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The map label for this gene is pdhB [H]

Identifier: 55980907

GI number: 55980907

Start: 885834

End: 886814

Strand: Reverse

Name: pdhB [H]

Synonym: TTHA0938

Alternate gene names: 55980907

Gene position: 886814-885834 (Counterclockwise)

Preceding gene: 55980908

Following gene: 55980906

Centisome position: 47.94

GC content: 69.11

Gene sequence:

>981_bases
ATGCGCGTCCTCAACATGGTCCAAGCCATCAACGAGGCCCTGGACCTGGCCCTTTCCCGGGACGAGCGGGTTTTGGTCTT
CGGGGAGGACGTGGGGCGGCTCGGGGGGGTCTTCCGGGTCACGGAGGGCCTGCAGGCGAAGTACGGGGAGAAGCGGGTCT
TTGACACGCCCCTGGCGGAAAGCGGCATCCTGGGGATGGCCATCGGGCTCGCCATGGGGGGGATGCGTCCCGTGGCCGAG
ATCCAGTTTGCCGGGTTTTTGTATCCTGCCCTGGACCAGATCCTCTCCCACCTCGGCCGCTGGCGGCACCGCTCCCGGGG
ACGGGTGGGGCTTCCCGTGGTGGTGCGGGCCCCTTACGGCGGGGGCGTCCACACCCCGGAGCAGCACGCCGACTCCCCCG
AGGCCCTCCTCTGCCACACCCCGGGGGTCAAGGTGGTGATCCCCTCAAGCCCGGAAAGGGCCAAGGGGCTTCTCCTTTCC
GCCATTGAGGACGAGGACCCCGTGTTCTTCCTCGAGGCCATCAAGCTCTACCGGGGCGCGAGGGCGGAGGTGCCGGAAGG
GTACTACACCCTGCCCCTGGGGAAGGCCCGGGTCCTTAGGGAGGGAAAGGCGGCCACCTTAATCGGCTACGGGGGCATGG
TGGAGGTGATGCTGGAGGCGGCGGAGGTGGCCCAAAGGGAGGGGGTGGAGGTCACGGTGGTGGACCTGGAGACCCTGGTC
CCCCTGGACGAGGAGACCCTCCTCGAGGCCGTGCGGGCGACGGGCCGGGCCATCGTGGTCTACGAGGCCATGCGCACCGG
GGGCTTCGGGGCGGAGATCGCGGCCCGCATCGCCGAAGGGGCCATAGACTACCTCCAGGCCCCGGTTCTCCGGGTGGCGG
GCTACGACGCCCCTTACCCGCCCTTCAGCGCCATTGAGCACCTCTACCGGCCAAACGCGAGGAGGGTCCTCGCCGCCTTG
AGGAAGGCGCTAACCTACTAA

Upstream 100 bases:

>100_bases
CCGAGGAGATCGTGGAGCACGTCTACGCCGAGATGGGCCCCGACCAGAGGCGGGCCTGGGAGGCCCTCAGGCGAGGCCTC
CACGTGGAGGAGGTGGAGTG

Downstream 100 bases:

>100_bases
GGAGGAGGCCCCATGGTCAAGACCCGCCTGACGGCCGAGGAGTTCTTCGCCCTGCCTCTAGAGCGGGGGGAGCTTGTGGA
CGGGGAGGTCCGGGAGGAGA

Product: pyruvate dehydrogenase E1 component subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MRVLNMVQAINEALDLALSRDERVLVFGEDVGRLGGVFRVTEGLQAKYGEKRVFDTPLAESGILGMAIGLAMGGMRPVAE
IQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYGGGVHTPEQHADSPEALLCHTPGVKVVIPSSPERAKGLLLS
AIEDEDPVFFLEAIKLYRGARAEVPEGYYTLPLGKARVLREGKAATLIGYGGMVEVMLEAAEVAQREGVEVTVVDLETLV
PLDEETLLEAVRATGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYPPFSAIEHLYRPNARRVLAAL
RKALTY

