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The map label for this gene is ltaA [H]

Identifier: 55980849

GI number: 55980849

Start: 837937

End: 839109

Strand: Reverse

Name: ltaA [H]

Synonym: TTHA0880

Alternate gene names: 55980849

Gene position: 839109-837937 (Counterclockwise)

Preceding gene: 55980851

Following gene: 55980848

Centisome position: 45.36

GC content: 72.63

Gene sequence:

>1173_bases
GTGTTTCGCTTCCTCCCGTGGCGGCGGGAAGGGCTTTCCGCCCTTCTCCGCCTCGTCCTCGTGGTGGGCCTCCTGGAGGG
GGTGCGGAGCGGCTACTTCGCCGGGCTGCTCCCCTTTTACGCCCCGGAGCACCTGGGGCTGGGGCCCGCCGCCTTCACCC
TGGCCTTTACCCTGCACCAGCTCGCGGAAAACCTCTCCAAGGCCGCAGGGGGGCTCCTGGCGGAGCGGCTCGGCTACGGG
CTCACGGTGACCCTGGCCGCCGCCACGGGCCTCCTCGCCCTCCTCCTCACCCCAAGGGCGGACTCGGCCTGGATCCTTTG
GACCCTCGGGGCCCTATGGGGCCTCACCTTCTCCTCCCTCTACCCCGGCCTCATGACCCTGGCGAGCCGCATCGCCCGCC
CCGGGATGGACGCCCGGGCCCTGGCCTTCACCCTGAGCCTGGTGATGCCCTGGGTGGGGCTCGGCCTCGTGGGGGTGGGC
CAGGTGGCCCAAAGGCACCCCCTCCAGGCCCTCTACCTCCTCCTCGCCGCCCAAGGGCTCGCCCTCCTCGTGGCCTTAAG
CCTGGTGCGCTTCCGCATCCCCGTCCCGCCCCCCTCCAGGGAGCGCTACCCCCTTTACCGCCTCCTCCTCTTCGTGCCCG
CGGCCTTCGGCCAAACCTTCGCCCCGGGGCTCGTCTCCCTCTTCCTCCTGCGCTTCGCCAAGGAGGAGCTCGGCCTCGAG
CCCCTGGCCCTGGGGGGCCTCCTCGTCCTGGGGGGCGGGGCGGCCTTCCTCCTCCTCCCCTTCACGGGCCGCCTGGTGGA
CCGGAGGGGCTACCAGGCGGCCCTCGTCCTCGGGCTTTTCCTCCTCGCCCTGGTCATGGCCCGGCTCGGCACCGGGCCCC
ACCCCTACGAGCTTCCCGCCGCCGCCCTCCTTGGGGGCCTCGGGTTCAGCCTCTTCCTCCCCGGGTGGAACGGGCTTCTG
GCCAAAAACCTGCCCCAGGAGAACCGGGCCGCCATCTGGGGTAGCCTCATGACCGTGGAGGGGCTCGGCCTCGCCCTGGG
CCCGGTGGCGGGCGGGCTCTTGTGGGAGGCCTTCGGCCTCCGGGCGCCCTTTCTCGCGGGCTCGGGCATCTTCCTGGCCC
TTAGCCTCCTCTACCTCCTCCTCTTCCGCGTGCGCGGGCTCTGGAGGCGGTGA

Upstream 100 bases:

>100_bases
GGAAGGGTCTGGGCCAAGACCGCCTCCAGGGCGGAGGGCAGGTAGGCCTCCTCGTTCCGGGCGGGAATCACCACGCTGAC
GCGCACGGGTATACTCTAGC

Downstream 100 bases:

>100_bases
TGGTGGAGCTTTTCGGCGCCGTTCTCCTCCTCTTTGGCCTCTCCGACCTCCTCTTCCGCTTCCTGGGCTTAGGGGCCTAC
GCCCACGGAAGCCGGCGGGA

Product: multidrug resistance protein-like protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: Lipoteichoic acid protein A [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFRFLPWRREGLSALLRLVLVVGLLEGVRSGYFAGLLPFYAPEHLGLGPAAFTLAFTLHQLAENLSKAAGGLLAERLGYG
LTVTLAAATGLLALLLTPRADSAWILWTLGALWGLTFSSLYPGLMTLASRIARPGMDARALAFTLSLVMPWVGLGLVGVG
QVAQRHPLQALYLLLAAQGLALLVALSLVRFRIPVPPPSRERYPLYRLLLFVPAAFGQTFAPGLVSLFLLRFAKEELGLE
PLALGGLLVLGGGAAFLLLPFTGRLVDRRGYQAALVLGLFLLALVMARLGTGPHPYELPAAALLGGLGFSLFLPGWNGLL
AKNLPQENRAAIWGSLMTVEGLGLALGPVAGGLLWEAFGLRAPFLAGSGIFLALSLLYLLLFRVRGLWRR

Sequences:

>Translated_390_residues
MFRFLPWRREGLSALLRLVLVVGLLEGVRSGYFAGLLPFYAPEHLGLGPAAFTLAFTLHQLAENLSKAAGGLLAERLGYG
LTVTLAAATGLLALLLTPRADSAWILWTLGALWGLTFSSLYPGLMTLASRIARPGMDARALAFTLSLVMPWVGLGLVGVG
QVAQRHPLQALYLLLAAQGLALLVALSLVRFRIPVPPPSRERYPLYRLLLFVPAAFGQTFAPGLVSLFLLRFAKEELGLE
PLALGGLLVLGGGAAFLLLPFTGRLVDRRGYQAALVLGLFLLALVMARLGTGPHPYELPAAALLGGLGFSLFLPGWNGLL
AKNLPQENRAAIWGSLMTVEGLGLALGPVAGGLLWEAFGLRAPFLAGSGIFLALSLLYLLLFRVRGLWRR
>Mature_390_residues
MFRFLPWRREGLSALLRLVLVVGLLEGVRSGYFAGLLPFYAPEHLGLGPAAFTLAFTLHQLAENLSKAAGGLLAERLGYG
LTVTLAAATGLLALLLTPRADSAWILWTLGALWGLTFSSLYPGLMTLASRIARPGMDARALAFTLSLVMPWVGLGLVGVG
QVAQRHPLQALYLLLAAQGLALLVALSLVRFRIPVPPPSRERYPLYRLLLFVPAAFGQTFAPGLVSLFLLRFAKEELGLE
PLALGGLLVLGGGAAFLLLPFTGRLVDRRGYQAALVLGLFLLALVMARLGTGPHPYELPAAALLGGLGFSLFLPGWNGLL
AKNLPQENRAAIWGSLMTVEGLGLALGPVAGGLLWEAFGLRAPFLAGSGIFLALSLLYLLLFRVRGLWRR

Specific function: Probable permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. LtaA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41674; Mature: 41674

Theoretical pI: Translated: 11.25; Mature: 11.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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CCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA