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The map label for this gene is apt

Identifier: 57237755

GI number: 57237755

Start: 939239

End: 939787

Strand: Direct

Name: apt

Synonym: CJE1005

Alternate gene names: 57237755

Gene position: 939239-939787 (Clockwise)

Preceding gene: 57237754

Following gene: 57237756

Centisome position: 52.83

GC content: 30.05

Gene sequence:

>549_bases
ATGATAAAACTAACACAAGAAGAACAAAAATACCTGCTTGATAGCATTAGGATTATTCCTGATTTTCCAAAAAAAGGAAT
TATTTTTAGAGATATTACCACTCTACTAAATAACAAAGAGGCTTTAAATTTTCTACTTAAACATTTAAAAGAACGCTACA
AAGATTACAATCTAGACTTCATAGCAGGAACAGAAAGCAGAGGATTTATCTTTGCATCTATGATTTGTGCAAAACTTAAT
CTTCCTTTTGTGCCTATTAGAAAACCTGGAAAACTCCCTTTTGAAACCTTTAGCTGCGAATACGATCTTGAATATGGCAG
CGATAAAGTAGAACTTCATAAAGATGCATTTAAAAATATTCAAAATGCAAGAGTTTTACTTGTAGATGATTTAATAGCAA
CTGGCGGAACAGCTATAGCTTCATATGAACTCATTCAAAAAGCTGGAGCAAAATGTGTTGAAGCTTGTTTTTTAATGAAT
CTTAAAGATTTAAATGGAGCAAATAAACTTGAAAAACTTACTTCAGTTTATAGTGTTTTAGAAATTTAA

Upstream 100 bases:

>100_bases
ACCTTACATCTTTAAGAACCAGAAATTCTCAATATCGCTTGGAAAATGACAAACTAAGACAAAGAATTAAAGAATTAGAA
GCAAAAATTGAGGCATTATT

Downstream 100 bases:

>100_bases
AACTATAGAAAGGTACAAATGGAAGAATTTTTAAAAAATTTACTTTACCAATACAAAGATCTAGCTTATATTATTATTTT
TTTATGGTGCATTTTAGAAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDFIAGTESRGFIFASMICAKLN
LPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNIQNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMN
LKDLNGANKLEKLTSVYSVLEI

Sequences:

>Translated_182_residues
MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDFIAGTESRGFIFASMICAKLN
LPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNIQNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMN
LKDLNGANKLEKLTSVYSVLEI
>Mature_182_residues
MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDFIAGTESRGFIFASMICAKLN
LPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNIQNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMN
LKDLNGANKLEKLTSVYSVLEI

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=40.9356725146199, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI71773201, Length=136, Percent_Identity=41.9117647058824, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1786675, Length=168, Percent_Identity=48.2142857142857, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=167, Percent_Identity=46.1077844311377, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=155, Percent_Identity=41.9354838709677, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=184, Percent_Identity=31.5217391304348, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=41.5204678362573, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CAMJ8 (A8FLX6)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001482440.1
- ProteinModelPortal:   A8FLX6
- SMR:   A8FLX6
- STRING:   A8FLX6
- GeneID:   5618502
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_0864
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   CJEJ407148:C8J_0864-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20689; Mature: 20689

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDF
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
IAGTESRGFIFASMICAKLNLPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNI
EECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCEEECEEEECCCCCCHHHHHHHHHHCC
QNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMNLKDLNGANKLEKLTSVYSVL
CCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EI
CC
>Mature Secondary Structure
MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDF
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEE
IAGTESRGFIFASMICAKLNLPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNI
EECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCEEECEEEECCCCCCHHHHHHHHHHCC
QNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMNLKDLNGANKLEKLTSVYSVL
CCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA