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The map label for this gene is purE [H]

Identifier: 57237005

GI number: 57237005

Start: 739218

End: 739712

Strand: Direct

Name: purE [H]

Synonym: CJE0802

Alternate gene names: 57237005

Gene position: 739218-739712 (Clockwise)

Preceding gene: 57237004

Following gene: 57237006

Centisome position: 41.58

GC content: 35.15

Gene sequence:

>495_bases
ATGAATTTTGTTTCTATTTTAATGGGAAGCAAGAGTGATTATGAGACTATGAAAGAGGCTGCTAAAACTTTAGAAAGTTT
TGGGGTAAAGTATGAACTTATTATCTCATCAGCTCATCGTAGTCCAAAAAGAACAAAAGAGTATATTGCAAATGCTGAAG
AAAAAGGTGTGAAAGTTTTTATAGCAGCAGCTGGAATGGCAGCGCATTTAGCTGGAGCTGTTGCAGCTTATACAACAAAA
CCTGTTTTGGGAGTGCCTATGTCAGGAAGCAATCTTGCAAGTATGGATTCTTTGTTTTCTACGGTGCAAATGCCTAGTGG
AATTCCTGTAGGAACTTTAGCTATTGGTAAGGCTGGAGCAATCAATGCTGCTTATTTGGCTATGCAAATTTTAGCTATTT
ATGATGTTGATTTAGCACAAAAGCTTAAAGAAGATCGTCTTGAAAAAGAAAAAAAACTTGTATCTGATTCAAAAGAAGTA
GAAGTTTTATTATAA

Upstream 100 bases:

>100_bases
AAACAATAAGGAATTTAGCGAAATTCATAGTGGCAATGAACATGAAATCCAATTACCAAATAAAATCAGTGCATTAAGTT
TTTTAAGAAAGGAAATATAG

Downstream 100 bases:

>100_bases
GGGATAAAAATGCAAACCTATCTTGAACTTGAAGAATTTTGTAAACTTGTGCATTTAAATGAAGATGTGGTTAAAGGTAT
GATGGCTAATGGGGCTTTAA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNFVSILMGSKSDYETMKEAAKTLESFGVKYELIISSAHRSPKRTKEYIANAEEKGVKVFIAAAGMAAHLAGAVAAYTTK
PVLGVPMSGSNLASMDSLFSTVQMPSGIPVGTLAIGKAGAINAAYLAMQILAIYDVDLAQKLKEDRLEKEKKLVSDSKEV
EVLL

Sequences:

>Translated_164_residues
MNFVSILMGSKSDYETMKEAAKTLESFGVKYELIISSAHRSPKRTKEYIANAEEKGVKVFIAAAGMAAHLAGAVAAYTTK
PVLGVPMSGSNLASMDSLFSTVQMPSGIPVGTLAIGKAGAINAAYLAMQILAIYDVDLAQKLKEDRLEKEKKLVSDSKEV
EVLL
>Mature_164_residues
MNFVSILMGSKSDYETMKEAAKTLESFGVKYELIISSAHRSPKRTKEYIANAEEKGVKVFIAAAGMAAHLAGAVAAYTTK
PVLGVPMSGSNLASMDSLFSTVQMPSGIPVGTLAIGKAGAINAAYLAMQILAIYDVDLAQKLKEDRLEKEKKLVSDSKEV
EVLL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=143, Percent_Identity=55.2447552447552, Blast_Score=120, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=161, Percent_Identity=44.7204968944099, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI18860083, Length=126, Percent_Identity=32.5396825396825, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17503; Mature: 17503

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVSILMGSKSDYETMKEAAKTLESFGVKYELIISSAHRSPKRTKEYIANAEEKGVKVF
CCHHEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEE
IAAAGMAAHLAGAVAAYTTKPVLGVPMSGSNLASMDSLFSTVQMPSGIPVGTLAIGKAGA
EEECCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCC
INAAYLAMQILAIYDVDLAQKLKEDRLEKEKKLVSDSKEVEVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MNFVSILMGSKSDYETMKEAAKTLESFGVKYELIISSAHRSPKRTKEYIANAEEKGVKVF
CCHHEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEE
IAAAGMAAHLAGAVAAYTTKPVLGVPMSGSNLASMDSLFSTVQMPSGIPVGTLAIGKAGA
EEECCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCC
INAAYLAMQILAIYDVDLAQKLKEDRLEKEKKLVSDSKEVEVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]