Sequences:

>Translated_326_residues
MRVLNMVQAINEALDLALSRDERVLVFGEDVGRLGGVFRVTEGLQAKYGEKRVFDTPLAESGILGMAIGLAMGGMRPVAE
IQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYGGGVHTPEQHADSPEALLCHTPGVKVVIPSSPERAKGLLLS
AIEDEDPVFFLEAIKLYRGARAEVPEGYYTLPLGKARVLREGKAATLIGYGGMVEVMLEAAEVAQREGVEVTVVDLETLV
PLDEETLLEAVRATGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYPPFSAIEHLYRPNARRVLAAL
RKALTY
>Mature_326_residues
MRVLNMVQAINEALDLALSRDERVLVFGEDVGRLGGVFRVTEGLQAKYGEKRVFDTPLAESGILGMAIGLAMGGMRPVAE
IQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYGGGVHTPEQHADSPEALLCHTPGVKVVIPSSPERAKGLLLS
AIEDEDPVFFLEAIKLYRGARAEVPEGYYTLPLGKARVLREGKAATLIGYGGMVEVMLEAAEVAQREGVEVTVVDLETLV
PLDEETLLEAVRATGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYPPFSAIEHLYRPNARRVLAAL
RKALTY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=44.6153846153846, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=44.6153846153846, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI156564403, Length=323, Percent_Identity=38.390092879257, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI291084858, Length=323, Percent_Identity=37.1517027863777, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1786622, Length=224, Percent_Identity=29.9107142857143, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=44, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=38.2262996941896, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17539652, Length=280, Percent_Identity=26.7857142857143, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=330, Percent_Identity=35.4545454545455, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=45.5384615384615, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=45.5384615384615, Blast_Score=293, Evalue=8e-80,
Organism=Drosophila melanogaster, GI21358145, Length=327, Percent_Identity=39.1437308868502, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24650940, Length=327, Percent_Identity=39.1437308868502, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24650943, Length=92, Percent_Identity=44.5652173913043, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24650945, Length=92, Percent_Identity=44.5652173913043, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI160714826, Length=65, Percent_Identity=56.9230769230769, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35340; Mature: 35340

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00850 GLY_RADICAL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLNMVQAINEALDLALSRDERVLVFGEDVGRLGGVFRVTEGLQAKYGEKRVFDTPLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
SGILGMAIGLAMGGMRPVAEIQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPEQHADSPEALLCHTPGVKVVIPSSPERAKGLLLSAIEDEDPVFFLEAIKLYRGA
CCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCC
RAEVPEGYYTLPLGKARVLREGKAATLIGYGGMVEVMLEAAEVAQREGVEVTVVDLETLV
CCCCCCCEEECCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHC
PLDEETLLEAVRATGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYP
CCCHHHHHHHHHHCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PFSAIEHLYRPNARRVLAALRKALTY
CHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLNMVQAINEALDLALSRDERVLVFGEDVGRLGGVFRVTEGLQAKYGEKRVFDTPLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
SGILGMAIGLAMGGMRPVAEIQFAGFLYPALDQILSHLGRWRHRSRGRVGLPVVVRAPYG
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
GGVHTPEQHADSPEALLCHTPGVKVVIPSSPERAKGLLLSAIEDEDPVFFLEAIKLYRGA
CCCCCCHHHCCCCCEEEEECCCEEEEECCCCCHHHHHHHEECCCCCCCHHHHHHHHHCCC
RAEVPEGYYTLPLGKARVLREGKAATLIGYGGMVEVMLEAAEVAQREGVEVTVVDLETLV
CCCCCCCEEECCCCHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHC
PLDEETLLEAVRATGRAIVVYEAMRTGGFGAEIAARIAEGAIDYLQAPVLRVAGYDAPYP
CCCHHHHHHHHHHCCCEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PFSAIEHLYRPNARRVLAALRKALTY
CHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]