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The map label for this gene is uvrD [H]

Identifier: 57237622

GI number: 57237622

Start: 806953

End: 808983

Strand: Direct

Name: uvrD [H]

Synonym: CJE0868

Alternate gene names: 57237622

Gene position: 806953-808983 (Clockwise)

Preceding gene: 57237606

Following gene: 57237623

Centisome position: 45.39

GC content: 30.03

Gene sequence:

>2031_bases
ATGCCACTTTCAAAATTAAATAATGAACAATATCTTGCTGCTACTGCTGATTTTGGACACAATCTTGTTATTGCAAGTGC
AGGGACGGGAAAAACTTCTACTATTGTTGCAAGAATTTCTTATCTTTTAAGCAAGGGAGTGGCACCTCAAAAAATTATGC
TTTTGACTTTCACAAATAAAGCCAGTAAAGAAATGATAGGGCGTTTAGGGAAATTTTTTGATAAAAATATTACCAGTAAA
ATACTTGCAGGAACTTTTCATAGTACGGCTTATACCTTACTTAGAAATGCGGATAAAAATATAGCCTTAAAGCAAGCAAG
CGAGTTAAAAACTCTACTTAAAAGTGTCTATGAAAAAAGAACTTTTAGGCATTTAAGTGATATAAAACCTTATCAATCAA
GTTATTTATATGATCTTTATTCTTTGTTTCAAAACAAAGCGCACAATCAAGATTTTTATACTTGGTTTTGCCAAAACTAC
GAAGATCAAAGTATTTATGCTGAAATTTATGAAGATATTTTAAAAGAATATGATAATGAAAAAAAGCGTTTTAATTATGT
AGATTTTAATGACTTGCTTATCAATCTAAAAGATCTTTTAAAAGAAGAAAAATATGAATTTGATGAAATTTTAGTAGATG
AATATCAAGACACAAATACTTTGCAAAGTTCCTTAATAGAGGCTTTTCATAGTAAAAGTTTGTTTTGCGTAGGGGATTAT
GATCAAAGTATTTATGCTTTTAATGGAGCGGATATTAATATCATAGGTGGGTTTAAAGATCGTTTTAAAGATGCAAAAAT
TTTTTCTTTAAATAAAAACTACCGTTCATCAAGAAGTATTTTAGCTTTGGCTAATAAAGTGATTTTAAATAACGAAAGAT
TATACCCAAAAGAACTTATTGTTACAAGAAATGATGAATTTAAAGCCCCATCTTTGCTTACTTTTGAAGAATTATTTGAT
CAGTATCAAAATATAGCCAAAATGATACTTACAAGCGGAGTAAGTTTGGAAGAAATTGCCGTGATTTTTCGCAACAACTC
AAGTGCTGATGGGGTTGAAGTAGCTTTAAGGGAGCAGGGCATTGCAAGTGTGAGAAAGGGAAGTGGAAGTTTTTTTGAAA
GTTTAGAAGTTAAAGCTTTTAGCTCTATGCTTGCTCTTGTGGTAAATCCTAAGGATATTATGGCTTTTATTCATTTGGTT
CAATACACCAAAGGTGTGGGTGGAGTTTTAGCAAAAGAAATTTTTGACGCACTTTTAAAATTAGGGCATGGAAATTTAAT
AAAAGGTTTTTTAGATCCTGATAAAAATGTAAATTTGCAAAATCATCAAAAAAGAAATTATCAACTTGGGCTTTTTGCGG
ATTTAGAAGAATTAGCCAGCGAAACTCGTTTTAAATTTGAGAGTGAATTTGATGCACATCCTATTTTAAAACTTTCAAAA
ATCAATGATTTATGTGCTAGAAATTTAGAAAAAATTTATCTTTTTTTAAAAAAAGCTATGGAAATAAAACATTCTTTGAC
TTTGGTAAATTTAATTTGTGAAAATTCTTTTTATAGAGAAATTTGTGAAGAACTTGCAACCAAAAGAGCAACAAATAAAG
CAGGACAGGTGGATTTATTAAGAAAGAGTGAAAATTTAGAAAAAATAGAAACAAAATTCAATGTCTTAAAAGAGCTTACA
AAAAATTATAGCGATATTTATAAGTATTATAATTTTCTAACTTTAGGTGCAAGCGAAATGAGTAGTGGCAAAGGAGTTAA
TTTGCTTAGTGTGCATGCAAGTAAGGGCTTGGAATTTGATCTTGTTTTTGTGATTGATCTTGCACAAGGTCGCTTTCCTA
ATCAAAAGCTTATGGGAATGGGTGGAAGCTTAGAAGAAGAAAGAAGGCTTTTTTATGTTGCAGTAACTAGGGCAAAAAAT
ATACTTTATTTAAGCTATGCTAAATATGATAAAAATAAAAAAACTTCTTTCGCCCCTTCTCGTTTTCTTATAGAAGCAGG
GCTTTGCAAGGGAGAGTTAACTATAGATTGA

