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The map label for this gene is pyrD [H]

Identifier: 57237649

GI number: 57237649

Start: 834867

End: 835925

Strand: Direct

Name: pyrD [H]

Synonym: CJE0895

Alternate gene names: 57237649

Gene position: 834867-835925 (Clockwise)

Preceding gene: 57237648

Following gene: 57237650

Centisome position: 46.96

GC content: 30.78

Gene sequence:

>1059_bases
ATGGCTTATGAAATGATAAAACCTTTACTTTTTAAGTTAAACCCTGAGCATGTACATACTTTGGTTGAATATAGCTTAAG
AGCTTTAAGTGCTAGTTTTCCAGGATCTTTAAGTTTTTTAGCACATAAATATATAGTTGATGATGAGAGTTTAAGGCAAA
ATTTACTTGGACTTGATTTTAATAATCCTGTGGGTTTAGCAGGGGGCTTTGATAAAAATGCCACTATGATAAGACCTTTG
AGTGCTTTAGGATTTGGCTTTTTGGAAGTGGGAACTTTTACTCCAAAACCTCAAGAAGGCAATGAAAAACCACGCCTATT
TAGACTTGTAAAACAAGAAAGTATACAAAATGCTATGGGTTTTAACAACGAAGGTGCTGAAAAGATCGCTTTAAGACTTG
TAAAAACTTATCCTTTCGTTTTACCTTTAGGGGTAAATATAGGGAAAAATAAAATCACTCCAAATGACAAAGCTTTGGAG
GATTATTTTACTTTATTTAGAGATTTTAAGGATTTGTGTGATTATTTTATCGTTAATATCTCATCTCCTAATACTAAAAA
TTTAAGAGAGTTACAAAATGATGATTTTTTAAATACCTTGCTTGAAGAAGCCAAAAAAATTACTTCTAAGCCTATTTTGA
TAAAAATTGCTCCTGATATGAAAATAGATGATGCTTTAAATTTATGTGAAAATGCTATTAAAAAAGGTGCAGATGGGTTT
ATATTAGCCAATACTAGTGTTGATTATAGCTTACTAGATAATAATCGTACTTTTGGTGGTATTAGTGGAAGGTTGATTAC
AGAAAAAAGTGGTATTTTTTTCAAAGAAGTAGCTAAAATTCTTTTTGGCAAAACCTTGCTTATTGCAAGTGGAGGGATTG
ATAGTGCTGATATTGCTTATGAGCGTATTAAAAATGGGGCTAATTTGGTGCAAGTTTATACAGCTTTGATTTTTAAAGGT
CCTTCTTTGGTAAAAAATATCAATCAAAATCTTATAGAGCTTTTAAGAAAAGATGGTTTTTTACACATTAGCGAAGCTGT
TGGGGTAAATTTAAAATGA

Upstream 100 bases:

>100_bases
CTTTTACAAACTTGTTCTTTATATCAAAAATTTAAAAGCAAAGAAAAAACAAAGCCTAGCTTTAGTTAATTTTAGTTAGA
ATTTCAAAAAGGATTAAAAA

Downstream 100 bases:

>100_bases
TTGCTTATGAAAAAATTCAATTAAAAAACAAGCTTGAAGTTTATGCTTTGCCTGTAAATAAAAATAGCGATGTGATTAGC
GTTGATATTTTTTATAAAGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MAYEMIKPLLFKLNPEHVHTLVEYSLRALSASFPGSLSFLAHKYIVDDESLRQNLLGLDFNNPVGLAGGFDKNATMIRPL
SALGFGFLEVGTFTPKPQEGNEKPRLFRLVKQESIQNAMGFNNEGAEKIALRLVKTYPFVLPLGVNIGKNKITPNDKALE
DYFTLFRDFKDLCDYFIVNISSPNTKNLRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALNLCENAIKKGADGF
ILANTSVDYSLLDNNRTFGGISGRLITEKSGIFFKEVAKILFGKTLLIASGGIDSADIAYERIKNGANLVQVYTALIFKG
PSLVKNINQNLIELLRKDGFLHISEAVGVNLK

