Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 57237697

GI number: 57237697

Start: 880014

End: 880862

Strand: Direct

Name: lepB [H]

Synonym: CJE0943

Alternate gene names: 57237697

Gene position: 880014-880862 (Clockwise)

Preceding gene: 57237696

Following gene: 57237701

Centisome position: 49.5

GC content: 32.39

Gene sequence:

>849_bases
ATGGAAATTTTAAAGAAATTATATAAATTTTCACAGTCTTGGACTGGAACTGTAGTTATTGTTCTTTTGGTGATTTTTTT
CTTTATACAAGCTTTTGTTATTCCTTCTGGTTCTATGAAAAACACCTTATTGGTAGGGGATTTTTTATTTGTTAAAAAAT
TTAGCTATGGTATCCCAACTCCTCATATTCCTTGGTTGGAAATTCCTGTTTTGCCAGATTTCAATAAAGATGGGCATTTG
ATAAAAGCACAAGGGTCACAAAGAGGAGATATAGTTGTTTTTAGAAATCCTAGAAATGAAAAAGAACACTTTGTAAAGCG
TTGTGTAGGCACAGGAGGAGATAGGATAGTTTATGCAAATAAAACACTTTATGTAAGAATGCATGAGGGTGATGAATTTA
TGAAAGAACATTATCCGAATGATCTTGTTACTCTTGGAGGGCAAATTTATGTAAAAGAACCTTATAAACAAAAAGGTATT
CATTATGATCCAAAAAAAGATATAGAAAGCGATATTTTACGCTTTCTTAGCATAGGTGATTTTGCTATGTCTCCAACTTA
TATTAAAGAACTTGGAAATCATATAGGTTTTAGCGGCGGAAATGCTTATGTTTTTGATGTGCCTGAAAATGAGTATTTCA
TGATGGGTGATAATCGCGATTATTCTTATGATAGTCGTTTTTGGGGTTCTGTTCCTTATAGGTTGATAGTAGGTAAACCT
TGGTTTGTATATTTCTCTTGGGATAAAGATAAAAATGTTCGCTGGGAAAGGATAGGGCGTTTTGTTGATACCTTGGAAAA
TGATGAACAATATATCCATGATCATGATGATGAGGATAAATTAAGCTAA

Upstream 100 bases:

>100_bases
TATAACTCCTGTTCCAGGTGGAGTAGGTCCTATGACTATAGCCATGCTTTTAGAAAACACAGTTAAATCTGCTAAAAATA
GACTTAATTAGGGAAAATCT

Downstream 100 bases:

>100_bases
TGTTTGTGAAAAACACAAACATTATATTTTTAAAAGCGTGATTTCATCACCTTTTTTTAATTTGCTTATATTTTCTTCAC
TTATAAGTAAAAATTCACTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MEILKKLYKFSQSWTGTVVIVLLVIFFFIQAFVIPSGSMKNTLLVGDFLFVKKFSYGIPTPHIPWLEIPVLPDFNKDGHL
IKAQGSQRGDIVVFRNPRNEKEHFVKRCVGTGGDRIVYANKTLYVRMHEGDEFMKEHYPNDLVTLGGQIYVKEPYKQKGI
HYDPKKDIESDILRFLSIGDFAMSPTYIKELGNHIGFSGGNAYVFDVPENEYFMMGDNRDYSYDSRFWGSVPYRLIVGKP
WFVYFSWDKDKNVRWERIGRFVDTLENDEQYIHDHDDEDKLS

Sequences:

>Translated_282_residues
MEILKKLYKFSQSWTGTVVIVLLVIFFFIQAFVIPSGSMKNTLLVGDFLFVKKFSYGIPTPHIPWLEIPVLPDFNKDGHL
IKAQGSQRGDIVVFRNPRNEKEHFVKRCVGTGGDRIVYANKTLYVRMHEGDEFMKEHYPNDLVTLGGQIYVKEPYKQKGI
HYDPKKDIESDILRFLSIGDFAMSPTYIKELGNHIGFSGGNAYVFDVPENEYFMMGDNRDYSYDSRFWGSVPYRLIVGKP
WFVYFSWDKDKNVRWERIGRFVDTLENDEQYIHDHDDEDKLS
>Mature_282_residues
MEILKKLYKFSQSWTGTVVIVLLVIFFFIQAFVIPSGSMKNTLLVGDFLFVKKFSYGIPTPHIPWLEIPVLPDFNKDGHL
IKAQGSQRGDIVVFRNPRNEKEHFVKRCVGTGGDRIVYANKTLYVRMHEGDEFMKEHYPNDLVTLGGQIYVKEPYKQKGI
HYDPKKDIESDILRFLSIGDFAMSPTYIKELGNHIGFSGGNAYVFDVPENEYFMMGDNRDYSYDSRFWGSVPYRLIVGKP
WFVYFSWDKDKNVRWERIGRFVDTLENDEQYIHDHDDEDKLS

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=270, Percent_Identity=33.7037037037037, Blast_Score=121, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 32972; Mature: 32972

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILKKLYKFSQSWTGTVVIVLLVIFFFIQAFVIPSGSMKNTLLVGDFLFVKKFSYGIPT
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCC
PHIPWLEIPVLPDFNKDGHLIKAQGSQRGDIVVFRNPRNEKEHFVKRCVGTGGDRIVYAN
CCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEC
KTLYVRMHEGDEFMKEHYPNDLVTLGGQIYVKEPYKQKGIHYDPKKDIESDILRFLSIGD
CEEEEEECCCHHHHHHHCCCCEEEECCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCC
FAMSPTYIKELGNHIGFSGGNAYVFDVPENEYFMMGDNRDYSYDSRFWGSVPYRLIVGKP
CCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCE
WFVYFSWDKDKNVRWERIGRFVDTLENDEQYIHDHDDEDKLS
EEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MEILKKLYKFSQSWTGTVVIVLLVIFFFIQAFVIPSGSMKNTLLVGDFLFVKKFSYGIPT
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCCC
PHIPWLEIPVLPDFNKDGHLIKAQGSQRGDIVVFRNPRNEKEHFVKRCVGTGGDRIVYAN
CCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEC
KTLYVRMHEGDEFMKEHYPNDLVTLGGQIYVKEPYKQKGIHYDPKKDIESDILRFLSIGD
CEEEEEECCCHHHHHHHCCCCEEEECCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCC
FAMSPTYIKELGNHIGFSGGNAYVFDVPENEYFMMGDNRDYSYDSRFWGSVPYRLIVGKP
CCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCE
WFVYFSWDKDKNVRWERIGRFVDTLENDEQYIHDHDDEDKLS
EEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]