Upstream 100 bases:

>100_bases
ATAATTTTAGCATTGTACTATAATCTAATATAAAGTAATTTTAAATTTTTATATTTTTAAGTAATTTTTTTTTATAATTT
TAACTTTTATAAGGAAAATA

Downstream 100 bases:

>100_bases
TAAAATTTCCTTTATATTATTATAAAGAAAGGTTTATTTTATGAAAAAAATATTAATTTTAAGTTTAGCAGCAGCAAGTT
TTTTAAATGCTGAAATTTTA

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MPLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNKASKEMIGRLGKFFDKNITSK
ILAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKRTFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNY
EDQSIYAEIYEDILKEYDNEKKRFNYVDFNDLLINLKDLLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDY
DQSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELIVTRNDEFKAPSLLTFEELFD
QYQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQGIASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLV
QYTKGVGGVLAKEIFDALLKLGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSK
INDLCARNLEKIYLFLKKAMEIKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLLRKSENLEKIETKFNVLKELT
KNYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFDLVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKN
ILYLSYAKYDKNKKTSFAPSRFLIEAGLCKGELTID

Sequences:

>Translated_676_residues
MPLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNKASKEMIGRLGKFFDKNITSK
ILAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKRTFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNY
EDQSIYAEIYEDILKEYDNEKKRFNYVDFNDLLINLKDLLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDY
DQSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELIVTRNDEFKAPSLLTFEELFD
QYQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQGIASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLV
QYTKGVGGVLAKEIFDALLKLGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSK
INDLCARNLEKIYLFLKKAMEIKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLLRKSENLEKIETKFNVLKELT
KNYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFDLVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKN
ILYLSYAKYDKNKKTSFAPSRFLIEAGLCKGELTID
>Mature_675_residues
PLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNKASKEMIGRLGKFFDKNITSKI
LAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKRTFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNYE
DQSIYAEIYEDILKEYDNEKKRFNYVDFNDLLINLKDLLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDYD
QSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELIVTRNDEFKAPSLLTFEELFDQ
YQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQGIASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLVQ
YTKGVGGVLAKEIFDALLKLGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSKI
NDLCARNLEKIYLFLKKAMEIKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLLRKSENLEKIETKFNVLKELTK
NYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFDLVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKNI
LYLSYAKYDKNKKTSFAPSRFLIEAGLCKGELTID

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=702, Percent_Identity=28.7749287749288, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI48994965, Length=695, Percent_Identity=26.4748201438849, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1787196, Length=370, Percent_Identity=27.8378378378378, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=470, Percent_Identity=29.1489361702128, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324477, Length=393, Percent_Identity=24.4274809160305, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77107; Mature: 76976

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNK
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCH
ASKEMIGRLGKFFDKNITSKILAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
TFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNYEDQSIYAEIYEDILKEYDNE
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHCCH
KKRFNYVDFNDLLINLKDLLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDY
HHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECC
DQSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELI
CCCEEEECCCCEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHEE
VTRNDEFKAPSLLTFEELFDQYQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQG
EECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHHHC
IASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLVQYTKGVGGVLAKEIFDALLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSK
CCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEHHH
INDLCARNLEKIYLFLKKAMEIKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHH
RKSENLEKIETKFNVLKELTKNYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFD
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCCCEEEEEECCCCCCEE
LVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKNILYLSYAKYDKNKKTSFAPS
EEEEEEECCCCCCCHHHHCCCCCCCHHCEEEEEEEECCCCEEEEEEEHHCCCCCCCCCCH
RFLIEAGLCKGELTID
HHHHCCCCCCCCEECC
>Mature Secondary Structure 
PLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNK
CCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCH
ASKEMIGRLGKFFDKNITSKILAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
TFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNYEDQSIYAEIYEDILKEYDNE
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHCCH
KKRFNYVDFNDLLINLKDLLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDY
HHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECC
DQSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELI
CCCEEEECCCCEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHEE
VTRNDEFKAPSLLTFEELFDQYQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQG
EECCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCHHHHHHHHC
IASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLVQYTKGVGGVLAKEIFDALLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSK
CCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEHHH
INDLCARNLEKIYLFLKKAMEIKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHH
RKSENLEKIETKFNVLKELTKNYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFD
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCCCEEEEEECCCCCCEE
LVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKNILYLSYAKYDKNKKTSFAPS
EEEEEEECCCCCCCHHHHCCCCCCCHHCEEEEEEEECCCCEEEEEEEHHCCCCCCCCCCH
RFLIEAGLCKGELTID
HHHHCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]