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The map label for this gene is pdhA [H]

Identifier: 55980908

GI number: 55980908

Start: 886814

End: 887854

Strand: Reverse

Name: pdhA [H]

Synonym: TTHA0939

Alternate gene names: 55980908

Gene position: 887854-886814 (Counterclockwise)

Preceding gene: 55980909

Following gene: 55980907

Centisome position: 48.0

GC content: 70.03

Gene sequence:

>1041_bases
GTGAAGCCGAAGGTGGTGCGGTATCTGGATGAAGGGGAGTTCCCCCTAGCGGAGGAAGAAGCCCTGAGGCTCTACCGGGC
CATGCGCCGGGCCCGGTTTTTTGACGAGAAGGCCCTCACCCTCCAGCGCCAGGGGAGGCTTGGGGTCTACGCCCCCTTCA
TGGGCCAGGAGGCGGCCCAGGTGGGGGTGGCCCTGGCCCTGGAGGAGAGGGACTGGGTCGTCCCCTCCTACCGGGAAAGC
GCCATGCTCCTCGCCAAGGGGCTTCCCATCCACACCCTCATCCTCTACTGGCGGGCCCACCCTGCCGGCTGGCGCTTCCC
CGAGGGGGTCAGGGCGGTGAACCCCTACATCCCCATCGCCACCCAGATCCCCCAGGCGGTGGGGCTCGCCCTGGCCGGGC
GGTACCGGGGGGAGGACTGGGTGGTGGCCACCTCCATCGGGGACGGGGGGACGAGCGAGGGGGACTTCCACGAGGGGCTG
AACTTCGCCGCGGTCTTCGGCGCCCCCGTGGTCTTCCTGGTGCAGAACAACGGCTACGCCATCAGCGTCCCCAAAAGCCG
CCAGATGAAGGTGGACTACGTGGCGAGGCGGGCCGAGGGGTACGGGATGCCGGGGGTGGTGGTGGACGGGAACGACGCCT
TCGCCGTGTACCTCGAGGCCAAGAAGGCGGTGGAGAGGGCCAGGAAGGGGGAGGGCCCCACCCTCCTCGAGGCCCTCACC
TACCGCCTCGCCCCCCACACCACCTCCGACGACCCCTCCCGCTACCGCAGCAAAGAGGAAGAGGAAGCCTGGCGGGCCAA
GGACCCGATCCTCCGCCTGCGGAAGGCCCTGGAGGGGCGGGGCCTCTGGGGCGAGGAGGCGGAGAAGGCGCTTCTTCTTG
AGCTTGAGGAGGAGTTCCAGAGGGAGCTCGCCCTGGCCGACGAAGCCCCCGAGCCCAGGCCCGAGGAGATCGTGGAGCAC
GTCTACGCCGAGATGGGCCCCGACCAGAGGCGGGCCTGGGAGGCCCTCAGGCGAGGCCTCCACGTGGAGGAGGTGGAGTG
A

Upstream 100 bases:

>100_bases
GAAGACCCTCCCAAGGACCTCTTCCGCTTCGCCTTCTGCAAGACTGAGGAGGAGCTTCACCTCGCCCTGGAGCGCCTGGG
GCGTGTGGTAAACTCCCCCC

Downstream 100 bases:

>100_bases
TGCGCGTCCTCAACATGGTCCAAGCCATCAACGAGGCCCTGGACCTGGCCCTTTCCCGGGACGAGCGGGTTTTGGTCTTC
GGGGAGGACGTGGGGCGGCT

Product: pyruvate dehydrogenase (lipoamide) E1-subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKPKVVRYLDEGEFPLAEEEALRLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALALEERDWVVPSYRES
AMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIATQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGL
NFAAVFGAPVVFLVQNNGYAISVPKSRQMKVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVERARKGEGPTLLEALT
YRLAPHTTSDDPSRYRSKEEEEAWRAKDPILRLRKALEGRGLWGEEAEKALLLELEEEFQRELALADEAPEPRPEEIVEH
VYAEMGPDQRRAWEALRRGLHVEEVE