Sequences:

>Translated_352_residues
MAYEMIKPLLFKLNPEHVHTLVEYSLRALSASFPGSLSFLAHKYIVDDESLRQNLLGLDFNNPVGLAGGFDKNATMIRPL
SALGFGFLEVGTFTPKPQEGNEKPRLFRLVKQESIQNAMGFNNEGAEKIALRLVKTYPFVLPLGVNIGKNKITPNDKALE
DYFTLFRDFKDLCDYFIVNISSPNTKNLRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALNLCENAIKKGADGF
ILANTSVDYSLLDNNRTFGGISGRLITEKSGIFFKEVAKILFGKTLLIASGGIDSADIAYERIKNGANLVQVYTALIFKG
PSLVKNINQNLIELLRKDGFLHISEAVGVNLK
>Mature_351_residues
AYEMIKPLLFKLNPEHVHTLVEYSLRALSASFPGSLSFLAHKYIVDDESLRQNLLGLDFNNPVGLAGGFDKNATMIRPLS
ALGFGFLEVGTFTPKPQEGNEKPRLFRLVKQESIQNAMGFNNEGAEKIALRLVKTYPFVLPLGVNIGKNKITPNDKALED
YFTLFRDFKDLCDYFIVNISSPNTKNLRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALNLCENAIKKGADGFI
LANTSVDYSLLDNNRTFGGISGRLITEKSGIFFKEVAKILFGKTLLIASGGIDSADIAYERIKNGANLVQVYTALIFKGP
SLVKNINQNLIELLRKDGFLHISEAVGVNLK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=369, Percent_Identity=36.5853658536585, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1787177, Length=339, Percent_Identity=38.6430678466077, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17509475, Length=367, Percent_Identity=35.9673024523161, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281361352, Length=364, Percent_Identity=37.3626373626374, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI17137316, Length=364, Percent_Identity=37.3626373626374, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39081; Mature: 38950

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYEMIKPLLFKLNPEHVHTLVEYSLRALSASFPGSLSFLAHKYIVDDESLRQNLLGLDF
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCC
NNPVGLAGGFDKNATMIRPLSALGFGFLEVGTFTPKPQEGNEKPRLFRLVKQESIQNAMG
CCCCCCCCCCCCCCHHCCCHHHHCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
FNNEGAEKIALRLVKTYPFVLPLGVNIGKNKITPNDKALEDYFTLFRDFKDLCDYFIVNI
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEC
SSPNTKNLRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALNLCENAIKKGADGF
CCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
ILANTSVDYSLLDNNRTFGGISGRLITEKSGIFFKEVAKILFGKTLLIASGGIDSADIAY
EEEECCCCEEEECCCCEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHH
ERIKNGANLVQVYTALIFKGPSLVKNINQNLIELLRKDGFLHISEAVGVNLK
HHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
>Mature Secondary Structure 
AYEMIKPLLFKLNPEHVHTLVEYSLRALSASFPGSLSFLAHKYIVDDESLRQNLLGLDF
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCC
NNPVGLAGGFDKNATMIRPLSALGFGFLEVGTFTPKPQEGNEKPRLFRLVKQESIQNAMG
CCCCCCCCCCCCCCHHCCCHHHHCCCHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
FNNEGAEKIALRLVKTYPFVLPLGVNIGKNKITPNDKALEDYFTLFRDFKDLCDYFIVNI
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEC
SSPNTKNLRELQNDDFLNTLLEEAKKITSKPILIKIAPDMKIDDALNLCENAIKKGADGF
CCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
ILANTSVDYSLLDNNRTFGGISGRLITEKSGIFFKEVAKILFGKTLLIASGGIDSADIAY
EEEECCCCEEEECCCCEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHH
ERIKNGANLVQVYTALIFKGPSLVKNINQNLIELLRKDGFLHISEAVGVNLK
HHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA