAAATTTGCAGACATTCTTACTCCTAATATTCCTGAAGCAGAGTTTTTATGTGGTTTTAAGATCGCTAATGAAGAG
CAGATGATAAAAGCAGCTAAGCATTTATGCAGCTTGGGGGTTAAGGCAGTTTTACTTAAAGGCGGACATAGTGAAGCAAA
TGCCAATGATGTGCTTTATAATGGAAAAGAAATTTATATTTTAAAAGGCGAACGCATAGAAACTAAAAATACTCACGGTA
CAGGTTGTACGCTTTCTTCGGCTATTGCTAGTAATTTAGCTAAAGGCAAGGATTTATTTCACGCTGTTAGTGAAGCTAAA
GAGTATGTAAGAAATGCGATTTATTATTCACTTAATCTTGGAAAAGGTTGTGGTCCTACAAATCATTTTTTCAAGTTTCT
AGATGAAAAATAA

Upstream 100 bases:

>100_bases
TTTTTCATGCTTTGATTGTAGCTTTTGCAAAACAGAGTTTTAAAGGACAAAAATTAAGCCCTAAGGGTGAAGAATGGATC
AAAATTTTAAAGGAAGATTT

Downstream 100 bases:

>100_bases
ATTAGATCTTAGCCTTTATTTGGTTGCTACTAAGGGAAATAAAAGCGAGGAGTGTTTTTTAAATACTTTAGAAAATGCTA
TAAAAGGCGGAGTAAGTATC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIIKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGVKAVLLKGGHSEANANDVLYNGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK

Sequences:

>Translated_270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIIKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGVKAVLLKGGHSEANANDVLYNGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
>Mature_270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIIKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGVKAVLLKGGHSEANANDVLYNGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=40.6844106463878, Blast_Score=192, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325378, Length=278, Percent_Identity=36.3309352517986, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324997, Length=279, Percent_Identity=36.9175627240143, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=36.7272727272727, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29200; Mature: 29200

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDI
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECC
PTQSVDEQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYA
CCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCEE
LMPQENCDFFKQTIIKFADILTPNIPEAEFLCGFKIANEEQMIKAAKHLCSLGVKAVLLK
ECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECEEECCHHHHHHHHHHHHHHCHHEEEEE
GGHSEANANDVLYNGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
CCCCCCCCCCEEECCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
HHHHHHEEEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDI
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECC
PTQSVDEQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYA
CCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCEE
LMPQENCDFFKQTIIKFADILTPNIPEAEFLCGFKIANEEQMIKAAKHLCSLGVKAVLLK
ECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECEEECCHHHHHHHHHHHHHHCHHEEEEE
GGHSEANANDVLYNGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
CCCCCCCCCCEEECCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
HHHHHHEEEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]