Sequences:

>Translated_346_residues
MKPKVVRYLDEGEFPLAEEEALRLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALALEERDWVVPSYRES
AMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIATQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGL
NFAAVFGAPVVFLVQNNGYAISVPKSRQMKVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVERARKGEGPTLLEALT
YRLAPHTTSDDPSRYRSKEEEEAWRAKDPILRLRKALEGRGLWGEEAEKALLLELEEEFQRELALADEAPEPRPEEIVEH
VYAEMGPDQRRAWEALRRGLHVEEVE
>Mature_346_residues
MKPKVVRYLDEGEFPLAEEEALRLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALALEERDWVVPSYRES
AMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIATQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGL
NFAAVFGAPVVFLVQNNGYAISVPKSRQMKVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVERARKGEGPTLLEALT
YRLAPHTTSDDPSRYRSKEEEEAWRAKDPILRLRKALEGRGLWGEEAEKALLLELEEEFQRELALADEAPEPRPEEIVEH
VYAEMGPDQRRAWEALRRGLHVEEVE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=338, Percent_Identity=39.3491124260355, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI258645172, Length=338, Percent_Identity=39.3491124260355, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=31.25, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI4505685, Length=332, Percent_Identity=30.1204819277108, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI291084742, Length=327, Percent_Identity=30.5810397553517, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI291084744, Length=339, Percent_Identity=29.4985250737463, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI291084757, Length=319, Percent_Identity=27.8996865203762, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=340, Percent_Identity=36.7647058823529, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI86563355, Length=340, Percent_Identity=36.7647058823529, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI32564172, Length=335, Percent_Identity=30.1492537313433, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17536047, Length=335, Percent_Identity=30.1492537313433, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=30.1587301587302, Blast_Score=135, Evalue=9e-33,
Organism=Drosophila melanogaster, GI21355903, Length=333, Percent_Identity=36.9369369369369, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24639740, Length=337, Percent_Identity=27.299703264095, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639744, Length=337, Percent_Identity=27.299703264095, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571106, Length=337, Percent_Identity=27.299703264095, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639748, Length=344, Percent_Identity=28.1976744186047, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24639746, Length=282, Percent_Identity=27.3049645390071, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38943; Mature: 38943

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKVVRYLDEGEFPLAEEEALRLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQ
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
VGVALALEERDWVVPSYRESAMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIA
HCEEEEEECCCCCCCCHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCCCHHCCCCCCCH
TQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGLNFAAVFGAPVVFLVQNNGYA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCEEEECCCCEEEEEECCCEE
ISVPKSRQMKVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVERARKGEGPTLLEALT
EECCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEEEHHHHHHHHHCCCCCHHHHHHH
YRLAPHTTSDDPSRYRSKEEEEAWRAKDPILRLRKALEGRGLWGEEAEKALLLELEEEFQ
HHHCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RELALADEAPEPRPEEIVEHVYAEMGPDQRRAWEALRRGLHVEEVE
HHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKPKVVRYLDEGEFPLAEEEALRLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQ
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
VGVALALEERDWVVPSYRESAMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIA
HCEEEEEECCCCCCCCHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCCCCHHCCCCCCCH
TQIPQAVGLALAGRYRGEDWVVATSIGDGGTSEGDFHEGLNFAAVFGAPVVFLVQNNGYA
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHCCCEEEECCCCEEEEEECCCEE
ISVPKSRQMKVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVERARKGEGPTLLEALT
EECCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEEEEHHHHHHHHHCCCCCHHHHHHH
YRLAPHTTSDDPSRYRSKEEEEAWRAKDPILRLRKALEGRGLWGEEAEKALLLELEEEFQ
HHHCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
RELALADEAPEPRPEEIVEHVYAEMGPDQRRAWEALRRGLHVEEVE
HHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]